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Protein

Glutamate dehydrogenase 1

Gene

GDH1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102PROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: TAIR
  • cobalt ion binding Source: TAIR
  • copper ion binding Source: TAIR
  • glutamate dehydrogenase [NAD(P)+] activity Source: TAIR
  • zinc ion binding Source: TAIR

GO - Biological processi

  • cellular amino acid metabolic process Source: InterPro
  • nitrogen compound metabolic process Source: TAIR
  • response to absence of light Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT5G18170-MONOMER
ReactomeiR-ATH-2151201 Transcriptional activation of mitochondrial biogenesis
R-ATH-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase 1 (EC:1.4.1.3)
Short name:
GDH 1
Gene namesi
Name:GDH1
Ordered Locus Names:At5g18170
ORF Names:MRG7.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G18170
TAIRilocus:2172309 AT5G18170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001827451 – 411Glutamate dehydrogenase 1Add BLAST411

Proteomic databases

PaxDbiQ43314
PRIDEiQ43314

PTM databases

iPTMnetiQ43314

Expressioni

Gene expression databases

ExpressionAtlasiQ43314 baseline and differential
GenevisibleiQ43314 AT

Interactioni

Protein-protein interaction databases

IntActiQ43314, 1 interactor
STRINGi3702.AT5G18170.1

Structurei

3D structure databases

ProteinModelPortaliQ43314
SMRiQ43314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2250 Eukaryota
COG0334 LUCA
HOGENOMiHOG000243801
InParanoidiQ43314
KOiK00261
OMAiAHECEVL
OrthoDBiEOG09360A6S
PhylomeDBiQ43314

Family and domain databases

CDDicd01076 NAD_bind_1_Glu_DH, 1 hit
InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR014362 Glu_DH
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PIRSFiPIRSF000185 Glu_DH, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q43314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALAATNRN FKLAARLLGL DSKLEKSLLI PFREIKVECT IPKDDGTLAS
60 70 80 90 100
FVGFRVQHDN ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVAKIPYGG
110 120 130 140 150
AKGGIGCDPS KLSISELERL TRVFTQKIHD LIGIHTDVPA PDMGTGPQTM
160 170 180 190 200
AWILDEYSKF HGYSPAVVTG KPIDLGGSLG RDAATGRGVM FGTEALLNEH
210 220 230 240 250
GKTISGQRFV IQGFGNVGSW AAKLISEKGG KIVAVSDITG AIKNKDGIDI
260 270 280 290 300
PALLKHTKEH RGVKGFDGAD PIDPNSILVE DCDILVPAAL GGVINRENAN
310 320 330 340 350
EIKAKFIIEA ANHPTDPDAD EILSKKGVVI LPDIYANSGG VTVSYFEWVQ
360 370 380 390 400
NIQGFMWEEE KVNDELKTYM TRSFKDLKEM CKTHSCDLRM GAFTLGVNRV
410
AQATILRGWG A
Length:411
Mass (Da):44,524
Last modified:November 1, 1996 - v1
Checksum:i4F14E31CEC52935E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37771 mRNA Translation: AAA82615.1
U53527 mRNA Translation: AAB08057.1
AB012246 Genomic DNA Translation: BAB09475.1
CP002688 Genomic DNA Translation: AED92515.1
PIRiS71217
RefSeqiNP_197318.1, NM_121822.4
UniGeneiAt.23609

Genome annotation databases

EnsemblPlantsiAT5G18170.1; AT5G18170.1; AT5G18170
GeneIDi831935
GrameneiAT5G18170.1; AT5G18170.1; AT5G18170
KEGGiath:AT5G18170

Similar proteinsi

Entry informationi

Entry nameiDHE1_ARATH
AccessioniPrimary (citable) accession number: Q43314
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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