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Q43207 (FKB70_WHEAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
70 kDa peptidyl-prolyl isomerase

EC=5.2.1.8
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase
Gene names
Name:FKBP70
OrganismTriticum aestivum (Wheat) [Complete proteome]
Taxonomic identifier4565 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Subunit structure

This PPIase probably binds calmodulin.

Induction

By heat shock.

Sequence similarities

Contains 3 PPIase FKBP-type domains.

Contains 3 TPR repeats.

Ontologies

Keywords
   Biological processStress response
   DomainRepeat
TPR repeat
   LigandCalmodulin-binding
   Molecular functionIsomerase
Rotamase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processcellular heat acclimation

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

protein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentvacuole

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 55955970 kDa peptidyl-prolyl isomerase
PRO_0000075335

Regions

Domain60 – 14889PPIase FKBP-type 1
Domain176 – 26590PPIase FKBP-type 2
Domain293 – 38492PPIase FKBP-type 3
Repeat401 – 43434TPR 1
Repeat450 – 48334TPR 2
Repeat484 – 51734TPR 3

Secondary structure

.......................................................... 559
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q43207 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5C5DAE70D716B541

FASTA55962,058
        10         20         30         40         50         60 
MDDDFDIPAG DDMMMGDGMG DFGGAEGPGM KVGEENEIGK QGLKKKLLKE GEGWDTPEVG 

        70         80         90        100        110        120 
DEVEVHYTGT LLDGKKFDSS RDRDDTFKFK LGQGQVIKGW DQGIKTMKKG ENALFTIPPE 

       130        140        150        160        170        180 
LAYGESGSPP TIPANATLQF DVELLSWTSV RDIAKDGGIF KKILKEGDKW ENPKDPDEVF 

       190        200        210        220        230        240 
VKYEARLEDG TVVSKSEGVE FTVKDGHLCP ALAKAVKTMK KGEKVLLAVK PQYGFGEMGR 

       250        260        270        280        290        300 
PAAGEGGAVP PNASLVIDLE LVSWKTVTEI GDDKKILKKV LKEXEGYERP NEGAVVTVKI 

       310        320        330        340        350        360 
TGKLQDGTVF LKKGHDEQEP FEFKTDEEAV IEGLDRAVLN MKKGEVALVT IPPEYAYGST 

       370        380        390        400        410        420 
ESKQDAIVPP NSTVIYEVEL VSFVKDKESW DLNNSEKIEA AGTKKEEGNA LFKSGKYARA 

       430        440        450        460        470        480 
SKRYEKAAKF IEYDTSFSED EKKQSKQLKI TCNLNNAACK LKLKDYKQAE KLCTKVLELD 

       490        500        510        520        530        540 
SRNVKALYRR AQAYTQLADL ELAEVDIKKA LEIDPENRDV KLTYKTLKEK IKEINKKDAK 

       550 
FYSNMFSKMT KPSAEESKA 

« Hide

References

[1]"Wheat FKBP70 - a novel heat shock and calmodulin binding PPIase."
Oshra B., Breiman A.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Atir.
Tissue: Root tip.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X86903 mRNA. Translation: CAA60505.1.
PIRS55383.
UniGeneTa.55812.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3JXVX-ray2.08A31-386[»]
3JYMX-ray2.28A/B15-391[»]
ProteinModelPortalQ43207.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneQ43207.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 3 hits.
PF00515. TPR_1. 2 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 3 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ43207.

Entry information

Entry nameFKB70_WHEAT
AccessionPrimary (citable) accession number: Q43207
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references