Q44058 (AHYI_AERHY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-homoserine-lactone synthase
EC=2.3.1.184

Alternative name(s):
Autoinducer synthesis protein AhyI

Gene names

Name:

ahyI

Organism

Aeromonas hydrophila

Taxonomic identifier

644 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the synthesis of N-butanoyl-L-homoserine lactone (BHL), an autoinducer molecule which binds to AhyR.
Catalytic activity	An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine = [acyl-carrier-protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone.
Sequence similarities	Belongs to the autoinducer synthase family.

Ontologies

Keywords
Biological process	Autoinducer synthesis Quorum sensing
Ligand	S-adenosyl-L-methionine
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Acyl-homoserine-lactone synthase		PRO_0000210879

Sequences

	Sequence		Length	Mass (Da)
	Q44058 [UniParc]. Last modified May 1, 1999. Version 2. Checksum: F07C0DBA8201B7F2	FASTA	207	23,613
	10 20 30 40 50 60 MLVFKGKLKE HPRWEVENEL YRFRNRVFSD RLGWDVESHR GLEQDSFDTP DTHWVLIEDE 70 80 90 100 110 120 EGLCGCIRLL SCAKDYMLPS IFPTALAGEA PPRSNDVWEL TRLAIDAERA PRLGNGISEL 130 140 150 160 170 180 TCIIFREVYA FAKAQGIREL VAVVSLPVER IFRRLGLPIE RLGHRQAVDL GAVRGVGIRF 190 200 HLDERFARAV GQPLQGAYDE ARELVTE

References

[1]

"Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules." Swift S., Karlyshev A.V., Fish L., Durant E.L., Winson M.K., Chhabra S.R., Williams P., Macintyre S., Stewart G.S.A.B. J. Bacteriol. 179:5271-5281(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X89469 Genomic DNA. Translation: CAA61653.1.
3D structure databases
ProteinModelPortal	Q44058.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001690. Autoind_synth. IPR018311. Autoind_synth_CS. [Graphical view]
Pfam	PF00765. Autoind_synth. 1 hit. [Graphical view]
PRINTS	PR01549. AUTOINDCRSYN.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS00949. AUTOINDUCER_SYNTH_1. 1 hit. PS51187. AUTOINDUCER_SYNTH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AHYI_AERHY

Accession

Primary (citable) accession number: Q44058

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program