Reviewed,
UniProtKB/Swiss-Prot Q44002 (DHET_ACEEU)
Last modified
September 22, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alcohol dehydrogenase [acceptor] EC=1.1.99.8 | ||
| Gene names |
| ||
| Organism | Acetobacter europaeus (Gluconacetobacter europaeus) | ||
| Taxonomic identifier | 33995 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconacetobacter |
Protein attributes
| Sequence length | 739 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | A primary alcohol + acceptor = an aldehyde + reduced acceptor. |
| Cofactor | Binds 1 PQQ group per subunit. PQQ is inserted between disulfide Cys-143-Cys-144 and the indole ring of Trp-281 By similarity. Binds 1 calcium ion per subunit By similarity. Binds 1 heme group per subunit By similarity. |
| Subunit structure | Heterotetramer (dehydrogenase, cytochrome, and two smaller unknown subunits) that forms the alcohol dehydrogenase complex By similarity. |
| Subcellular location | Cell membrane; Peripheral membrane protein; Periplasmic side Potential. |
| Sequence similarities | Belongs to the bacterial PQQ dehydrogenase family. Contains 1 cytochrome c domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Signal |
| Ligand | Calcium Heme Iron Metal-binding |
| Molecular function | Oxidoreductase |
| PTM | Disulfide bond PQQ |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | alcohol dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: EC calcium ion bindingInferred from electronic annotation. Source: UniProtKB-KW electron carrier activityInferred from electronic annotation. Source: InterPro heme bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 35 | 35 | Potential | ||||||||
| Chain | 36 – 739 | 704 | Alcohol dehydrogenase [acceptor] | PRO_0000025560 | |||||||
Regions | |||||||||||
| Domain | 635 – 739 | 105 | Cytochrome c | ||||||||
Sites | |||||||||||
| Active site | 344 | 1 | Proton acceptor Potential | ||||||||
| Metal binding | 217 | 1 | Calcium By similarity | ||||||||
| Metal binding | 299 | 1 | Calcium By similarity | ||||||||
| Metal binding | 655 | 1 | Iron (heme axial ligand) By similarity | ||||||||
| Binding site | 651 | 1 | Heme (covalent) By similarity | ||||||||
| Binding site | 654 | 1 | Heme (covalent) By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 143 ↔ 144 | By similarity | |||||||||
Sequences
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References
| [1] | Thurner C.A.K. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 51845 / DSM 6160 / DES11 / LMG 18890. |
Cross-references
Sequence databases | |
|---|---|
| X82894 Genomic DNA. Translation: CAA58066.1. Y09480 Genomic DNA. Translation: CAA70688.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KB0 based on UniProtKB Q46444. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.1.99.8. 264198. |
Family and domain databases | |
| InterPro | IPR009056. Cyt_c_monohaem. IPR019556. PQQ-dependent_C. IPR019551. PQQ-dependent_N. IPR018391. PQQ_beta_propeller_repeat. IPR017512. PQQ_MeOH/EtOH_DH. IPR002372. PQQ_repeat. IPR011047. Quino_AlcDH-like. IPR001479. Quinoprotein_DH_CS. [Graphical view] |
| Gene3D | G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit. G3DSA:2.140.10.10. Quinoprotein_alc_DH-like. 1 hit. |
| Pfam | PF01011. PQQ. 6 hits. PF10535. PQQ_C. 1 hit. PF10527. PQQ_N. 1 hit. [Graphical view] |
| SMART | SM00564. PQQ. 5 hits. [Graphical view] |
| TIGRFAMs | TIGR03075. PQQ_enz_alc_DH. 1 hit. |
| PROSITE | PS00363. BACTERIAL_PQQ_1. 1 hit. PS00364. BACTERIAL_PQQ_2. 1 hit. PS51007. CYTC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHET_ACEEU | ||||||||
| Accession | Primary (citable) accession number: Q44002 Secondary accession number(s): O07952 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


