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Protein

Probable linoleate 9S-lipoxygenase 5

Gene

LOX1.5

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. May contribute to cell death during the hypersensitive response (HR) by the massive production of free fatty acid hydroperoxides. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.

Catalytic activityi

Linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi: oxylipin biosynthesis

This protein is involved in the pathway oxylipin biosynthesis, which is part of Lipid metabolism.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway oxylipin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi523Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi528Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi714Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi718Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi862Iron; via carboxylate; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382

Names & Taxonomyi

Protein namesi
Recommended name:
Probable linoleate 9S-lipoxygenase 5 (EC:1.13.11.58)
Alternative name(s):
Leaf lipoxygenase
Gene namesi
Name:LOX1.5
Synonyms:POTLX-3
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2189149

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004129231 – 862Probable linoleate 9S-lipoxygenase 5Add BLAST862

Expressioni

Tissue specificityi

Not detected in leaves, stems, flowers, roots, tubers and stolons during normal growth and development.1 Publication

Inductioni

Up-regulated within 6 hours after pathogen infection, ethylene or jasmonate treatments. Not induced by wounding.1 Publication

Gene expression databases

ExpressionAtlasiQ43191 baseline and differential

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi4113.PGSC0003DMT400028158

Chemistry databases

BindingDBiQ43191

Structurei

3D structure databases

ProteinModelPortaliQ43191
SMRiQ43191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 161PLATPROSITE-ProRule annotationAdd BLAST126
Domaini164 – 862LipoxygenasePROSITE-ProRule annotationAdd BLAST699

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Phylogenomic databases

eggNOGiENOG410IH0D Eukaryota
ENOG410YN4N LUCA
InParanoidiQ43191
KOiK15718

Family and domain databases

Gene3Di4.10.372.10, 1 hit
InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001246 LipOase_plant
IPR027433 Lipoxygenase_dom_3
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00468 PLTLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q43191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLEKIVEAI SGRSEDNGKK VKGTIVLMKK NVLDFNDVNA SLLDGVLEFL
60 70 80 90 100
GKRVSLQLIS VVHADPGNSL QGKRSNPAYL EKWLTTGTSL VAGESAFDVT
110 120 130 140 150
FDWDEDIGVP GAFIINNFHF NEFYLKSLTL EDVPNHGNVH FVCNSWVYPA
160 170 180 190 200
KKYKSERIFF ANQAYLPGET PEPLRNYREK ELVNLRGNGN GKLEEWDRVY
210 220 230 240 250
DYALYNDLGD PEKGKQYART ILGGSAEYPY PRRGRTGRKP TKADPKSESR
260 270 280 290 300
IPLLMSLDIY VPRDERFGHI KLSDFLTYAL KSIVQFLIPE FQALFDSTPD
310 320 330 340 350
EFDSFEDVLK LYEGGIKLPQ GPFLKALTDS IPLEILKEII RTDGEGKFKF
360 370 380 390 400
PTPQVIQEDK SSWRTDEEFA REMLAGVNPV IISRLQEFPP KSQLDSEVYG
410 420 430 440 450
NQNSTITKEH IENTLDGLTI DDAIKTNRLY ILNHHDILMP YVRRINTTNT
460 470 480 490 500
KLYASRTLLF LQDDGTMKPV AIELSLPHPD GDELGAVSKV YTPADQGVEG
510 520 530 540 550
SIWQLAKAYV AVNDSGVHQL ISHWLNTHAA IEPFVIATNR QLSVLHPIHK
560 570 580 590 600
LLHPHFRDTM NINALARQIL INAGGVLEMT VFPAKYAMEM SAVVYKSWVF
610 620 630 640 650
PEQALPADLI KRGVAVEDSS SPHGVRLLIQ DYPYAVDGLE IWSAIKSWVT
660 670 680 690 700
EYCNFYYKSD ELVLKDNELQ AWWKELREEG HGDKKDEPWW PKMQTRQELK
710 720 730 740 750
DSCTIIIWIA SALHAAVNFG QYPYAGYLPN RPTLSRRFMP EPGTPEYEEL
760 770 780 790 800
KTNPDKAYLK TITPQLQTLL GISLIEILSR HASDEIYLGQ RDSSEWTKDQ
810 820 830 840 850
EPIAAFERFG KKLSEIEDQI IQMNGDKKWK NRSGPVNVPY TLLFPTSEQG
860
LTGKGIPNSV SI
Length:862
Mass (Da):97,778
Last modified:November 1, 1996 - v1
Checksum:i94667A9F56041E89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60202 mRNA Translation: AAB67865.1
PIRiT07775
RefSeqiNP_001274916.1, NM_001287987.1
UniGeneiStu.18586

Genome annotation databases

GeneIDi102577714
KEGGisot:102577714

Similar proteinsi

Entry informationi

Entry nameiLOX15_SOLTU
AccessioniPrimary (citable) accession number: Q43191
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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