Q44093 (AROG_AMYME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase
EC=2.5.1.54

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase

Gene names

Name:

aroA

Organism

Amycolatopsis methanolica

Taxonomic identifier

1814 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Amycolatopsis

Protein attributes

Sequence length	203 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Sequence similarities	Belongs to the class-I DAHP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Transferase
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›203	›203	Phospho-2-dehydro-3-deoxyheptonate aldolase		PRO_0000140828
Experimental info
	Non-terminal residue	203	1

Sequences

	Sequence		Length	Mass (Da)
	Q44093 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F4F063F8BFEF7909	FASTA	203	21,886
	10 20 30 40 50 60 MIDRLVRDSR GPVTERNPPH MSLSAGPAEI SEGLDNQRTL GVSPLISPAL LRQELPVDAA 70 80 90 100 110 120 IAKTVAHGRS SAVDILHGDD DRLIVVVGPC SVHDPAAALD YAHRLAEHAA GVRDELHVIM 130 140 150 160 170 180 RVYFEKPRTT LGWKGLINDP DLDGSYAVNK GLRMARKLLL DISALGLPVG CEFLDPITPQ 190 200 FIADTVSWGS IGARTAASQV HRQ

References

[1]	"Characterization and phylogeny of the pfp gene of Amycolatopsis methanolica encoding PPi-dependent phosphofructokinase." Alves A.M., Meijer W.G., Vrijbloed J.W., Dijkhuizen L. J. Bacteriol. 178:149-155(1996) [PubMed: 8550409] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Rodrigues Alves A.M. Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31277 Genomic DNA. Translation: AAB01682.1.
3D structure databases
ProteinModelPortal	Q44093.
SMR	Q44093. Positions 36-203.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROG_AMYME

Accession

Primary (citable) accession number: Q44093

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 31, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program