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Q43314

- DHE1_ARATH

UniProt

Q43314 - DHE1_ARATH

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Protein

Glutamate dehydrogenase 1

Gene

GDH1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: TAIR
  2. cobalt ion binding Source: TAIR
  3. copper ion binding Source: TAIR
  4. glutamate dehydrogenase [NAD(P)+] activity Source: TAIR
  5. zinc ion binding Source: TAIR

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
  2. nitrogen compound metabolic process Source: TAIR
  3. response to absence of light Source: TAIR
  4. response to cadmium ion Source: TAIR
  5. response to salt stress Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT5G18170-MONOMER.
ReactomeiREACT_232680. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase 1 (EC:1.4.1.3)
Short name:
GDH 1
Gene namesi
Name:GDH1
Ordered Locus Names:At5g18170
ORF Names:MRG7.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G18170.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Glutamate dehydrogenase 1PRO_0000182745Add
BLAST

Proteomic databases

PaxDbiQ43314.
PRIDEiQ43314.

Expressioni

Gene expression databases

GenevestigatoriQ43314.

Interactioni

Protein-protein interaction databases

IntActiQ43314. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ43314.
SMRiQ43314. Positions 11-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243801.
InParanoidiQ43314.
KOiK00261.
OMAiNANDIMA.
PhylomeDBiQ43314.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q43314-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNALAATNRN FKLAARLLGL DSKLEKSLLI PFREIKVECT IPKDDGTLAS
60 70 80 90 100
FVGFRVQHDN ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVAKIPYGG
110 120 130 140 150
AKGGIGCDPS KLSISELERL TRVFTQKIHD LIGIHTDVPA PDMGTGPQTM
160 170 180 190 200
AWILDEYSKF HGYSPAVVTG KPIDLGGSLG RDAATGRGVM FGTEALLNEH
210 220 230 240 250
GKTISGQRFV IQGFGNVGSW AAKLISEKGG KIVAVSDITG AIKNKDGIDI
260 270 280 290 300
PALLKHTKEH RGVKGFDGAD PIDPNSILVE DCDILVPAAL GGVINRENAN
310 320 330 340 350
EIKAKFIIEA ANHPTDPDAD EILSKKGVVI LPDIYANSGG VTVSYFEWVQ
360 370 380 390 400
NIQGFMWEEE KVNDELKTYM TRSFKDLKEM CKTHSCDLRM GAFTLGVNRV
410
AQATILRGWG A
Length:411
Mass (Da):44,524
Last modified:November 1, 1996 - v1
Checksum:i4F14E31CEC52935E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37771 mRNA. Translation: AAA82615.1.
U53527 mRNA. Translation: AAB08057.1.
AB012246 Genomic DNA. Translation: BAB09475.1.
CP002688 Genomic DNA. Translation: AED92515.1.
PIRiS71217.
RefSeqiNP_197318.1. NM_121822.3.
UniGeneiAt.23609.

Genome annotation databases

EnsemblPlantsiAT5G18170.1; AT5G18170.1; AT5G18170.
GeneIDi831935.
KEGGiath:AT5G18170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37771 mRNA. Translation: AAA82615.1 .
U53527 mRNA. Translation: AAB08057.1 .
AB012246 Genomic DNA. Translation: BAB09475.1 .
CP002688 Genomic DNA. Translation: AED92515.1 .
PIRi S71217.
RefSeqi NP_197318.1. NM_121822.3.
UniGenei At.23609.

3D structure databases

ProteinModelPortali Q43314.
SMRi Q43314. Positions 11-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q43314. 1 interaction.

Proteomic databases

PaxDbi Q43314.
PRIDEi Q43314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G18170.1 ; AT5G18170.1 ; AT5G18170 .
GeneIDi 831935.
KEGGi ath:AT5G18170.

Organism-specific databases

GeneFarmi 2257. 178.
TAIRi AT5G18170.

Phylogenomic databases

eggNOGi COG0334.
HOGENOMi HOG000243801.
InParanoidi Q43314.
KOi K00261.
OMAi NANDIMA.
PhylomeDBi Q43314.

Enzyme and pathway databases

BioCyci ARA:AT5G18170-MONOMER.
Reactomei REACT_232680. Amino acid synthesis and interconversion (transamination).

Gene expression databases

Genevestigatori Q43314.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Arabidopsis glutamate dehydrogenase 1."
    Thakkar S., Weisemann J.M., Turano F.J.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Arabidopsis mutant analysis and gene regulation define a nonredundant role for glutamate dehydrogenase in nitrogen assimilation."
    Melo-Oliveira R., Oliveira I., Coruzzi G.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  3. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
    Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
    DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiDHE1_ARATH
AccessioniPrimary (citable) accession number: Q43314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3