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Protein

Histone H2B.4

Gene

TH153

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Miscellaneous

Phosphorylation of H2B was not detected.

Caution

To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-8; H2BK33ac = acetylated Lys-24; H2BK143ub1 = monoubiquitinated Lys-131.Curated

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B.4
Alternative name(s):
H2B153
Gene namesi
Name:TH153
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002454552 – 135Histone H2B.4Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Cross-linki131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Can be acetylated to form H2BK6ac and H2BK33ac.By similarity
Monoubiquitinated to form H2BK143ub1; may give a specific tag for epigenetic transcriptional activation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiQ43215

Expressioni

Tissue specificityi

Expressed preferentially in meristematic tissues.1 Publication

Gene expression databases

ExpressionAtlasiQ43215 baseline and differential

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ43215
SMRiQ43215
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKAAEKKP VEKTPAVKKP KAEKKVPTSK EGGEKKGKKK SKKSMETYKI
60 70 80 90 100
YIFKVLKQVH PDIGISSKAM SITNSFINDI FEKLAGESAK LARYNKKPTI
110 120 130
TSREIQTSVR LVLPGELAKH AVSEGTKAVT KFTSA
Length:135
Mass (Da):14,816
Last modified:January 23, 2007 - v3
Checksum:i43DC342BE31740BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37945 Genomic DNA Translation: BAA07159.1
PIRiS56687

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_3B_TGACv1_221696_AA0747690.1; TRIAE_CS42_3B_TGACv1_221696_AA0747690.1; TRIAE_CS42_3B_TGACv1_221696_AA0747690
GrameneiTRIAE_CS42_3B_TGACv1_221696_AA0747690.1; TRIAE_CS42_3B_TGACv1_221696_AA0747690.1; TRIAE_CS42_3B_TGACv1_221696_AA0747690

Similar proteinsi

Entry informationi

Entry nameiH2B4_WHEAT
AccessioniPrimary (citable) accession number: Q43215
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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