Reviewed,
UniProtKB/Swiss-Prot Q44407 (PGMI_ANATD)
Last modified
February 9, 2010.
Version 43.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Bifunctional phosphoglucose/phosphomannose isomerase Alternative name(s): Glucose-6-phosphate isomerase Short name=GPI EC=5.3.1.9 Phosphoglucose isomerase Short name=PGI Mannose-6-phosphate isomerase EC=5.3.1.8 Phosphomannose isomerase Short name=PMI | ||
| Gene names |
| ||
| Organism | Anaerocellum thermophilum (strain DSM 6725 / Z-1320) [Complete proteome] [HAMAP] | ||
| Taxonomic identifier | 521460 [NCBI] | ||
| Taxonomic lineage | Bacteria › Firmicutes › Clostridia › Clostridiales › Anaerocellum group › Anaerocellum |
Protein attributes
| Sequence length | 339 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity. |
| Catalytic activity | D-glucose 6-phosphate = D-fructose 6-phosphate. D-mannose 6-phosphate = D-fructose 6-phosphate. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the PGI/PMI family. Contains 1 SIS domain. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Isomerase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC mannose-6-phosphate isomerase activityInferred from electronic annotation. Source: EC sugar bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 339 | 339 | Bifunctional phosphoglucose/phosphomannose isomerase | PRO_0000227792 | |||||
Regions | |||||||||
| Domain | 22 – 164 | 143 | SIS | ||||||
Sites | |||||||||
| Active site | 221 | 1 | Proton acceptor By similarity | ||||||
| Active site | 237 | 1 | Proton donor By similarity | ||||||
| Active site | 331 | 1 | Proton acceptor By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Zverlov V.V., Bronnenmeier K., Velikodvorskaya G.A. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z69782 Genomic DNA. Translation: CAA93628.1. Different initiation. CP001393 Genomic DNA. Translation: ACM59743.1. Different initiation. |
| RefSeq | YP_002572516.1. |
3D structure databases | |
| SMR | Q44407. Positions 1-334. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 7406960. |
| GenomeReviews | Gene locus Athe_0619 in contig CP001393_GR. |
| KEGG | ate:Athe_0619. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | GNTEETL. |
Enzyme and pathway databases | |
| BRENDA | 5.3.1.8. 97802. 5.3.1.9. 97802. |
Family and domain databases | |
| InterPro | IPR011857. Glu6P/Mann6P_isomerase. IPR019490. Glu6P/Mann6P_isomerase_C. IPR001347. SIS. [Graphical view] |
| Pfam | PF10432. bact-PGI_C. 1 hit. PF01380. SIS. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02128. G6PI_arch. 1 hit. |
| PROSITE | PS51464. SIS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PGMI_ANATD | ||||||||
| Accession | Primary (citable) accession number: Q44407 Secondary accession number(s): B9MPI2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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