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Q44407

- PGMI_CALBD

UniProt

Q44407 - PGMI_CALBD

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Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

Athe_0619

Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei221 – 2211Proton acceptorBy similarity
Active sitei237 – 2371Proton donorBy similarity
Active sitei331 – 3311Proton acceptorBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
  3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciCBES521460:GH8H-630-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:Athe_0619
OrganismiCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Taxonomic identifieri521460 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000007723: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227792Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi521460.Athe_0619.

Structurei

3D structure databases

ProteinModelPortaliQ44407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 164143SISPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PGI/PMI family.Curated
Contains 1 SIS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000020037.
KOiK15916.
OrthoDBiEOG6RC3QN.

Family and domain databases

InterProiIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamiPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q44407-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFESVYNLPE QIQKAYEIGK NISVNVKAED IDKVVITGLG GSAIGGNLLR
60 70 80 90 100
VFVLDKCKIP VIVNRDYVLP AYVDSKTLVI ASSYSGNTEE TLSAYQDAKA
110 120 130 140 150
KGAKIIAITT GGKLKEFAEK DGFDVITIPS GLQPRAALGY SFIPLLMLFV
160 170 180 190 200
KLGLIEPVDD QIEETVKVLS DLRERYKPEV PEEKNLAKRL TLKLWNKLPI
210 220 230 240 250
IYGISGTTEV IAERWKGQIC ENSKSPAYFN VFSELNHNEI VGTESPKHIL
260 270 280 290 300
GLFEIVMLHD TEDHKRNAIR MDITKDLIKG VVSGVNDIYS IGNSRLARMF
310 320 330
SLIYLGDYVS LYLATLYQND PTPVKKIDIL KNKLAEIKD
Length:339
Mass (Da):37,787
Last modified:March 21, 2006 - v2
Checksum:i7C5EE355D649B091
GO

Sequence cautioni

The sequence ACM59743.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA93628.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69782 Genomic DNA. Translation: CAA93628.1. Different initiation.
CP001393 Genomic DNA. Translation: ACM59743.1. Different initiation.
RefSeqiYP_002572516.1. NC_012034.1.

Genome annotation databases

EnsemblBacteriaiACM59743; ACM59743; Athe_0619.
GeneIDi7406960.
KEGGiate:Athe_0619.
PATRICi20898264. VBIAnaThe135187_0655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69782 Genomic DNA. Translation: CAA93628.1 . Different initiation.
CP001393 Genomic DNA. Translation: ACM59743.1 . Different initiation.
RefSeqi YP_002572516.1. NC_012034.1.

3D structure databases

ProteinModelPortali Q44407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521460.Athe_0619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM59743 ; ACM59743 ; Athe_0619 .
GeneIDi 7406960.
KEGGi ate:Athe_0619.
PATRICi 20898264. VBIAnaThe135187_0655.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000020037.
KOi K15916.
OrthoDBi EOG6RC3QN.

Enzyme and pathway databases

BioCyci CBES521460:GH8H-630-MONOMER.

Family and domain databases

InterProi IPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view ]
Pfami PF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Zverlov V.V., Bronnenmeier K., Velikodvorskaya G.A.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

Entry informationi

Entry nameiPGMI_CALBD
AccessioniPrimary (citable) accession number: Q44407
Secondary accession number(s): B9MPI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: October 1, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3