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Protein

Glutamate dehydrogenase 1

Gene

GDH1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102PROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: TAIR
  • cobalt ion binding Source: TAIR
  • copper ion binding Source: TAIR
  • glutamate dehydrogenase (NAD+) activity Source: InterPro
  • glutamate dehydrogenase [NAD(P)+] activity Source: TAIR
  • zinc ion binding Source: TAIR

GO - Biological processi

  • cellular amino acid metabolic process Source: InterPro
  • nitrogen compound metabolic process Source: TAIR
  • response to absence of light Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT5G18170-MONOMER.
ReactomeiR-ATH-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase 1 (EC:1.4.1.3)
Short name:
GDH 1
Gene namesi
Name:GDH1
Ordered Locus Names:At5g18170
ORF Names:MRG7.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRilocus:2172309. AT5G18170.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: TAIR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001827451 – 411Glutamate dehydrogenase 1Add BLAST411

Proteomic databases

PaxDbiQ43314.
PRIDEiQ43314.

PTM databases

iPTMnetiQ43314.

Expressioni

Gene expression databases

ExpressionAtlasiQ43314. baseline and differential.
GenevisibleiQ43314. AT.

Interactioni

Protein-protein interaction databases

IntActiQ43314. 1 interactor.
STRINGi3702.AT5G18170.1.

Structurei

3D structure databases

ProteinModelPortaliQ43314.
SMRiQ43314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2250. Eukaryota.
COG0334. LUCA.
HOGENOMiHOG000243801.
InParanoidiQ43314.
KOiK00261.
OMAiVAQDNKV.
OrthoDBiEOG09360A6S.
PhylomeDBiQ43314.

Family and domain databases

CDDicd01076. NAD_bind_1_Glu_DH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
IPR033922. NAD_bind_Glu_DH.
PfamiView protein in Pfam
PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiView protein in SMART
SM00839. ELFV_dehydrog. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00074. GLFV_DEHYDROGENASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q43314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALAATNRN FKLAARLLGL DSKLEKSLLI PFREIKVECT IPKDDGTLAS
60 70 80 90 100
FVGFRVQHDN ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVAKIPYGG
110 120 130 140 150
AKGGIGCDPS KLSISELERL TRVFTQKIHD LIGIHTDVPA PDMGTGPQTM
160 170 180 190 200
AWILDEYSKF HGYSPAVVTG KPIDLGGSLG RDAATGRGVM FGTEALLNEH
210 220 230 240 250
GKTISGQRFV IQGFGNVGSW AAKLISEKGG KIVAVSDITG AIKNKDGIDI
260 270 280 290 300
PALLKHTKEH RGVKGFDGAD PIDPNSILVE DCDILVPAAL GGVINRENAN
310 320 330 340 350
EIKAKFIIEA ANHPTDPDAD EILSKKGVVI LPDIYANSGG VTVSYFEWVQ
360 370 380 390 400
NIQGFMWEEE KVNDELKTYM TRSFKDLKEM CKTHSCDLRM GAFTLGVNRV
410
AQATILRGWG A
Length:411
Mass (Da):44,524
Last modified:November 1, 1996 - v1
Checksum:i4F14E31CEC52935E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37771 mRNA. Translation: AAA82615.1.
U53527 mRNA. Translation: AAB08057.1.
AB012246 Genomic DNA. Translation: BAB09475.1.
CP002688 Genomic DNA. Translation: AED92515.1.
PIRiS71217.
RefSeqiNP_197318.1. NM_121822.4.
UniGeneiAt.23609.

Genome annotation databases

EnsemblPlantsiAT5G18170.1; AT5G18170.1; AT5G18170.
GeneIDi831935.
GrameneiAT5G18170.1; AT5G18170.1; AT5G18170.
KEGGiath:AT5G18170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37771 mRNA. Translation: AAA82615.1.
U53527 mRNA. Translation: AAB08057.1.
AB012246 Genomic DNA. Translation: BAB09475.1.
CP002688 Genomic DNA. Translation: AED92515.1.
PIRiS71217.
RefSeqiNP_197318.1. NM_121822.4.
UniGeneiAt.23609.

3D structure databases

ProteinModelPortaliQ43314.
SMRiQ43314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ43314. 1 interactor.
STRINGi3702.AT5G18170.1.

PTM databases

iPTMnetiQ43314.

Proteomic databases

PaxDbiQ43314.
PRIDEiQ43314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G18170.1; AT5G18170.1; AT5G18170.
GeneIDi831935.
GrameneiAT5G18170.1; AT5G18170.1; AT5G18170.
KEGGiath:AT5G18170.

Organism-specific databases

AraportiAT5G18170.
TAIRilocus:2172309. AT5G18170.

Phylogenomic databases

eggNOGiKOG2250. Eukaryota.
COG0334. LUCA.
HOGENOMiHOG000243801.
InParanoidiQ43314.
KOiK00261.
OMAiVAQDNKV.
OrthoDBiEOG09360A6S.
PhylomeDBiQ43314.

Enzyme and pathway databases

BioCyciARA:AT5G18170-MONOMER.
ReactomeiR-ATH-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

PROiPR:Q43314.

Gene expression databases

ExpressionAtlasiQ43314. baseline and differential.
GenevisibleiQ43314. AT.

Family and domain databases

CDDicd01076. NAD_bind_1_Glu_DH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
IPR033922. NAD_bind_Glu_DH.
PfamiView protein in Pfam
PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiView protein in SMART
SM00839. ELFV_dehydrog. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00074. GLFV_DEHYDROGENASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHE1_ARATH
AccessioniPrimary (citable) accession number: Q43314
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 12, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.