Q43207 (FKB70_WHEAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
70 kDa peptidyl-prolyl isomerase
EC=5.2.1.8

Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase

Gene names

Name:

FKBP70

Organism

Triticum aestivum (Wheat)

Taxonomic identifier

4565 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Pooideae › Triticeae › Triticum

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins during protein synthesis.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	This PPIase probably binds calmodulin.
Induction	By heat shock.
Sequence similarities	Contains 3 PPIase FKBP-type domains. Contains 3 TPR repeats.

Ontologies

Keywords
Biological process	Stress response
Domain	Repeat TPR repeat
Ligand	Calmodulin-binding
Molecular function	Isomerase Rotamase
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 559

559

70 kDa peptidyl-prolyl isomerase

PRO_0000075335

Regions

Domain

60 – 148

89

PPIase FKBP-type 1

Domain

176 – 265

90

PPIase FKBP-type 2

Domain

293 – 384

92

PPIase FKBP-type 3

Repeat

401 – 434

34

TPR 1

Repeat

450 – 483

34

TPR 2

Repeat

484 – 517

34

TPR 3

Secondary structure

1

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559

Helix Strand Turn

Details...

Beta strand

34 – 36

3

Beta strand

62 – 66

5

Turn

91 – 94

4

Helix

100 – 106

7

Beta strand

112 – 116

5

Beta strand

139 – 148

10

Beta strand

150 – 152

3

Beta strand

155 – 165

11

Beta strand

168 – 170

3

Beta strand

178 – 187

10

Beta strand

192 – 202

11

Helix

203 – 205

3

Beta strand

207 – 209

3

Helix

210 – 216

7

Beta strand

224 – 229

6

Helix

231 – 233

3

Turn

234 – 238

5

Beta strand

255 – 265

11

Beta strand

267 – 271

5

Beta strand

276 – 282

7

Beta strand

285 – 287

3

Beta strand

295 – 307

13

Beta strand

309 – 314

6

Beta strand

322 – 324

3

Turn

325 – 328

4

Helix

332 – 338

7

Beta strand

346 – 351

6

Helix

353 – 355

3

Turn

356 – 359

4

Beta strand

362 – 368

7

Beta strand

374 – 384

11

Sequences

	Sequence		Length	Mass (Da)
	Q43207 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5C5DAE70D716B541	FASTA	559	62,058
	10 20 30 40 50 60 MDDDFDIPAG DDMMMGDGMG DFGGAEGPGM KVGEENEIGK QGLKKKLLKE GEGWDTPEVG 70 80 90 100 110 120 DEVEVHYTGT LLDGKKFDSS RDRDDTFKFK LGQGQVIKGW DQGIKTMKKG ENALFTIPPE 130 140 150 160 170 180 LAYGESGSPP TIPANATLQF DVELLSWTSV RDIAKDGGIF KKILKEGDKW ENPKDPDEVF 190 200 210 220 230 240 VKYEARLEDG TVVSKSEGVE FTVKDGHLCP ALAKAVKTMK KGEKVLLAVK PQYGFGEMGR 250 260 270 280 290 300 PAAGEGGAVP PNASLVIDLE LVSWKTVTEI GDDKKILKKV LKEXEGYERP NEGAVVTVKI 310 320 330 340 350 360 TGKLQDGTVF LKKGHDEQEP FEFKTDEEAV IEGLDRAVLN MKKGEVALVT IPPEYAYGST 370 380 390 400 410 420 ESKQDAIVPP NSTVIYEVEL VSFVKDKESW DLNNSEKIEA AGTKKEEGNA LFKSGKYARA 430 440 450 460 470 480 SKRYEKAAKF IEYDTSFSED EKKQSKQLKI TCNLNNAACK LKLKDYKQAE KLCTKVLELD 490 500 510 520 530 540 SRNVKALYRR AQAYTQLADL ELAEVDIKKA LEIDPENRDV KLTYKTLKEK IKEINKKDAK 550 FYSNMFSKMT KPSAEESKA

References

[1]	"Wheat FKBP70 - a novel heat shock and calmodulin binding PPIase." Oshra B., Breiman A. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Atir. Tissue: Root tip.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X86903 mRNA. Translation: CAA60505.1.

PIR

S55383.

UniGene

Ta.55812.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3JXV	X-ray	2.08	A	31-386	[»]
3JYM	X-ray	2.28	A/B	15-391	[»]

ProteinModelPortal

Q43207.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

Gramene

Q43207.

Family and domain databases

Gene3D

1.25.40.10. 1 hit.

InterPro

IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR001440. TPR-1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]

PANTHER

PTHR10516. PTHR10516. 1 hit.

Pfam

PF00254. FKBP_C. 3 hits.
PF00515. TPR_1. 2 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]

SMART

SM00028. TPR. 3 hits.
[Graphical view]

PROSITE

PS50059. FKBP_PPIASE. 3 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q43207.

Entry information

Entry name

FKB70_WHEAT

Accession

Primary (citable) accession number: Q43207

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	March 6, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program