Q44407 (PGMI_CALBD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase

Alternative name(s):
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Mannose-6-phosphate isomerase
EC=5.3.1.8
Phosphoglucose isomerase
Short name=PGI
Phosphomannose isomerase
Short name=PMI

Gene names

Ordered Locus Names:

Athe_0619

Organism

Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum) [Complete proteome] [HAMAP]

Taxonomic identifier

521460 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor › Caldicellulosiruptor bescii

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.
Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. D-mannose 6-phosphate = D-fructose 6-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the PGI/PMI family. Contains 1 SIS domain.
Sequence caution	The sequence ACM59743.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA93628.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Bifunctional phosphoglucose/phosphomannose isomerase		PRO_0000227792
Regions
	Domain	22 – 164	143	SIS
Sites
	Active site	221	1	Proton acceptor By similarity
	Active site	237	1	Proton donor By similarity
	Active site	331	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q44407 [UniParc]. Last modified March 21, 2006. Version 2. Checksum: 7C5EE355D649B091	FASTA	339	37,787
	10 20 30 40 50 60 MFESVYNLPE QIQKAYEIGK NISVNVKAED IDKVVITGLG GSAIGGNLLR VFVLDKCKIP 70 80 90 100 110 120 VIVNRDYVLP AYVDSKTLVI ASSYSGNTEE TLSAYQDAKA KGAKIIAITT GGKLKEFAEK 130 140 150 160 170 180 DGFDVITIPS GLQPRAALGY SFIPLLMLFV KLGLIEPVDD QIEETVKVLS DLRERYKPEV 190 200 210 220 230 240 PEEKNLAKRL TLKLWNKLPI IYGISGTTEV IAERWKGQIC ENSKSPAYFN VFSELNHNEI 250 260 270 280 290 300 VGTESPKHIL GLFEIVMLHD TEDHKRNAIR MDITKDLIKG VVSGVNDIYS IGNSRLARMF 310 320 330 SLIYLGDYVS LYLATLYQND PTPVKKIDIL KNKLAEIKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Zverlov V.V., Bronnenmeier K., Velikodvorskaya G.A. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z69782 Genomic DNA. Translation: CAA93628.1. Different initiation. CP001393 Genomic DNA. Translation: ACM59743.1. Different initiation.
RefSeq	YP_002572516.1. NC_012034.1.
3D structure databases
ProteinModelPortal	Q44407.
ModBase	Search...
Protein-protein interaction databases
STRING	521460.Athe_0619.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACM59743; ACM59743; Athe_0619.
GeneID	7406960.
KEGG	ate:Athe_0619.
PATRIC	20898264. VBIAnaThe135187_0655.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HOG000020037.
KO	K15916.
OMA	PELNHNE.
ProtClustDB	PRK08674.
Enzyme and pathway databases
BioCyc	CBES521460:GH8H-642-MONOMER.
Family and domain databases
InterPro	IPR011857. Glu6P/Mann6P_isomerase. IPR019490. Glu6P/Mann6P_isomerase_C. IPR001347. SIS. [Graphical view]
Pfam	PF10432. bact-PGI_C. 1 hit. PF01380. SIS. 1 hit. [Graphical view]
TIGRFAMs	TIGR02128. G6PI_arch. 1 hit.
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGMI_CALBD

Accession

Primary (citable) accession number: Q44407
Secondary accession number(s): B9MPI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program