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Protein

HMG-Y-related protein A

Gene

HMGA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds A/T-rich DNA with a highly dynamic distribution into the nucleus.1 Publication

Caution

Lacks phosphorylation sites present in ortholog HMGA proteins.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi97 – 105A.T hook 1Curated9
DNA bindingi130 – 138A.T hook 2Curated9
DNA bindingi155 – 163A.T hook 3Curated9
DNA bindingi183 – 193A.T hook 4CuratedAdd BLAST11

GO - Molecular functioni

  • DNA binding Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HMG-Y-related protein A
Short name:
AtHMGA
Alternative name(s):
High mobility group A protein
Gene namesi
Name:HMGA
Ordered Locus Names:At1g14900Imported
ORF Names:F10B6.31Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G14900
TAIRilocus:2006862 AT1G14900

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98R → G: Loss of the nuclear accumulation. 1 Publication1
Mutagenesisi164R → G: Loss of the nuclear accumulation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004347251 – 204HMG-Y-related protein AAdd BLAST204

Post-translational modificationi

Acetylated.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ43386

PTM databases

iPTMnetiQ43386

Expressioni

Tissue specificityi

Mostly expressed in flowers (especially in styles and filaments, and, at lower levels, in sepals and ovaries) and developing siliques, and, to a lower extent, in leaves, cotyledons, lateral roots and root tips.2 Publications

Gene expression databases

ExpressionAtlasiQ43386 baseline and differential
GenevisibleiQ43386 AT

Interactioni

Protein-protein interaction databases

IntActiQ43386, 4 interactors
STRINGi3702.AT1G14900.1

Structurei

3D structure databases

ProteinModelPortaliQ43386
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 91H15PROSITE-ProRule annotationAdd BLAST70

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 102Nuclear localization signal 1 (NLS)1 Publication7
Motifi162 – 166Nuclear localization signal 2 (NLS)1 Publication5

Sequence similaritiesi

Belongs to the HMGA family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZSY Eukaryota
ENOG410YQM8 LUCA
HOGENOMiHOG000005795
OMAiMIMEAID
OrthoDBiEOG09360X5Q

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR005818 Histone_H1/H5_H15
IPR000116 HMGA
IPR031059 HMGA_plant
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11467:SF29 PTHR11467:SF29, 1 hit
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00929 ATHOOK
PR00930 HIGHMOBLTYIY
SMARTiView protein in SMART
SM00384 AT_hook, 4 hits
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q43386-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFDLHHGSA SDTHSSELPS FSLPPYPQMI MEAIESLNDK NGCNKTTIAK
60 70 80 90 100
HIESTQQTLP PSHMTLLSYH LNQMKKTGQL IMVKNNYMKP DPDAPPKRGR
110 120 130 140 150
GRPPKQKTQA ESDAAAAAVV AATVVSTDPP RSRGRPPKPK DPSEPPQEKV
160 170 180 190 200
ITGSGRPRGR PPKRPRTDSE TVAAPEPAAQ ATGERRGRGR PPKVKPTVVA

PVGC
Length:204
Mass (Da):22,011
Last modified:November 1, 1996 - v1
Checksum:i687C24CB6A9AA437
GO
Isoform 2 (identifier: Q43386-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.Imported
Show »
Length:176
Mass (Da):18,973
Checksum:iB8791E081FCEE7A7
GO

Sequence cautioni

The sequence AAM60937 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64M → T in CAA71797 (PubMed:9225863).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0579771 – 28Missing in isoform 2. Add BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10836 Genomic DNA Translation: CAA71797.1
X99116 mRNA Translation: CAA67564.1
AF041253 Genomic DNA Translation: AAB97739.1
AC006917 Genomic DNA Translation: AAF79232.1
CP002684 Genomic DNA Translation: AEE29240.1
BT004806 mRNA Translation: AAO44072.1
AK317240 mRNA Translation: BAH19921.1
AK319041 mRNA Translation: BAH57156.1
AY084355 mRNA Translation: AAM60937.1 Different initiation.
RefSeqiNP_172943.1, NM_101359.4 [Q43386-1]
UniGeneiAt.5361

Genome annotation databases

EnsemblPlantsiAT1G14900.1; AT1G14900.1; AT1G14900 [Q43386-1]
GeneIDi838055
GrameneiAT1G14900.1; AT1G14900.1; AT1G14900 [Q43386-1]
KEGGiath:AT1G14900

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHMGYA_ARATH
AccessioniPrimary (citable) accession number: Q43386
Secondary accession number(s): P92954, Q8LGC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 11, 2015
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health