Reviewed, UniProtKB/Swiss-Prot Q43908 (DDC_ACIBA)

Names and origin

Protein names

Recommended name:
    L-2,4-diaminobutyrate decarboxylase
      Short name=DABA decarboxylase
      Short name=DABA-DC
    EC=4.1.1.86

Gene names

Name:

ddc

Organism

Acinetobacter baumannii

Taxonomic identifier

470 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-2,4-diaminobutanoate = propane-1,3-diamine + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; 1,3-diaminopropane biosynthesis; 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 2/2.
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	carboxylic acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	diaminobutyrate decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	L-2,4-diaminobutyrate decarboxylase		PRO_0000147003
Amino acid modifications
	Modified residue	319	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q43908-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 900DF52FD1941B70	FASTA	510	56,244
	10 20 30 40 50 60 MVDFAEHRKA LLCNDAQSIA DYESAMGEAV KAVSAWLQNE KMYTGGSIKE LRSAISFQPS 70 80 90 100 110 120 KEGMGVQQSL QRMIELFLNK SLKVHHPHSL AHLHCPTMVM SQIAEVLINA TNQSMDSWDQ 130 140 150 160 170 180 SPAGSLMEVQ LIDWLRQKVG YGSGQAGVFT SGGTQSNLMG VLLARDWCIA KNWKDENGNP 190 200 210 220 230 240 WSVQRDGIPA EAMKNVKVIC SENAHFSVQK NMAMMGMGFQ SVVTVPVNEN AQMDVDALEK 250 260 270 280 290 300 TMAHLQAEGK VVACVVATAG TTDAGAIHPL KKIREITNKY GSWMHIDAAW GGALILSNTY 310 320 330 340 350 360 RAMLDGIELS DSITLDFHKH YFQSISCGAF LLKDEANYRF MHYEAEYLNS AYDEEHGVPN 370 380 390 400 410 420 LVSKSLQTTR RFDALKLWMT IESLGEELYG SMIDHGVKLT REVADYIKAT EGLELLVEPQ 430 440 450 460 470 480 FASVLFRVVP EGYPVEFIDS LNQNVADELF ARGEANIGVT KVGNVQSLKM TTLSPVVTVD 490 500 510 NVKNLLAQVL AEAERIKDAI ASGNYVPPID

References

[1]

"Sequence analysis of the gene encoding a novel L-2,4-diaminobutyrate decarboxylase of Acinetobacter baumannii: similarity to the group II amino acid decarboxylases." Ikai H., Yamamoto S. Arch. Microbiol. 166:128-131(1996) [PubMed: 8772175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE. Strain: ATCC 19606 / NCTC 12156 / CIP 70.34.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D55724 Genomic DNA. Translation: BAA09538.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.1.86. 191726.
Family and domain databases
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
PANTHER	PTHR11999. Pyridoxal_deC. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DDC_ACIBA

Accession

Primary (citable) accession number: Q43908

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	May 26, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)