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Protein

Trypsin inhibitor 1

Gene
N/A
Organism
Trichosanthes kirilowii (Chinese snake gourd) (Chinese cucumber)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inhibits trypsin.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei41 – 422Reactive bond

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI07.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin inhibitor 1
Alternative name(s):
TTII
Trypsin inhibitor I
OrganismiTrichosanthes kirilowii (Chinese snake gourd) (Chinese cucumber)
Taxonomic identifieri3677 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeSicyoeaeTrichosanthes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 34Sequence analysisPRO_0000033218
Signal peptidei1 – ?Sequence analysis
Peptidei35 – 6531Trypsin inhibitor 1PRO_0000033219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 56By similarity
Disulfide bondi46 ↔ 58By similarity
Disulfide bondi52 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ43667.

Structurei

3D structure databases

ProteinModelPortaliQ43667.
SMRiQ43667. Positions 38-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiIPR000737. Prot_inh_squash.
IPR011052. Proteinase_amylase_inhib_dom.
[Graphical view]
PfamiPF00299. Squash. 1 hit.
[Graphical view]
SUPFAMiSSF57027. SSF57027. 1 hit.
PROSITEiPS00286. SQUASH_INHIBITOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFVESARA GAGADEVIQL VSDGVNEYSE KMMEGVVACP RILMPCKVND
60
DCLRGCKCLS NGYCG
Length:65
Mass (Da):6,877
Last modified:November 1, 1996 - v1
Checksum:i04473A36A4AC0605
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82230 mRNA. Translation: CAA57704.1.
PIRiS49486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82230 mRNA. Translation: CAA57704.1.
PIRiS49486.

3D structure databases

ProteinModelPortaliQ43667.
SMRiQ43667. Positions 38-65.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI07.020.

Proteomic databases

PRIDEiQ43667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000737. Prot_inh_squash.
IPR011052. Proteinase_amylase_inhib_dom.
[Graphical view]
PfamiPF00299. Squash. 1 hit.
[Graphical view]
SUPFAMiSSF57027. SSF57027. 1 hit.
PROSITEiPS00286. SQUASH_INHIBITOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA sequence of the Trichosanthes trypsin inhibitor."
    Ling M.H., Chi C.W., Shaw P.C.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Maximowicz.
    Tissue: Root tuber.

Entry informationi

Entry nameiITR1_TRIKI
AccessioniPrimary (citable) accession number: Q43667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.