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Protein

Lysine--tRNA ligase

Gene

LYSRS

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. lysine-tRNA ligase activity Source: UniProtKB-EC
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:LYSRS
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Lysine--tRNA ligasePRO_0000152769Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ43776.
SMRiQ43776. Positions 52-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ43776.
KOiK04567.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PIRSFiPIRSF039101. LysRS2. 1 hit.
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q43776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSVSTEPL SKNALKREKK AKEKEQLEQE KKAAAVAKRQ MEQHNLPEND
60 70 80 90 100
DLDPTQYLAN RLRNIESLRE SGINPYPHKF FITMSIPEFI SRYAHLNTGE
110 120 130 140 150
FPEDIDMSLA GRVISKRASS SKLYFYELLG GGARVQVLAS ARDSDVDAVQ
160 170 180 190 200
FSNYQSGVKR GDIIGVRGYP GKSKRGELSI FAKPFIVLAP CLHMLPRRLT
210 220 230 240 250
SSIVDETRTQ NFQGITAYDT WTPGDLRNPE SYVLRDQETR YRQRYLDLMM
260 270 280 290 300
NPEVRALFRT RARIISYIRS FLDNLEFLEV ETPSMNLTAG GASARPFITH
310 320 330 340 350
HNELDTELLI RVSPELYLKK LVVGGFDRVY ELGKHFRNEG MDLTHSPEFT
360 370 380 390 400
MCELYMAYAD YNDLMDLTEQ LLSGMVKDLT GSYKIRYHAN GLDNEPIEID
410 420 430 440 450
FTPPFRKIDM LSELEKVANI SIPRDLSSES ANKHLVDVCE KFDVKCPPPH
460 470 480 490 500
TTTRLLDKLV GHFIEVNCIN PTFIINHPEI MSPLAKSRRS EPGLTERFNL
510 520 530 540 550
FVNRRELCDA YTELNDPTAQ RERFAEQLKD RQLGDDEAMD LDESFITALE
560 570 580
YGLPPTGGLG MGIDRLTMLL TDSQNVKEVI LFPAMRLQ
Length:588
Mass (Da):67,116
Last modified:November 1, 1996 - v1
Checksum:i66590227238C20CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94451 mRNA. Translation: CAA64223.1.
PIRiT07085.
RefSeqiNP_001234285.1. NM_001247356.1.
UniGeneiLes.3641.

Genome annotation databases

GeneIDi778357.
KEGGisly:778357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94451 mRNA. Translation: CAA64223.1.
PIRiT07085.
RefSeqiNP_001234285.1. NM_001247356.1.
UniGeneiLes.3641.

3D structure databases

ProteinModelPortaliQ43776.
SMRiQ43776. Positions 52-588.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi778357.
KEGGisly:778357.

Phylogenomic databases

InParanoidiQ43776.
KOiK04567.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PIRSFiPIRSF039101. LysRS2. 1 hit.
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A root-specific iron-regulated gene of tomato encodes a lysyl-tRNA-synthetase-like protein."
    Giritch A., Herbik A., Balzer H.-J., Ganal M., Stephan U.W., Baumlein H.
    Eur. J. Biochem. 244:310-317(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Bonner Beste.
    Tissue: Root.

Entry informationi

Entry nameiSYK_SOLLC
AccessioniPrimary (citable) accession number: Q43776
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.