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Protein

Protein H2A.7

Gene

H2A-4

more
Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein H2A.7
Alternative name(s):
wcH2A-10
wcH2A-4
Gene namesi
Name:H2A-4
AND
Name:H2A-10
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002446502 – 134Protein H2A.7Add BLAST133

Proteomic databases

PRIDEiQ43312.

Expressioni

Tissue specificityi

Expressed in meristematic and non-proliferating tissues.1 Publication

Developmental stagei

Constant expression during germination.1 Publication

Gene expression databases

GenevisibleiQ43312. TA.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Structurei

3D structure databases

ProteinModelPortaliQ43312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

OrthoDBiEOG09360WU4.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGKAIGS GAAKKAISRS SKAGLQFPVG RIARFLKAGK YAERVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI VPRHIQLAVR NDEELSRLLG
110 120 130
MVTIASGGVM PNIHNLLLPK KAGGSKAVAA DDDS
Length:134
Mass (Da):13,932
Last modified:January 23, 2007 - v3
Checksum:iC50BB80F046C4032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38091 mRNA. Translation: BAA07280.1.
D38089 mRNA. Translation: BAA07278.1.
PIRiS53521.
UniGeneiTa.35717.

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.
TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.
GrameneiTRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.
TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38091 mRNA. Translation: BAA07280.1.
D38089 mRNA. Translation: BAA07278.1.
PIRiS53521.
UniGeneiTa.35717.

3D structure databases

ProteinModelPortaliQ43312.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ43312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.
TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.
GrameneiTRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.1; TRIAE_CS42_2AS_TGACv1_113113_AA0351380.
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.1; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.
TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.2; TRIAE_CS42_2BS_TGACv1_147373_AA0482330.
TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.1; TRIAE_CS42_2DS_TGACv1_179916_AA0609610.

Phylogenomic databases

OrthoDBiEOG09360WU4.

Gene expression databases

GenevisibleiQ43312. TA.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2A7_WHEAT
AccessioniPrimary (citable) accession number: Q43312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.