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Q44244

- Q44244_9PSEU

UniProt

Q44244 - Q44244_9PSEU

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Protein
Submitted name:

N-acylamino acid racemase

Gene
Aaar
Organism
Amycolatopsis sp.
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi189 – 1891MagnesiumImported
Metal bindingi191 – 1911Magnesium
Metal bindingi214 – 2141MagnesiumImported
Metal bindingi239 – 2391MagnesiumImported

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

MagnesiumImported, Metal-bindingSAAS annotationsImported

Names & Taxonomyi

Protein namesi
Submitted name:
N-acylamino acid racemaseImported
Gene namesi
Name:AaarImported
OrganismiAmycolatopsis sp.Imported
Taxonomic identifieri37632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SJAX-ray2.30A/B/C/D1-368[»]
1SJBX-ray2.20A/B/C/D1-368[»]
1SJCX-ray2.10A/B/C/D1-368[»]
1SJDX-ray1.87A/B/C/D1-368[»]
4A6GX-ray2.71A/B/C/D1-368[»]
ProteinModelPortaliQ44244.
SMRiQ44244. Positions 1-368.

Miscellaneous databases

EvolutionaryTraceiQ44244.

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
IPR010197. OSB_synthase_lowGC-bac-typ.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PTHR13794:SF8. PTHR13794:SF8. 1 hit.
PfamiPF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01928. menC_lowGC/arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q44244-1 [UniParc]FASTAAdd to Basket

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MKLSGVELRR VQMPLVAPFR TSFGTQSVRE LLLLRAVTPA GEGWGECVTM    50
AGPLYSSEYN DGAEHVLRHY LIPALLAAED ITAAKVTPLL AKFKGHRMAK 100
GALEMAVLDA ELRAHERSFA AELGSVRDSV PCGVSVGIMD TIPQLLDVVG 150
GYLDEGYVRI KLKIEPGWDV EPVRAVRERF GDDVLLQVDA NTAYTLGDAP 200
QLARLDPFGL LLIEQPLEEE DVLGHAELAR RIQTPICLDE SIVSARAAAD 250
AIKLGAVQIV NIKPGRVGGY LEARRVHDVC AAHGIPVWCG GMIETGLGRA 300
ANVALASLPN FTLPGDTSAS DRFYKTDITE PFVLSGGHLP VPTGPGLGVA 350
PIPELLDEVT TAKVWIGS 368
Length:368
Mass (Da):39,406
Last modified:November 1, 1996 - v1
Checksum:i623A27548DA0E8C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30738 Genomic DNA. Translation: BAA06400.1.
PIRiI39598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30738 Genomic DNA. Translation: BAA06400.1 .
PIRi I39598.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SJA X-ray 2.30 A/B/C/D 1-368 [» ]
1SJB X-ray 2.20 A/B/C/D 1-368 [» ]
1SJC X-ray 2.10 A/B/C/D 1-368 [» ]
1SJD X-ray 1.87 A/B/C/D 1-368 [» ]
4A6G X-ray 2.71 A/B/C/D 1-368 [» ]
ProteinModelPortali Q44244.
SMRi Q44244. Positions 1-368.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q44244.

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProi IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
IPR010197. OSB_synthase_lowGC-bac-typ.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
PTHR13794:SF8. PTHR13794:SF8. 1 hit.
Pfami PF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsi TIGR01928. menC_lowGC/arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning, DNA sequencing and heterologous expression of the gene for thermostable N-acylamino acid racemase from Amycolatopsis sp. TS-1-60 in Escherichia coli."
    Tokuyama S., Hatano K.
    Appl. Microbiol. Biotechnol. 42:884-889(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TS-1-60Imported.
  2. "Evolution of enzymatic activity in the enolase superfamily: structural studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis."
    Thoden J.B., Taylor Ringia E.A., Garrett J.B., Gerlt J.A., Holden H.M., Rayment I.
    Biochemistry 43:5716-5727(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  3. "An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids."
    Baxter S., Royer S., Grogan G., Brown F., Holt-Tiffin K.E., Taylor I.N., Fotheringham I.G., Campopiano D.J.
    J. Am. Chem. Soc. 134:19310-19313(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Entry informationi

Entry nameiQ44244_9PSEU
AccessioniPrimary (citable) accession number: Q44244
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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