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Q44056

- BLA1_AERHY

UniProt

Q44056 - BLA1_AERHY

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Protein
Beta-lactamase AER-1
Gene
aer1
Organism
Aeromonas hydrophila
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes carbenicillin. Methicillin and oxacillin are weakly hydrolyzed.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase AER-1 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:aer1
OrganismiAeromonas hydrophila
Taxonomic identifieri644 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737 Reviewed prediction
Add
BLAST
Chaini38 – 304267Beta-lactamase AER-1
PRO_0000017048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 137 Reviewed prediction

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ44056.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2503Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q44056-1 [UniParc]FASTAAdd to Basket

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MYVLSVEKPT LRNKFAAGIG VVLVCVVASF IPTPVFALDT TKLIQAVQSE    50
ESALHARVGM TVFDSNTGTT WNYRGDERFP LNSTHKTFSC AALLAKVDGK 100
SLSLGQSVSI SKEMLVTYSP ITEKSLSPET VTFGKICQAA VSYSDNTAAN 150
VVFDAIGGAT GFNAYMRSIG DEETQLDRKE PELNEGTPGD VRDTTTPNAM 200
VNSLRKILLG DALSASSRSQ LTQWMLDDQV AGALLRASLP SDWKIADKTG 250
AGGYGSRSIV AVIWPPSKQP LVVGIYITQT KASMQASNQA IARIGVVLKD 300
TVAP 304
Length:304
Mass (Da):32,428
Last modified:August 1, 1998 - v2
Checksum:i66AD56ED45D02A41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14748 Genomic DNA. Translation: AAC09015.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14748 Genomic DNA. Translation: AAC09015.1 .

3D structure databases

ProteinModelPortali Q44056.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing beta-lactamases."
    Sanschagrin F., Bejaoui N., Levesque R.C.
    Antimicrob. Agents Chemother. 42:1966-1972(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VL7711.
    Transposon: Omega7711.

Entry informationi

Entry nameiBLA1_AERHY
AccessioniPrimary (citable) accession number: Q44056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 16, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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