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Q43776

- SYK_SOLLC

UniProt

Q43776 - SYK_SOLLC

Protein

Lysine--tRNA ligase

Gene

LYSRS

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. lysine-tRNA ligase activity Source: UniProtKB-EC
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligase (EC:6.1.1.6)
    Alternative name(s):
    Lysyl-tRNA synthetase
    Short name:
    LysRS
    Gene namesi
    Name:LYSRS
    OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
    Taxonomic identifieri4081 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
    ProteomesiUP000004994: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588Lysine--tRNA ligasePRO_0000152769Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ43776.
    SMRiQ43776. Positions 52-588.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK04567.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00252. Lys_tRNA_synth_class2.
    InterProiIPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR002313. Lys-tRNA-ligase_II.
    IPR018149. Lys-tRNA-synth_II_C.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view]
    PANTHERiPTHR22594. PTHR22594. 1 hit.
    PfamiPF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view]
    PRINTSiPR00982. TRNASYNTHLYS.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q43776-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSSVSTEPL SKNALKREKK AKEKEQLEQE KKAAAVAKRQ MEQHNLPEND    50
    DLDPTQYLAN RLRNIESLRE SGINPYPHKF FITMSIPEFI SRYAHLNTGE 100
    FPEDIDMSLA GRVISKRASS SKLYFYELLG GGARVQVLAS ARDSDVDAVQ 150
    FSNYQSGVKR GDIIGVRGYP GKSKRGELSI FAKPFIVLAP CLHMLPRRLT 200
    SSIVDETRTQ NFQGITAYDT WTPGDLRNPE SYVLRDQETR YRQRYLDLMM 250
    NPEVRALFRT RARIISYIRS FLDNLEFLEV ETPSMNLTAG GASARPFITH 300
    HNELDTELLI RVSPELYLKK LVVGGFDRVY ELGKHFRNEG MDLTHSPEFT 350
    MCELYMAYAD YNDLMDLTEQ LLSGMVKDLT GSYKIRYHAN GLDNEPIEID 400
    FTPPFRKIDM LSELEKVANI SIPRDLSSES ANKHLVDVCE KFDVKCPPPH 450
    TTTRLLDKLV GHFIEVNCIN PTFIINHPEI MSPLAKSRRS EPGLTERFNL 500
    FVNRRELCDA YTELNDPTAQ RERFAEQLKD RQLGDDEAMD LDESFITALE 550
    YGLPPTGGLG MGIDRLTMLL TDSQNVKEVI LFPAMRLQ 588
    Length:588
    Mass (Da):67,116
    Last modified:November 1, 1996 - v1
    Checksum:i66590227238C20CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94451 mRNA. Translation: CAA64223.1.
    PIRiT07085.
    RefSeqiNP_001234285.1. NM_001247356.1.
    UniGeneiLes.3641.

    Genome annotation databases

    GeneIDi778357.
    KEGGisly:778357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94451 mRNA. Translation: CAA64223.1 .
    PIRi T07085.
    RefSeqi NP_001234285.1. NM_001247356.1.
    UniGenei Les.3641.

    3D structure databases

    ProteinModelPortali Q43776.
    SMRi Q43776. Positions 52-588.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 778357.
    KEGGi sly:778357.

    Phylogenomic databases

    KOi K04567.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00252. Lys_tRNA_synth_class2.
    InterProi IPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR002313. Lys-tRNA-ligase_II.
    IPR018149. Lys-tRNA-synth_II_C.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view ]
    PANTHERi PTHR22594. PTHR22594. 1 hit.
    Pfami PF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view ]
    PRINTSi PR00982. TRNASYNTHLYS.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A root-specific iron-regulated gene of tomato encodes a lysyl-tRNA-synthetase-like protein."
      Giritch A., Herbik A., Balzer H.-J., Ganal M., Stephan U.W., Baumlein H.
      Eur. J. Biochem. 244:310-317(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Bonner Beste.
      Tissue: Root.

    Entry informationi

    Entry nameiSYK_SOLLC
    AccessioniPrimary (citable) accession number: Q43776
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3