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Q43793

- G6PDC_TOBAC

UniProt

Q43793 - G6PDC_TOBAC

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Protein

Glucose-6-phosphate 1-dehydrogenase, chloroplastic

Gene
N/A
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Enzyme regulationi

Regulated by metabolites. Post-translationally inactivated by cysteine-mediated redox modification via the ferredoxin-thioredoxin system in the light and this avoids futile cycles with photosynthetic CO2 fixation By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei150 – 1501NADP By similarity
Binding sitei253 – 2531NADP; via carbonyl oxygen By similarity
Binding sitei253 – 2531Substrate By similarity
Binding sitei321 – 3211Substrate By similarity
Binding sitei340 – 3401Substrate By similarity
Active sitei345 – 3451Proton acceptor By similarity
Binding sitei441 – 4411Substrate By similarity
Binding sitei446 – 4461Substrate By similarity
Binding sitei482 – 4821Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi116 – 1238NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase, chloroplastic (EC:1.1.1.49)
Short name:
G6PD
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 593Glucose-6-phosphate 1-dehydrogenase, chloroplasticUniRule annotationPRO_0000010441
Transit peptidei1 – ?Chloroplast Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi168 ↔ 176Redox modulation By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ43793.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ43793.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni283 – 2875Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43793-1 [UniParc]FASTAAdd to Basket

« Hide

MVTLYSSPST HSSGPVASYS NSSIGLYNYH HNKQIAVSSI LSRKFGSLQI    50
NQKPFWNAVR MQDGAVATPP SKIENETPLK KLKNGILPVA PPKEQKDTID 100
FDSNKAKSTV SITVVGASGD LAKKKIFPAL FALYYEGCLP EHFTIFGYAR 150
SKMTDAELRN MVSKTLTCRI DKRENCGEKM EQFLERCFYH SGQYDSLENF 200
AELDKKLKEH EAGRFSNRLF YLSIPPNIFI NAVRCASLSA SSAHGWTRVI 250
VEKPFGRDSE SSAALTRSLK QYLNEDQIFR IDHYLGKELV ENLSVLRFSN 300
LIFEPLWSRQ CIRNVQFIFS EDFGTEGRGG YFDHYGIIRD IMQNHLLQIL 350
ALFAMETPVS LDAEDIRNEK VKVLRSMRPL QLDDVIIGQY KCHTKGDVTY 400
PGYTDDKTVP KDSLTPTFAA AALFIDNARW DGVPFLMKAG KALHTRSAEI 450
RVQFRHVPGN LYNKNFGSDL DQATNELVIR VQPNEAIYLK INNKVPGLGM 500
RLDRSNLNLL YSARYSKEIP DAYERLLLDA IEGERRLFIR SDELDAAWSL 550
FTPVLKELED KKIVPEYYPY GSRGPIGAHY LAARYKVRWG DLV 593
Length:593
Mass (Da):67,369
Last modified:November 1, 1996 - v1
Checksum:i228A7732E510E571
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99405 mRNA. Translation: CAA67782.1.
PIRiT03244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99405 mRNA. Translation: CAA67782.1 .
PIRi T03244.

3D structure databases

ProteinModelPortali Q43793.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q43793.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a tobacco chloroplast glucose-6-phosphate dehydrogenase cDNA."
    Knight J.S., Emes M.J.
    Plant Gene Register PGR96-076
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Samsun.
    Tissue: Leaf.

Entry informationi

Entry nameiG6PDC_TOBAC
AccessioniPrimary (citable) accession number: Q43793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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