Reviewed, UniProtKB/Swiss-Prot Q44407 (PGMI_ANATD)

Names and origin

Protein names

Recommended name:
    Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
    Phosphoglucose isomerase
      Short name=PGI
    Mannose-6-phosphate isomerase
    EC=5.3.1.8
    Phosphomannose isomerase
      Short name=PMI

Gene names

Ordered Locus Names:

Athe_0619

Organism

Anaerocellum thermophilum (strain DSM 6725 / Z-1320) [Complete proteome] [HAMAP]

Taxonomic identifier

521460 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Anaerocellum group › Anaerocellum

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.
Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. D-mannose 6-phosphate = D-fructose 6-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the PGI/PMI family. Contains 1 SIS domain.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC sugar binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Bifunctional phosphoglucose/phosphomannose isomerase		PRO_0000227792
Regions
	Domain	22 – 164	143	SIS
Sites
	Active site	221	1	Proton acceptor By similarity
	Active site	237	1	Proton donor By similarity
	Active site	331	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q44407-1 [UniParc]. Last modified March 21, 2006. Version 2. Checksum: 7C5EE355D649B091	FASTA	339	37,787
	10 20 30 40 50 60 MFESVYNLPE QIQKAYEIGK NISVNVKAED IDKVVITGLG GSAIGGNLLR VFVLDKCKIP 70 80 90 100 110 120 VIVNRDYVLP AYVDSKTLVI ASSYSGNTEE TLSAYQDAKA KGAKIIAITT GGKLKEFAEK 130 140 150 160 170 180 DGFDVITIPS GLQPRAALGY SFIPLLMLFV KLGLIEPVDD QIEETVKVLS DLRERYKPEV 190 200 210 220 230 240 PEEKNLAKRL TLKLWNKLPI IYGISGTTEV IAERWKGQIC ENSKSPAYFN VFSELNHNEI 250 260 270 280 290 300 VGTESPKHIL GLFEIVMLHD TEDHKRNAIR MDITKDLIKG VVSGVNDIYS IGNSRLARMF 310 320 330 SLIYLGDYVS LYLATLYQND PTPVKKIDIL KNKLAEIKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Zverlov V.V., Bronnenmeier K., Velikodvorskaya G.A. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z69782 Genomic DNA. Translation: CAA93628.1. Different initiation. CP001393 Genomic DNA. Translation: ACM59743.1. Different initiation.
RefSeq	YP_002572516.1.
3D structure databases
SMR	Q44407. Positions 1-334.
ModBase	Search...
Genome annotation databases
GeneID	7406960.
GenomeReviews	Gene locus Athe_0619 in contig CP001393_GR.
KEGG	ate:Athe_0619.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GNTEETL.
Enzyme and pathway databases
BRENDA	5.3.1.8. 97802. 5.3.1.9. 97802.
Family and domain databases
InterPro	IPR011857. Glu6P/Mann6P_isomerase. IPR019490. Glu6P/Mann6P_isomerase_C. IPR001347. SIS. [Graphical view]
Pfam	PF10432. bact-PGI_C. 1 hit. PF01380. SIS. 1 hit. [Graphical view]
TIGRFAMs	TIGR02128. G6PI_arch. 1 hit.
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGMI_ANATD

Accession

Primary (citable) accession number: Q44407
Secondary accession number(s): B9MPI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	February 9, 2010
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)