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Q43207

- FKB70_WHEAT

UniProt

Q43207 - FKB70_WHEAT

Protein

70 kDa peptidyl-prolyl isomerase

Gene

FKBP70

Organism
Triticum aestivum (Wheat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    70 kDa peptidyl-prolyl isomerase (EC:5.2.1.8)
    Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
    Short name:
    PPIase
    Rotamase
    Gene namesi
    Name:FKBP70
    OrganismiTriticum aestivum (Wheat)
    Taxonomic identifieri4565 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum
    ProteomesiUP000019116: Unplaced

    Organism-specific databases

    GrameneiQ43207.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 55955970 kDa peptidyl-prolyl isomerasePRO_0000075335Add
    BLAST

    Expressioni

    Inductioni

    By heat shock.

    Interactioni

    Subunit structurei

    This PPIase probably binds calmodulin.

    Structurei

    Secondary structure

    1
    559
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 363
    Beta strandi62 – 665
    Turni91 – 944
    Helixi100 – 1067
    Beta strandi112 – 1165
    Beta strandi139 – 14810
    Beta strandi150 – 1523
    Beta strandi155 – 16511
    Beta strandi168 – 1703
    Beta strandi178 – 18710
    Beta strandi192 – 20211
    Helixi203 – 2053
    Beta strandi207 – 2093
    Helixi210 – 2167
    Beta strandi224 – 2296
    Helixi231 – 2333
    Turni234 – 2385
    Beta strandi255 – 26511
    Beta strandi267 – 2715
    Beta strandi276 – 2827
    Beta strandi285 – 2873
    Beta strandi295 – 30713
    Beta strandi309 – 3146
    Beta strandi322 – 3243
    Turni325 – 3284
    Helixi332 – 3387
    Beta strandi346 – 3516
    Helixi353 – 3553
    Turni356 – 3594
    Beta strandi362 – 3687
    Beta strandi374 – 38411

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3JXVX-ray2.08A31-386[»]
    3JYMX-ray2.28A/B15-391[»]
    ProteinModelPortaliQ43207.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ43207.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 14889PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini176 – 26590PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini293 – 38492PPIase FKBP-type 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati401 – 43434TPR 1Add
    BLAST
    Repeati450 – 48334TPR 2Add
    BLAST
    Repeati484 – 51734TPR 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 PPIase FKBP-type domains.PROSITE-ProRule annotation
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 3 hits.
    PF00515. TPR_1. 2 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 3 hits.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q43207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDDFDIPAG DDMMMGDGMG DFGGAEGPGM KVGEENEIGK QGLKKKLLKE    50
    GEGWDTPEVG DEVEVHYTGT LLDGKKFDSS RDRDDTFKFK LGQGQVIKGW 100
    DQGIKTMKKG ENALFTIPPE LAYGESGSPP TIPANATLQF DVELLSWTSV 150
    RDIAKDGGIF KKILKEGDKW ENPKDPDEVF VKYEARLEDG TVVSKSEGVE 200
    FTVKDGHLCP ALAKAVKTMK KGEKVLLAVK PQYGFGEMGR PAAGEGGAVP 250
    PNASLVIDLE LVSWKTVTEI GDDKKILKKV LKEXEGYERP NEGAVVTVKI 300
    TGKLQDGTVF LKKGHDEQEP FEFKTDEEAV IEGLDRAVLN MKKGEVALVT 350
    IPPEYAYGST ESKQDAIVPP NSTVIYEVEL VSFVKDKESW DLNNSEKIEA 400
    AGTKKEEGNA LFKSGKYARA SKRYEKAAKF IEYDTSFSED EKKQSKQLKI 450
    TCNLNNAACK LKLKDYKQAE KLCTKVLELD SRNVKALYRR AQAYTQLADL 500
    ELAEVDIKKA LEIDPENRDV KLTYKTLKEK IKEINKKDAK FYSNMFSKMT 550
    KPSAEESKA 559
    Length:559
    Mass (Da):62,058
    Last modified:November 1, 1996 - v1
    Checksum:i5C5DAE70D716B541
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86903 mRNA. Translation: CAA60505.1.
    PIRiS55383.
    UniGeneiTa.55812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86903 mRNA. Translation: CAA60505.1 .
    PIRi S55383.
    UniGenei Ta.55812.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3JXV X-ray 2.08 A 31-386 [» ]
    3JYM X-ray 2.28 A/B 15-391 [» ]
    ProteinModelPortali Q43207.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q43207.

    Miscellaneous databases

    EvolutionaryTracei Q43207.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 3 hits.
    PF00515. TPR_1. 2 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 3 hits.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Wheat FKBP70 - a novel heat shock and calmodulin binding PPIase."
      Oshra B., Breiman A.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Atir.
      Tissue: Root tip.

    Entry informationi

    Entry nameiFKB70_WHEAT
    AccessioniPrimary (citable) accession number: Q43207
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3