Reviewed, UniProtKB/Swiss-Prot Q44151 (DHAS_ACTPL)

Names and origin

Protein names

Recommended name:
    Aspartate-semialdehyde dehydrogenase
      Short name=ASA dehydrogenase
      Short name=ASADH
    EC=1.2.1.11

Gene names

Name:

asd

Organism

Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)

Taxonomic identifier

715 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	286 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 2/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the aspartate-semialdehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro NADP or NADPH binding Inferred from electronic annotation. Source: InterPro aspartate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›286	›286	Aspartate-semialdehyde dehydrogenase		PRO_0000141358
Sites
	Active site	136	1	Acyl-thioester intermediate By similarity
Experimental info
	Non-terminal residue	286	1

Sequences

	Sequence		Length	Mass (Da)
	Q44151-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: FA5881D57000279F	FASTA	286	31,167
	10 20 30 40 50 60 MQNVGFIGWR GMVGSVLMDR MVQENDFANI NPIFFTTSQA GQKAPVFAGK DAGELKNAFD 70 80 90 100 110 120 IEELKKLDII VTCQGGDYTN EVYPKLKATG WNGYWIDAAS ALRMEKDAII VLDPVNQHVI 130 140 150 160 170 180 SEGLKNGIKT FVGGNCTVSL MLMAIGGLFE KDLVEWVSVA TYQAASGAGA KNMRELLSQM 190 200 210 220 230 240 GELEASVKAE LANPASSILE IERKVTAKMR EDSFPTDNFG APLAGSLIPW IDKLLESGQT 250 260 270 280 KEEWKGYAET NKILGLSDNP IPVDGLCVRI GALRCHSQAF TIKLKK

References

[1]	Helie M.C., Sirois M., Ouellet C., Boissinot M. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S 4074 / Serotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U51440 Genomic DNA. Translation: AAB02815.1.
3D structure databases
HSSP	HSSP built from PDB template 1BRM based on UniProtKB P00353.
SMR	Q44151. Positions 1-286.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.11. 257522.
Family and domain databases
InterPro	IPR000319. Asp-semialdehyde_DH_CS. IPR011534. Asp_ADH_proteob. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01745. asd_gamma. 1 hit.
PROSITE	PS01103. ASD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHAS_ACTPL

Accession

Primary (citable) accession number: Q44151

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)