Q43925 (HIS3_AZOCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:

hisI

Organism

Azotobacter chroococcum mcd 1

Taxonomic identifier

355 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Azotobacter

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 133	133	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_0000136457

Sequences

	Sequence		Length	Mass (Da)
	Q43925 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CEC538C94BE5EA34	FASTA	133	15,416
	10 20 30 40 50 60 MKDWLDEIHW NADGLVPAIA QDHKTGRILM MAWMNRESLA LTVRENRAIY WSRSRGKLWR 70 80 90 100 110 120 KGEESGHLQK VHEVRLDCDA DVIVLQVEQL GGIACHTGRE SCFYRVFEDG AWKVVEPILK 130 DPDAIYHAGH RHE

References

[1]	Yates M., Souza E.M. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U48404 Genomic DNA. Translation: AAA92106.1.
3D structure databases
ProteinModelPortal	Q43925.
SMR	Q43925. Positions 7-122.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_AZOCH

Accession

Primary (citable) accession number: Q43925

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 2, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program