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Protein

70 kDa peptidyl-prolyl isomerase

Gene

FKBP70

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
70 kDa peptidyl-prolyl isomerase (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:FKBP70
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000753351 – 55970 kDa peptidyl-prolyl isomeraseAdd BLAST559

Expressioni

Inductioni

By heat shock.

Interactioni

Subunit structurei

This PPIase probably binds calmodulin.

Structurei

Secondary structure

1559
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 36Combined sources3
Beta strandi62 – 66Combined sources5
Turni91 – 94Combined sources4
Helixi100 – 106Combined sources7
Beta strandi112 – 116Combined sources5
Beta strandi139 – 148Combined sources10
Beta strandi150 – 152Combined sources3
Beta strandi155 – 165Combined sources11
Beta strandi168 – 170Combined sources3
Beta strandi178 – 187Combined sources10
Beta strandi192 – 202Combined sources11
Helixi203 – 205Combined sources3
Beta strandi207 – 209Combined sources3
Helixi210 – 216Combined sources7
Beta strandi224 – 229Combined sources6
Helixi231 – 233Combined sources3
Turni234 – 238Combined sources5
Beta strandi255 – 265Combined sources11
Beta strandi267 – 271Combined sources5
Beta strandi276 – 282Combined sources7
Beta strandi285 – 287Combined sources3
Beta strandi295 – 307Combined sources13
Beta strandi309 – 314Combined sources6
Beta strandi322 – 324Combined sources3
Turni325 – 328Combined sources4
Helixi332 – 338Combined sources7
Beta strandi346 – 351Combined sources6
Helixi353 – 355Combined sources3
Turni356 – 359Combined sources4
Beta strandi362 – 368Combined sources7
Beta strandi374 – 384Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JXVX-ray2.08A31-386[»]
3JYMX-ray2.28A/B15-391[»]
ProteinModelPortaliQ43207.
SMRiQ43207.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ43207.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 148PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini176 – 265PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST90
Domaini293 – 384PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST92
Repeati401 – 434TPR 1Add BLAST34
Repeati450 – 483TPR 2Add BLAST34
Repeati484 – 517TPR 3Add BLAST34

Sequence similaritiesi

Contains 3 PPIase FKBP-type domains.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 3 hits.
PF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 3 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q43207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDFDIPAG DDMMMGDGMG DFGGAEGPGM KVGEENEIGK QGLKKKLLKE
60 70 80 90 100
GEGWDTPEVG DEVEVHYTGT LLDGKKFDSS RDRDDTFKFK LGQGQVIKGW
110 120 130 140 150
DQGIKTMKKG ENALFTIPPE LAYGESGSPP TIPANATLQF DVELLSWTSV
160 170 180 190 200
RDIAKDGGIF KKILKEGDKW ENPKDPDEVF VKYEARLEDG TVVSKSEGVE
210 220 230 240 250
FTVKDGHLCP ALAKAVKTMK KGEKVLLAVK PQYGFGEMGR PAAGEGGAVP
260 270 280 290 300
PNASLVIDLE LVSWKTVTEI GDDKKILKKV LKEXEGYERP NEGAVVTVKI
310 320 330 340 350
TGKLQDGTVF LKKGHDEQEP FEFKTDEEAV IEGLDRAVLN MKKGEVALVT
360 370 380 390 400
IPPEYAYGST ESKQDAIVPP NSTVIYEVEL VSFVKDKESW DLNNSEKIEA
410 420 430 440 450
AGTKKEEGNA LFKSGKYARA SKRYEKAAKF IEYDTSFSED EKKQSKQLKI
460 470 480 490 500
TCNLNNAACK LKLKDYKQAE KLCTKVLELD SRNVKALYRR AQAYTQLADL
510 520 530 540 550
ELAEVDIKKA LEIDPENRDV KLTYKTLKEK IKEINKKDAK FYSNMFSKMT

KPSAEESKA
Length:559
Mass (Da):62,058
Last modified:November 1, 1996 - v1
Checksum:i5C5DAE70D716B541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86903 mRNA. Translation: CAA60505.1.
PIRiS55383.
UniGeneiTa.55812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86903 mRNA. Translation: CAA60505.1.
PIRiS55383.
UniGeneiTa.55812.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JXVX-ray2.08A31-386[»]
3JYMX-ray2.28A/B15-391[»]
ProteinModelPortaliQ43207.
SMRiQ43207.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ43207.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 3 hits.
PF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 3 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKB70_WHEAT
AccessioniPrimary (citable) accession number: Q43207
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.