Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q43240 (TCMO_ZINEL) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trans-cinnamate 4-monooxygenase

EC=1.14.13.11
Alternative name(s):
Cinnamic acid 4-hydroxylase
Short name=C4H
Short name=CA4H
Cytochrome P450 73
Cytochrome P450C4H
Gene names
Name:CYP73A12
OrganismZinnia elegans (Zinnia)
Taxonomic identifier34245 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeZinnia

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Controls carbon flux to pigments essential for pollination or UV protection, to numerous pytoalexins synthesized by plants when challenged by pathogens, and to lignins.

Catalytic activity

Trans-cinnamate + NADPH + O2 = 4-hydroxycinnamate + NADP+ + H2O.

Cofactor

Heme group By similarity.

Pathway

Phenylpropanoid metabolism; trans-4-coumarate biosynthesis; trans-4-coumarate from trans-cinnamate: step 1/1.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Trans-cinnamate 4-monooxygenase
PRO_0000052255

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q43240 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C51AAAEBD36C55C8

FASTA50557,914
        10         20         30         40         50         60 
MDLLLVEKTL LALFAAIIAS IFISKLRGKR FKLPPGPVPV PIFGNWLQVG DDLNHRNLTD 

        70         80         90        100        110        120 
LAKKFGEIFL LRMGQRNLVV VSSPNLAKEV LHTQGVEFGS RTRNVVFDIF TGKGQDMVFT 

       130        140        150        160        170        180 
VYGEHWRKMR RIMTVPFFTN KVVQQYRTGW EAEAAAVVDD VKKNPKAATE GVVIRKRLQL 

       190        200        210        220        230        240 
MMYNNMFRIM FDRRFESEDD PLFVKLKMLN GERSRLAQSF EYNYGDFIPI LRPFLKGYLK 

       250        260        270        280        290        300 
LCKEVKEKRF QLFKDYFVDE RKKLGSTKSM DNNQLKCAID HILDAKDKGE INEDNVLYIV 

       310        320        330        340        350        360 
ENINVAAIET TLWSIEWAIA ELVNHPEIQA KLRHELVSQL GPGVQVTEPD LHKLPYLQAV 

       370        380        390        400        410        420 
IKETLRLRMA IPLLVPHMNL HDAKLGGYDI PAESKILVNA WWLANNPDQW KKPEEFRPER 

       430        440        450        460        470        480 
FLEEESKVEA NGNDFRYLPF GVGRRSCPGI ILALPILGIT IGRLVQNFEL LPPPGQDKVD 

       490        500 
TTEKGGQFSL HILKHSTIVA KPRVL 

« Hide

References

[1]"Expression patterns of cinnamic acid 4-hydroxylase gene during lignification in Zinnia elegans."
Ye Z.-H., Varner J.E.
Plant Sci. 121:133-141(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Peter Pan.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19922 mRNA. Translation: AAB42024.1.

3D structure databases

ProteinModelPortalQ43240.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. Cytochrome_P450. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTCMO_ZINEL
AccessionPrimary (citable) accession number: Q43240
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 21, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families