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Protein

HMG-Y-related protein A

Gene

HMGA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds A/T-rich DNA with a highly dynamic distribution into the nucleus.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi97 – 105A.T hook 1Curated9
DNA bindingi130 – 138A.T hook 2Curated9
DNA bindingi155 – 163A.T hook 3Curated9
DNA bindingi183 – 193A.T hook 4CuratedAdd BLAST11

GO - Molecular functioni

  • DNA binding Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HMG-Y-related protein A
Short name:
AtHMGA
Alternative name(s):
High mobility group A protein
Gene namesi
Name:HMGA
Ordered Locus Names:At1g14900Imported
ORF Names:F10B6.31Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G14900.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication
  • Nucleusnucleolus By similarity

  • Note: Follows a highly dynamic speckled distribution pattern throughout the chromatin of interphase nuclei.1 Publication

GO - Cellular componenti

  • nucleolus Source: UniProtKB
  • nucleosome Source: InterPro
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98R → G: Loss of the nuclear accumulation. 1 Publication1
Mutagenesisi164R → G: Loss of the nuclear accumulation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004347251 – 204HMG-Y-related protein AAdd BLAST204

Post-translational modificationi

Acetylated.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ43386.

PTM databases

iPTMnetiQ43386.

Expressioni

Tissue specificityi

Mostly expressed in flowers (especially in styles and filaments, and, at lower levels, in sepals and ovaries) and developing siliques, and, to a lower extent, in leaves, cotyledons, lateral roots and root tips.2 Publications

Gene expression databases

GenevisibleiQ43386. AT.

Interactioni

Protein-protein interaction databases

IntActiQ43386. 1 interactor.
STRINGi3702.AT1G14900.1.

Structurei

3D structure databases

ProteinModelPortaliQ43386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 91H15PROSITE-ProRule annotationAdd BLAST70

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 102Nuclear localization signal 1 (NLS)1 Publication7
Motifi162 – 166Nuclear localization signal 2 (NLS)1 Publication5

Sequence similaritiesi

Belongs to the HMGA family.Curated
Contains 4 A.T hook DNA-binding domains.Curated
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZSY. Eukaryota.
ENOG410YQM8. LUCA.
HOGENOMiHOG000005795.
OMAiMIMEAID.
OrthoDBiEOG09360X5Q.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR005818. Histone_H1/H5_H15.
IPR000116. HMGA.
IPR031059. HMGA_plant.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11467:SF29. PTHR11467:SF29. 1 hit.
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiSM00384. AT_hook. 4 hits.
SM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q43386-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFDLHHGSA SDTHSSELPS FSLPPYPQMI MEAIESLNDK NGCNKTTIAK
60 70 80 90 100
HIESTQQTLP PSHMTLLSYH LNQMKKTGQL IMVKNNYMKP DPDAPPKRGR
110 120 130 140 150
GRPPKQKTQA ESDAAAAAVV AATVVSTDPP RSRGRPPKPK DPSEPPQEKV
160 170 180 190 200
ITGSGRPRGR PPKRPRTDSE TVAAPEPAAQ ATGERRGRGR PPKVKPTVVA

PVGC
Length:204
Mass (Da):22,011
Last modified:November 1, 1996 - v1
Checksum:i687C24CB6A9AA437
GO
Isoform 2 (identifier: Q43386-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.Imported
Show »
Length:176
Mass (Da):18,973
Checksum:iB8791E081FCEE7A7
GO

Sequence cautioni

The sequence AAM60937 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64M → T in CAA71797 (PubMed:9225863).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0579771 – 28Missing in isoform 2. Add BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10836 Genomic DNA. Translation: CAA71797.1.
X99116 mRNA. Translation: CAA67564.1.
AF041253 Genomic DNA. Translation: AAB97739.1.
AC006917 Genomic DNA. Translation: AAF79232.1.
CP002684 Genomic DNA. Translation: AEE29240.1.
BT004806 mRNA. Translation: AAO44072.1.
AK317240 mRNA. Translation: BAH19921.1.
AK319041 mRNA. Translation: BAH57156.1.
AY084355 mRNA. Translation: AAM60937.1. Different initiation.
RefSeqiNP_172943.1. NM_101359.4. [Q43386-1]
UniGeneiAt.5361.

Genome annotation databases

EnsemblPlantsiAT1G14900.1; AT1G14900.1; AT1G14900. [Q43386-1]
GeneIDi838055.
GrameneiAT1G14900.1; AT1G14900.1; AT1G14900.
KEGGiath:AT1G14900.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10836 Genomic DNA. Translation: CAA71797.1.
X99116 mRNA. Translation: CAA67564.1.
AF041253 Genomic DNA. Translation: AAB97739.1.
AC006917 Genomic DNA. Translation: AAF79232.1.
CP002684 Genomic DNA. Translation: AEE29240.1.
BT004806 mRNA. Translation: AAO44072.1.
AK317240 mRNA. Translation: BAH19921.1.
AK319041 mRNA. Translation: BAH57156.1.
AY084355 mRNA. Translation: AAM60937.1. Different initiation.
RefSeqiNP_172943.1. NM_101359.4. [Q43386-1]
UniGeneiAt.5361.

3D structure databases

ProteinModelPortaliQ43386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ43386. 1 interactor.
STRINGi3702.AT1G14900.1.

PTM databases

iPTMnetiQ43386.

Proteomic databases

PaxDbiQ43386.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G14900.1; AT1G14900.1; AT1G14900. [Q43386-1]
GeneIDi838055.
GrameneiAT1G14900.1; AT1G14900.1; AT1G14900.
KEGGiath:AT1G14900.

Organism-specific databases

TAIRiAT1G14900.

Phylogenomic databases

eggNOGiENOG410IZSY. Eukaryota.
ENOG410YQM8. LUCA.
HOGENOMiHOG000005795.
OMAiMIMEAID.
OrthoDBiEOG09360X5Q.

Miscellaneous databases

PROiQ43386.

Gene expression databases

GenevisibleiQ43386. AT.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR005818. Histone_H1/H5_H15.
IPR000116. HMGA.
IPR031059. HMGA_plant.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11467:SF29. PTHR11467:SF29. 1 hit.
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiSM00384. AT_hook. 4 hits.
SM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGYA_ARATH
AccessioniPrimary (citable) accession number: Q43386
Secondary accession number(s): P92954, Q8LGC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 11, 2015
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Lacks phosphorylation sites present in ortholog HMGA proteins.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.