Reviewed, UniProtKB/Swiss-Prot Q43199 (APT1_WHEAT)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase 1
      Short name=APRT 1
    EC=2.4.2.7

Gene names

Name:

APT1

Organism

Triticum aestivum (Wheat)

Taxonomic identifier

4565 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Pooideae › Triticeae › Triticum

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Adenine phosphoribosyltransferase 1		PRO_0000149516

Sequences

	Sequence		Length	Mass (Da)
	Q43199-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 3325FBCF3780B24C	FASTA	181	19,664
	10 20 30 40 50 60 MASDGRVERI ASSIRAIPNF PKPGILFQDI TTLLLDPQAF RDTTDLFVER YKDKDITVVA 70 80 90 100 110 120 GVEARGFIFG PPIALAIGAK FVPIRKPKKL PGEVISEEYS LEYGTDKIEM HVGAVQPNDR 130 140 150 160 170 180 VLIVDDLIAT GGTLCAAAKL IERVGAKVVE CACVIELPEL KGRDKLGDMP VFVLVQADES V

References

[1]	"Nucleotide sequence of a wheat cDNA encoding adenine phosphoribosyltransferase." Moffatt B.A., Schnorr K.S., Gaillard C., Biget E., Laloue M. Plant Gene Register PGR95-030 Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Capitole. Tissue: Seed.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U22442 mRNA. Translation: AAA80609.1.
PIR	T06263.
UniGene	Ta.43
3D structure databases
HSSP	HSSP built from PDB template 1G2Q based on UniProtKB P49435.
ModBase	Search...
Organism-specific databases
Gramene	Q43199.
Enzyme and pathway databases
BRENDA	2.4.2.7. 253.
Family and domain databases
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT1_WHEAT

Accession

Primary (citable) accession number: Q43199

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)