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Q44407 (PGMI_CALBD) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Mannose-6-phosphate isomerase
EC=5.3.1.8
Phosphoglucose isomerase
Short name=PGI
Phosphomannose isomerase
Short name=PMI
Gene names
Ordered Locus Names:Athe_0619
OrganismCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum) [Complete proteome] [HAMAP]
Taxonomic identifier521460 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate.

D-mannose 6-phosphate = D-fructose 6-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the PGI/PMI family.

Contains 1 SIS domain.

Sequence caution

The sequence ACM59743.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA93628.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Bifunctional phosphoglucose/phosphomannose isomerase
PRO_0000227792

Regions

Domain22 – 164143SIS

Sites

Active site2211Proton acceptor By similarity
Active site2371Proton donor By similarity
Active site3311Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q44407 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: 7C5EE355D649B091

FASTA33937,787
        10         20         30         40         50         60 
MFESVYNLPE QIQKAYEIGK NISVNVKAED IDKVVITGLG GSAIGGNLLR VFVLDKCKIP 

        70         80         90        100        110        120 
VIVNRDYVLP AYVDSKTLVI ASSYSGNTEE TLSAYQDAKA KGAKIIAITT GGKLKEFAEK 

       130        140        150        160        170        180 
DGFDVITIPS GLQPRAALGY SFIPLLMLFV KLGLIEPVDD QIEETVKVLS DLRERYKPEV 

       190        200        210        220        230        240 
PEEKNLAKRL TLKLWNKLPI IYGISGTTEV IAERWKGQIC ENSKSPAYFN VFSELNHNEI 

       250        260        270        280        290        300 
VGTESPKHIL GLFEIVMLHD TEDHKRNAIR MDITKDLIKG VVSGVNDIYS IGNSRLARMF 

       310        320        330 
SLIYLGDYVS LYLATLYQND PTPVKKIDIL KNKLAEIKD 

« Hide

References

« Hide 'large scale' references
[1]Zverlov V.V., Bronnenmeier K., Velikodvorskaya G.A.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z69782 Genomic DNA. Translation: CAA93628.1. Different initiation.
CP001393 Genomic DNA. Translation: ACM59743.1. Different initiation.
RefSeqYP_002572516.1. NC_012034.1.

3D structure databases

ProteinModelPortalQ44407.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521460.Athe_0619.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM59743; ACM59743; Athe_0619.
GeneID7406960.
KEGGate:Athe_0619.
PATRIC20898264. VBIAnaThe135187_0655.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000020037.
KOK15916.
OrthoDBEOG6RC3QN.
ProtClustDBPRK08674.

Enzyme and pathway databases

BioCycCBES521460:GH8H-630-MONOMER.

Family and domain databases

InterProIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsTIGR02128. G6PI_arch. 1 hit.
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGMI_CALBD
AccessionPrimary (citable) accession number: Q44407
Secondary accession number(s): B9MPI2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: November 13, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families