SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q43744

- MDHM_BRANA

UniProt

Q43744 - MDHM_BRANA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Malate dehydrogenase, mitochondrial

Gene
MDH
Organism
Brassica napus (Rape)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621NAD By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei122 – 1221NAD By similarity
Binding sitei147 – 1471Substrate By similarity
Binding sitei181 – 1811Substrate By similarity
Binding sitei256 – 2561NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 427NAD By similarity
Nucleotide bindingi145 – 1473NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
Gene namesi
Name:MDH
OrganismiBrassica napus (Rape)
Taxonomic identifieri3708 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion Reviewed predictionAdd
BLAST
Chaini23 – 341319Malate dehydrogenase, mitochondrialPRO_0000018623Add
BLAST

Proteomic databases

PRIDEiQ43744.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ43744.
SMRiQ43744. Positions 31-338.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43744-1 [UniParc]FASTAAdd to Basket

« Hide

MFRSALVRSS ASAKQSLLRR SFSSGSVPER KVAILGAAGG IGQPLALLMK    50
LNPLVSSLSL YDIANTPGVA ADVGHINTRS QVVGYMGDDN LAKALEGADL 100
VIIPAGVPRK PGMTRDDLFN INAGIVKNLW SAIAKYCPHA LVNMISNPVN 150
STVPIAAEIF KKAGMYDEKK LFGVTTLDVV RVKTSYAGKA NVPVAEVNVP 200
AIVGHAGVTI LPLFSQATPQ AILSGDALTV TTKRTQDGGT EVEEAKAGKG 250
SATLSMAYAG ALFADACLKG LNGVPDVVEC SYVQSTITEL PFFASKVRLG 300
KNGVEEVLDL GPLSDFEKEG LEALRPGIKS TIEKGVKFAN Q 341
Length:341
Mass (Da):35,711
Last modified:November 1, 1997 - v1
Checksum:iF27AC7D2680601C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89451 mRNA. Translation: CAA61621.1.
PIRiS57958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89451 mRNA. Translation: CAA61621.1 .
PIRi S57958.

3D structure databases

ProteinModelPortali Q43744.
SMRi Q43744. Positions 31-338.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q43744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A full-length cDNA coding for mitochondrial malate dehydrogenase from Brassica napus L."
    Witt U., Gruneberg-Seiler M., Abel W.O.
    Plant Gene Register PGR95-068
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Andor.
    Tissue: Leaf.

Entry informationi

Entry nameiMDHM_BRANA
AccessioniPrimary (citable) accession number: Q43744
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi