Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate dehydrogenase

Gene

GDH1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021PROSITE-ProRule annotation

GO - Molecular functioni

  1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase (EC:1.4.1.3)
Short name:
GDH
Gene namesi
Name:GDH1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea
ProteomesiUP000007305: Unplaced

Organism-specific databases

GrameneiQ43260.
MaizeGDBi12238.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi188 – 1881G → R in GDH1.
Mutagenesisi246 – 2461D → G in GDH1.
Mutagenesisi252 – 2532QL → EV in GDH1.
Mutagenesisi367 – 3671R → Q in GDH1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Glutamate dehydrogenasePRO_0000182749Add
BLAST

Proteomic databases

PRIDEiQ43260.

Structurei

3D structure databases

ProteinModelPortaliQ43260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000243801.
KOiK00261.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q43260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALAATSRN FKQAAKLLGL DSKLEKSLLI PFREIKVECT IPKDDGTLAS
60 70 80 90 100
YVGFRVQHDN ARGPMKGGIR YHHEVDPDEV NALAQLMTWK TAVANIPYGG
110 120 130 140 150
AKGGIGCSPG DLSISELERL TRVFTQKIHD LIGIHTDVPA PDMGTNSQTM
160 170 180 190 200
AWILDEYSKF HGYSPAVVTG KPVDLGGSLG RDAATGRGVL FATEALLAEH
210 220 230 240 250
GKGIAGQRFV IQGFGNVGSW AAQLISEAGG KVIAISDVTG AVKNVDGLDI
260 270 280 290 300
AQLVKHSAEN KGIKGFKGGD AIAPDSLLTE ECDVLIPAAL GGVINKDNAN
310 320 330 340 350
DIKAKYIIEA ANHPTDPEAD EILSKKGVLI LPDILANSGG VTVSYFEWVQ
360 370 380 390 400
NIQGFMWDEE KVNAELRTYI TRAFGNVKQM CRSHSCDLRM GAFTLGVNRV
410
ARATVLRGWE A
Length:411
Mass (Da):44,022
Last modified:November 1, 1996 - v1
Checksum:i648C67A9338922CF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181L → V in strain: cv. P-10 Inbred.
Natural varianti370 – 3701I → M in strain: cv. P-10 Inbred.
Natural varianti376 – 3761N → D in strain: cv. P-10 Inbred.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49475 mRNA. Translation: BAA08445.1.
U93560 mRNA. Translation: AAB51595.1.
U93561 mRNA. Translation: AAB51596.1.
PIRiT03294.
T04342.
RefSeqiNP_001105301.1. NM_001111831.1.
UniGeneiZm.160907.

Genome annotation databases

GeneIDi542220.
KEGGizma:542220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49475 mRNA. Translation: BAA08445.1.
U93560 mRNA. Translation: AAB51595.1.
U93561 mRNA. Translation: AAB51596.1.
PIRiT03294.
T04342.
RefSeqiNP_001105301.1. NM_001111831.1.
UniGeneiZm.160907.

3D structure databases

ProteinModelPortaliQ43260.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ43260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi542220.
KEGGizma:542220.

Organism-specific databases

GrameneiQ43260.
MaizeGDBi12238.

Phylogenomic databases

HOGENOMiHOG000243801.
KOiK00261.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of a cDNA that encodes maize glutamate dehydrogenase."
    Sakakibara H., Fujii K., Sugiyama T.
    Plant Cell Physiol. 36:789-797(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Golden cross Bantam T51.
    Tissue: Root.
  2. "Characterization of a GDH1-mutant in maize."
    Ju G.C.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTANT GDH1.
    Strain: cv. P-10 Inbred.
    Tissue: Shoot.

Entry informationi

Entry nameiDHE3_MAIZE
AccessioniPrimary (citable) accession number: Q43260
Secondary accession number(s): O04871, O04872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.