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Q44056

- BLA1_AERHY

UniProt

Q44056 - BLA1_AERHY

Protein

Beta-lactamase AER-1

Gene

aer1

Organism
Aeromonas hydrophila
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (01 Aug 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes carbenicillin. Methicillin and oxacillin are weakly hydrolyzed.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei83 – 831Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase AER-1 (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    Gene namesi
    Name:aer1
    OrganismiAeromonas hydrophila
    Taxonomic identifieri644 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 304267Beta-lactamase AER-1PRO_0000017048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi90 ↔ 137Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ44056.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni248 – 2503Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q44056-1 [UniParc]FASTAAdd to Basket

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    MYVLSVEKPT LRNKFAAGIG VVLVCVVASF IPTPVFALDT TKLIQAVQSE    50
    ESALHARVGM TVFDSNTGTT WNYRGDERFP LNSTHKTFSC AALLAKVDGK 100
    SLSLGQSVSI SKEMLVTYSP ITEKSLSPET VTFGKICQAA VSYSDNTAAN 150
    VVFDAIGGAT GFNAYMRSIG DEETQLDRKE PELNEGTPGD VRDTTTPNAM 200
    VNSLRKILLG DALSASSRSQ LTQWMLDDQV AGALLRASLP SDWKIADKTG 250
    AGGYGSRSIV AVIWPPSKQP LVVGIYITQT KASMQASNQA IARIGVVLKD 300
    TVAP 304
    Length:304
    Mass (Da):32,428
    Last modified:August 1, 1998 - v2
    Checksum:i66AD56ED45D02A41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14748 Genomic DNA. Translation: AAC09015.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14748 Genomic DNA. Translation: AAC09015.1 .

    3D structure databases

    ProteinModelPortali Q44056.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing beta-lactamases."
      Sanschagrin F., Bejaoui N., Levesque R.C.
      Antimicrob. Agents Chemother. 42:1966-1972(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: VL7711.
      Transposon: Omega7711.

    Entry informationi

    Entry nameiBLA1_AERHY
    AccessioniPrimary (citable) accession number: Q44056
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Transposable element

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3