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Protein

Protein H2A.7

Gene

H2A-4

more
Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein H2A.7
Alternative name(s):
wcH2A-10
wcH2A-4
Gene namesi
Name:H2A-4
AND
Name:H2A-10
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002446502 – 134Protein H2A.7Add BLAST133

Proteomic databases

PRIDEiQ43312

Expressioni

Tissue specificityi

Expressed in meristematic and non-proliferating tissues.1 Publication

Developmental stagei

Constant expression during germination.1 Publication

Gene expression databases

ExpressionAtlasiQ43312 baseline
GenevisibleiQ43312 TA

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ43312
SMRiQ43312
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

OMAiRICFYSM
OrthoDBiEOG09360WU4

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGKAIGS GAAKKAISRS SKAGLQFPVG RIARFLKAGK YAERVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI VPRHIQLAVR NDEELSRLLG
110 120 130
MVTIASGGVM PNIHNLLLPK KAGGSKAVAA DDDS
Length:134
Mass (Da):13,932
Last modified:January 23, 2007 - v3
Checksum:iC50BB80F046C4032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38091 mRNA Translation: BAA07280.1
D38089 mRNA Translation: BAA07278.1
PIRiS53521
UniGeneiTa.35717

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330
TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610
GrameneiTRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330
TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610

Similar proteinsi

Entry informationi

Entry nameiH2A7_WHEAT
AccessioniPrimary (citable) accession number: Q43312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health