Q44131 (Q44131_ACTPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: 3-amino-5-hydroxybenzoic acid synthase EMBL AAC13997.1
Organism	Actinosynnema pretiosum subsp. auranticum EMBL AAC13997.1
Taxonomic identifier	42198 [NCBI]
Taxonomic lineage	Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Actinosynnemataceae › Actinosynnema

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the degT/dnrJ/eryC1 family. RuleBase RU004508

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU004509
Gene Ontology (GO)
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q44131 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 44EFCC09E2CB3D8B	FASTA	388	41,983
	10 20 30 40 50 60 MGSSPDAGID FPAWPQHDDA ERAALLRALD QGQWWRVGGS EVDEFEREFA EYHGAGHALA 70 80 90 100 110 120 VTNGTHALEL ALQVLDVGPG TEVIVPAFTF ISSSQAVQRL GAVAVPVDVD PDTYCLDVAA 130 140 150 160 170 180 AEDAVTSRTS AIMPVHMAGQ FADMDRLDKL SASTGVPVVQ DAAHAHGAHW RGKRVGELGS 190 200 210 220 230 240 IATFSFQNGK LMTAGEGGAV LFADQAQWEK AFVLHSCGRP KGDRGYFHLT SGSNFRMNEF 250 260 270 280 290 300 SAAVLRAQLG RLDSQIATRQ ARWPVLSALL AGIDGVVPQT VDPRSDRNPS YMAMFRMPGV 310 320 330 340 350 360 TEERRNAVVD ELVRRGIPAF MAFRAVYRTQ AFWETGAPDL TPEELAARCP VSEEITRDCV 370 380 WLHHRVLLGA EEQVRRLAAV VADVVAGA

References

[1]	"Formation of 3-amino-5-hydroxy-benzoic acid, the precursor of mC7N units in ansamycin antibiotics, by a new variant of the shikimate pathway." Kim C.G., Kirschning A., Bergon P., Ahn Y., Wang J.J., Shibuya M., Floss H.G. J. Am. Chem. Soc. 114:4941-4943(1992) Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC31565 EMBL AAC13997.1.
[2]	"Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699." August P.R., Tang L., Yoon Y.J., Ning S., Muller R., Yu T.W., Taylor M., Hoffmann D., Kim C.G., Zhang X., Hutchinson C.R., Floss H.G. Chem. Biol. 5:69-79(1998) [PubMed: 9512878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC31565 EMBL AAC13997.1.
[3]	"3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics." Kim C.G., Yu T.W., Fryhle C.B., Handa S., Floss H.G. J. Biol. Chem. 273:6030-6040(1998) [PubMed: 9497318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC31565 EMBL AAC13997.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33059 Genomic DNA. Translation: AAC13997.1.
PIR	I39657.
3D structure databases
HSSP	HSSP built from PDB template 1B9H based on UniProtKB O52552.
ProteinModelPortal	Q44131.
SMR	Q44131. Positions 10-388.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000653. DegT/StrS_aminotransferase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF01041. DegT_DnrJ_EryC1. 1 hit. [Graphical view]
PIRSF	PIRSF000390. PLP_StrS. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q44131_ACTPA

Accession

Primary (citable) accession number: Q44131

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	March 8, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)