Q44504 (DSBA_AZOVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbA

Gene names

Name:

dsbA

Organism

Azotobacter vinelandii

Taxonomic identifier

354 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Azotobacter

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 214	197	Thiol:disulfide interchange protein DsbA		PRO_0000034247
Regions
	Domain	18 – 208	191	Thioredoxin
Amino acid modifications
	Disulfide bond	61 ↔ 64		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q44504 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 47DC6A43478B0EE7	FASTA	214	23,446
	10 20 30 40 50 60 MRKLILGAIL AGTSLFALGT QAESLSPADI KIGRQYVELP THVPVAQPGK IEVVELFWYG 70 80 90 100 110 120 CPHCYQFEPS INAWAGKLPE DVSFRRVPAL FGGLWNIHGQ LFLTLEAMGV EPKVHTAIFD 130 140 150 160 170 180 AIHKDGKKLA TPEEMAEFLA GHGIDKDAFL KAYGSFNVKS QMEKAKKLAI AYQISGVPVM 190 200 210 VVNGKYRFDL GSAGGPENTL QVADYLIEQE RSAQ

References

[1]	"Cloning and expression of the gene for a protein disulfide oxidoreductase from Azotobacter vinelandii: complementation of an Escherichia coli dsbA mutant strain." Ng T.C.N., Kwik J.F., Maier R.J. Gene 188:109-113(1997) [PubMed: 9099867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CA.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L76098 Genomic DNA. Translation: AAB53016.1.
3D structure databases
ProteinModelPortal	Q44504.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001853. DSBA-like_thioredoxin_dom. IPR023205. Thiol:disulphide_interchange. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PIRSF	PIRSF001488. Tdi_protein. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_AZOVI

Accession

Primary (citable) accession number: Q44504

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program