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Q43260

- DHE3_MAIZE

UniProt

Q43260 - DHE3_MAIZE

Protein

Glutamate dehydrogenase

Gene

GDH1

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei102 – 1021PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: EnsemblPlants/Gramene
    2. cobalt ion binding Source: EnsemblPlants/Gramene
    3. copper ion binding Source: EnsemblPlants/Gramene
    4. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC
    5. zinc ion binding Source: EnsemblPlants/Gramene

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro
    2. regulation of nitrogen compound metabolic process Source: EnsemblPlants/Gramene
    3. response to absence of light Source: EnsemblPlants/Gramene
    4. response to cadmium ion Source: EnsemblPlants/Gramene
    5. response to salt stress Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate dehydrogenase (EC:1.4.1.3)
    Short name:
    GDH
    Gene namesi
    Name:GDH1
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiQ43260.
    MaizeGDBi12238.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: EnsemblPlants/Gramene

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi188 – 1881G → R in GDH1.
    Mutagenesisi246 – 2461D → G in GDH1.
    Mutagenesisi252 – 2532QL → EV in GDH1.
    Mutagenesisi367 – 3671R → Q in GDH1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Glutamate dehydrogenasePRO_0000182749Add
    BLAST

    Proteomic databases

    PRIDEiQ43260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ43260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000243801.
    KOiK00261.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q43260-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNALAATSRN FKQAAKLLGL DSKLEKSLLI PFREIKVECT IPKDDGTLAS    50
    YVGFRVQHDN ARGPMKGGIR YHHEVDPDEV NALAQLMTWK TAVANIPYGG 100
    AKGGIGCSPG DLSISELERL TRVFTQKIHD LIGIHTDVPA PDMGTNSQTM 150
    AWILDEYSKF HGYSPAVVTG KPVDLGGSLG RDAATGRGVL FATEALLAEH 200
    GKGIAGQRFV IQGFGNVGSW AAQLISEAGG KVIAISDVTG AVKNVDGLDI 250
    AQLVKHSAEN KGIKGFKGGD AIAPDSLLTE ECDVLIPAAL GGVINKDNAN 300
    DIKAKYIIEA ANHPTDPEAD EILSKKGVLI LPDILANSGG VTVSYFEWVQ 350
    NIQGFMWDEE KVNAELRTYI TRAFGNVKQM CRSHSCDLRM GAFTLGVNRV 400
    ARATVLRGWE A 411
    Length:411
    Mass (Da):44,022
    Last modified:November 1, 1996 - v1
    Checksum:i648C67A9338922CF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181L → V in strain: cv. P-10 Inbred.
    Natural varianti370 – 3701I → M in strain: cv. P-10 Inbred.
    Natural varianti376 – 3761N → D in strain: cv. P-10 Inbred.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49475 mRNA. Translation: BAA08445.1.
    U93560 mRNA. Translation: AAB51595.1.
    U93561 mRNA. Translation: AAB51596.1.
    PIRiT03294.
    T04342.
    RefSeqiNP_001105301.1. NM_001111831.1.
    UniGeneiZm.160907.

    Genome annotation databases

    GeneIDi542220.
    KEGGizma:542220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49475 mRNA. Translation: BAA08445.1 .
    U93560 mRNA. Translation: AAB51595.1 .
    U93561 mRNA. Translation: AAB51596.1 .
    PIRi T03294.
    T04342.
    RefSeqi NP_001105301.1. NM_001111831.1.
    UniGenei Zm.160907.

    3D structure databases

    ProteinModelPortali Q43260.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q43260.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 542220.
    KEGGi zma:542220.

    Organism-specific databases

    Gramenei Q43260.
    MaizeGDBi 12238.

    Phylogenomic databases

    HOGENOMi HOG000243801.
    KOi K00261.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a cDNA that encodes maize glutamate dehydrogenase."
      Sakakibara H., Fujii K., Sugiyama T.
      Plant Cell Physiol. 36:789-797(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Golden cross Bantam T51.
      Tissue: Root.
    2. "Characterization of a GDH1-mutant in maize."
      Ju G.C.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTANT GDH1.
      Strain: cv. P-10 Inbred.
      Tissue: Shoot.

    Entry informationi

    Entry nameiDHE3_MAIZE
    AccessioniPrimary (citable) accession number: Q43260
    Secondary accession number(s): O04871, O04872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3