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Q44056

- BLA1_AERHY

UniProt

Q44056 - BLA1_AERHY

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Protein

Beta-lactamase AER-1

Gene

aer1

Organism
Aeromonas hydrophila
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes carbenicillin. Methicillin and oxacillin are weakly hydrolyzed.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase AER-1 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:aer1
OrganismiAeromonas hydrophila
Taxonomic identifieri644 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 304267Beta-lactamase AER-1PRO_0000017048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 137Sequence Analysis

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ44056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2503Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q44056-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYVLSVEKPT LRNKFAAGIG VVLVCVVASF IPTPVFALDT TKLIQAVQSE
60 70 80 90 100
ESALHARVGM TVFDSNTGTT WNYRGDERFP LNSTHKTFSC AALLAKVDGK
110 120 130 140 150
SLSLGQSVSI SKEMLVTYSP ITEKSLSPET VTFGKICQAA VSYSDNTAAN
160 170 180 190 200
VVFDAIGGAT GFNAYMRSIG DEETQLDRKE PELNEGTPGD VRDTTTPNAM
210 220 230 240 250
VNSLRKILLG DALSASSRSQ LTQWMLDDQV AGALLRASLP SDWKIADKTG
260 270 280 290 300
AGGYGSRSIV AVIWPPSKQP LVVGIYITQT KASMQASNQA IARIGVVLKD

TVAP
Length:304
Mass (Da):32,428
Last modified:August 1, 1998 - v2
Checksum:i66AD56ED45D02A41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14748 Genomic DNA. Translation: AAC09015.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14748 Genomic DNA. Translation: AAC09015.1 .

3D structure databases

ProteinModelPortali Q44056.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing beta-lactamases."
    Sanschagrin F., Bejaoui N., Levesque R.C.
    Antimicrob. Agents Chemother. 42:1966-1972(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VL7711.
    Transposon: Omega7711.

Entry informationi

Entry nameiBLA1_AERHY
AccessioniPrimary (citable) accession number: Q44056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 1, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3