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Q44104 (PHEA_AMYME) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Prephenate dehydratase

Short name=PDT
EC=4.2.1.51
Gene names
Name:pheA
Synonyms:pdt
OrganismAmycolatopsis methanolica
Taxonomic identifier1814 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Prephenate = phenylpyruvate + H2O + CO2.

Pathway

Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate dehydratase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Prephenate dehydratase
PRO_0000119175

Regions

Domain3 – 178176Prephenate dehydratase
Domain192 – 26978ACT

Sites

Site1711Essential for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q44104 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E19052658CC9E52F

FASTA30432,321
        10         20         30         40         50         60 
MSRIAYFGPV GTFTEQAART FMAAGDELVA AETIPKALDA VRRGEADAAC VPVENSVEGA 

        70         80         90        100        110        120 
VPATLDSLAV GEPLIGVAEA LLPVHFSVLT RDDVGEIRTV ASHPHALAQV RKWLEDNLPG 

       130        140        150        160        170        180 
ARVVAAGSTA AAAVAVQAGE FDAAVTAPVA VEHYPLKVLA TEVADVRDAR TRFLLMRRPP 

       190        200        210        220        230        240 
VVLPEPTGAD RTSIVAAAAN RTGTLAELLT ELATRGINLT RLDARPHKQN FGEYRFFIDF 

       250        260        270        280        290        300 
EGHVAEPRIA DALAALRRRC RDVRFLGSFA RADGVAATIE PAARNEDFTD AADWVAAVQR 


GEQA 

« Hide

References

[1]"Molecular cloning with a pMEA300-derived shuttle vector and characterization of the Amycolatopsis methanolica prephenate dehydratase gene."
Vrijbloed J.W., van Hylckama Vlieg J., van der Put N.M., Hessels G.I., Dijkhuizen L.
J. Bacteriol. 177:6666-6669(1995) [PubMed: 7592448] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L47666 Genomic DNA. Translation: AAA88840.1.

3D structure databases

ProteinModelPortalQ44104.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002912. ACT-bd.
IPR001086. Preph_deHydtase.
IPR018528. Preph_deHydtase_CS.
[Graphical view]
PfamPF01842. ACT. 1 hit.
PF00800. PDT. 1 hit.
[Graphical view]
PROSITEPS00857. PREPHENATE_DEHYDR_1. 1 hit.
PS00858. PREPHENATE_DEHYDR_2. False negative.
PS51171. PREPHENATE_DEHYDR_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHEA_AMYME
AccessionPrimary (citable) accession number: Q44104
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 21, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families