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Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

Athe_0619

Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Proton acceptorBy similarity1
Active sitei237Proton donorBy similarity1
Active sitei331Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:Athe_0619
OrganismiCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Taxonomic identifieri521460 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
Proteomesi
  • UP000007723 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277921 – 339Bifunctional phosphoglucose/phosphomannose isomeraseAdd BLAST339

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi521460.Athe_0619.

Structurei

3D structure databases

ProteinModelPortaliQ44407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 164SISPROSITE-ProRule annotationAdd BLAST143

Sequence similaritiesi

Belongs to the PGI/PMI family.Curated

Phylogenomic databases

eggNOGiENOG41086CI. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000020037.
KOiK15916.
OrthoDBiPOG091H052Y.

Family and domain databases

CDDicd05017. SIS_PGI_PMI_1. 1 hit.
cd05637. SIS_PGI_PMI_2. 1 hit.
InterProiView protein in InterPro
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR011857. PGI/PMI.
IPR001347. SIS.
IPR035484. SIS_PGI/PMI_1.
PfamiView protein in Pfam
PF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
PROSITEiView protein in PROSITE
PS51464. SIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q44407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFESVYNLPE QIQKAYEIGK NISVNVKAED IDKVVITGLG GSAIGGNLLR
60 70 80 90 100
VFVLDKCKIP VIVNRDYVLP AYVDSKTLVI ASSYSGNTEE TLSAYQDAKA
110 120 130 140 150
KGAKIIAITT GGKLKEFAEK DGFDVITIPS GLQPRAALGY SFIPLLMLFV
160 170 180 190 200
KLGLIEPVDD QIEETVKVLS DLRERYKPEV PEEKNLAKRL TLKLWNKLPI
210 220 230 240 250
IYGISGTTEV IAERWKGQIC ENSKSPAYFN VFSELNHNEI VGTESPKHIL
260 270 280 290 300
GLFEIVMLHD TEDHKRNAIR MDITKDLIKG VVSGVNDIYS IGNSRLARMF
310 320 330
SLIYLGDYVS LYLATLYQND PTPVKKIDIL KNKLAEIKD
Length:339
Mass (Da):37,787
Last modified:March 21, 2006 - v2
Checksum:i7C5EE355D649B091
GO

Sequence cautioni

Q44407: The sequence ACM59743 differs from that shown. Reason: Erroneous initiation.Curated
Q44407: The sequence CAA93628 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69782 Genomic DNA. Translation: CAA93628.1. Different initiation.
CP001393 Genomic DNA. Translation: ACM59743.1. Different initiation.
RefSeqiWP_015907196.1. NC_012034.1.

Genome annotation databases

EnsemblBacteriaiACM59743; ACM59743; Athe_0619.
GeneIDi31771974.
KEGGiate:Athe_0619.

Similar proteinsi

Entry informationi

Entry nameiPGMI_CALBD
AccessioniPrimary (citable) accession number: Q44407
Secondary accession number(s): B9MPI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: October 25, 2017
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families