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Protein

Histone H2A.4

Gene

TH254

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.4
Gene namesi
Name:TH254
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002446472 – 135Histone H2A.4Add BLAST134

Proteomic databases

PRIDEiQ43208

Expressioni

Tissue specificityi

Expressed preferentially in meristematic tissues of young seedlings, in stigma and ovary but not in pollen.1 Publication

Developmental stagei

S phase-specific expression.1 Publication

Gene expression databases

ExpressionAtlasiQ43208 baseline

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ43208
SMRiQ43208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGKAIGA GAAKKATSRS SKAGLQFPVG RIARFLKAGK YAERVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI VPRHIQLAVR NDEELTKLLG
110 120 130
GATIASGGVM PNIHQHLLPK KASSSKVSTV DDDDN
Length:135
Mass (Da):14,102
Last modified:January 23, 2007 - v3
Checksum:i4E399E56AC19CFF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94693 Genomic DNA Translation: CAA64356.1
L75824 Genomic DNA Translation: AAL40108.1
PIRiT06511

Similar proteinsi

Entry informationi

Entry nameiH2A4_WHEAT
AccessioniPrimary (citable) accession number: Q43208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 72 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health