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Q44407

- PGMI_CALBD

UniProt

Q44407 - PGMI_CALBD

Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

Athe_0619

Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (21 Mar 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.
    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei221 – 2211Proton acceptorBy similarity
    Active sitei237 – 2371Proton donorBy similarity
    Active sitei331 – 3311Proton acceptorBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
    3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciCBES521460:GH8H-630-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional phosphoglucose/phosphomannose isomerase
    Alternative name(s):
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Ordered Locus Names:Athe_0619
    OrganismiCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
    Taxonomic identifieri521460 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000007723: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227792Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi521460.Athe_0619.

    Structurei

    3D structure databases

    ProteinModelPortaliQ44407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 164143SISPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PGI/PMI family.Curated
    Contains 1 SIS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000020037.
    KOiK15916.
    OrthoDBiEOG6RC3QN.

    Family and domain databases

    InterProiIPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF10432. bact-PGI_C. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q44407-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFESVYNLPE QIQKAYEIGK NISVNVKAED IDKVVITGLG GSAIGGNLLR    50
    VFVLDKCKIP VIVNRDYVLP AYVDSKTLVI ASSYSGNTEE TLSAYQDAKA 100
    KGAKIIAITT GGKLKEFAEK DGFDVITIPS GLQPRAALGY SFIPLLMLFV 150
    KLGLIEPVDD QIEETVKVLS DLRERYKPEV PEEKNLAKRL TLKLWNKLPI 200
    IYGISGTTEV IAERWKGQIC ENSKSPAYFN VFSELNHNEI VGTESPKHIL 250
    GLFEIVMLHD TEDHKRNAIR MDITKDLIKG VVSGVNDIYS IGNSRLARMF 300
    SLIYLGDYVS LYLATLYQND PTPVKKIDIL KNKLAEIKD 339
    Length:339
    Mass (Da):37,787
    Last modified:March 21, 2006 - v2
    Checksum:i7C5EE355D649B091
    GO

    Sequence cautioni

    The sequence ACM59743.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA93628.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69782 Genomic DNA. Translation: CAA93628.1. Different initiation.
    CP001393 Genomic DNA. Translation: ACM59743.1. Different initiation.
    RefSeqiYP_002572516.1. NC_012034.1.

    Genome annotation databases

    EnsemblBacteriaiACM59743; ACM59743; Athe_0619.
    GeneIDi7406960.
    KEGGiate:Athe_0619.
    PATRICi20898264. VBIAnaThe135187_0655.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69782 Genomic DNA. Translation: CAA93628.1 . Different initiation.
    CP001393 Genomic DNA. Translation: ACM59743.1 . Different initiation.
    RefSeqi YP_002572516.1. NC_012034.1.

    3D structure databases

    ProteinModelPortali Q44407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 521460.Athe_0619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM59743 ; ACM59743 ; Athe_0619 .
    GeneIDi 7406960.
    KEGGi ate:Athe_0619.
    PATRICi 20898264. VBIAnaThe135187_0655.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000020037.
    KOi K15916.
    OrthoDBi EOG6RC3QN.

    Enzyme and pathway databases

    BioCyci CBES521460:GH8H-630-MONOMER.

    Family and domain databases

    InterProi IPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF10432. bact-PGI_C. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Zverlov V.V., Bronnenmeier K., Velikodvorskaya G.A.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

    Entry informationi

    Entry nameiPGMI_CALBD
    AccessioniPrimary (citable) accession number: Q44407
    Secondary accession number(s): B9MPI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3