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Protein

Probable linoleate 9S-lipoxygenase 4

Gene

LOX1.4

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.PROSITE-ProRule annotation

Catalytic activityi

Linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi: oxylipin biosynthesis

This protein is involved in the pathway oxylipin biosynthesis, which is part of Lipid metabolism.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway oxylipin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi521Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi526Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi712Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi716Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi860Iron; via carboxylate; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382

Names & Taxonomyi

Protein namesi
Recommended name:
Probable linoleate 9S-lipoxygenase 4 (EC:1.13.11.58)
Alternative name(s):
Root lipoxygenase
Gene namesi
Name:LOX1.4
Synonyms:POTLX-2
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004129221 – 860Probable linoleate 9S-lipoxygenase 4Add BLAST860

Proteomic databases

PRIDEiQ43190

Expressioni

Tissue specificityi

Expressed in tubers and roots. Not detected in leaves, flowers, stems, shoot tips, or axillary buds.2 Publications

Gene expression databases

ExpressionAtlasiQ43190 baseline and differential

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ43190
SMRiQ43190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 159PLATPROSITE-ProRule annotationAdd BLAST131
Domaini162 – 860LipoxygenasePROSITE-ProRule annotationAdd BLAST699

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi445 – 450Poly-Thr6

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Phylogenomic databases

eggNOGiENOG410IH0D Eukaryota
ENOG410YN4N LUCA
InParanoidiQ43190
KOiK15718

Family and domain databases

Gene3Di4.10.372.10, 1 hit
InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001246 LipOase_plant
IPR027433 Lipoxygenase_dom_3
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00468 PLTLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q43190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQIVGGLI GGHHDSKKVK GTVVMMKKNA LDFTDLAGSL TDKIFEALGQ
60 70 80 90 100
KVSFQLISSV QSDPANGLQG KHSNPAYLEN FLFTLTPLAA GETAFGVTFD
110 120 130 140 150
WNEEFGVPGA FIIKNTHINE FFLKSLTLED VPNHGKVHFV CNSWVYPSFR
160 170 180 190 200
YKSDRIFFAN QPYLPSETPE LLRKYRENEL LTLRGDGTGK REAWDRIYDY
210 220 230 240 250
DVYNDLGNPD QGKENVRTTL GGSADYPYPR RGRTGRPPTR TDPKSESRIP
260 270 280 290 300
LILSLDIYVP RDERFGHLKM SDFLTYALKS IVQFILPELH ALFDGTPNEF
310 320 330 340 350
DSFEDVLRLY EGGIRLPQGP LFKALTDAIP LEMIRELLRT DGEGILRFPT
360 370 380 390 400
PLVIKDSKTA WRTDEEFARE MLAGVNPIII SRLQEFPPKS KLDPEAYGNQ
410 420 430 440 450
NSTITAEHIE DKLDGLTVDE AMNNNKLFIL NHHDVLIPYL RRINTTTTKT
460 470 480 490 500
YASRTLLFLQ DNGSLKPLAI ELSLPHPDGD QFGVTSKVYT PSDQGVESSI
510 520 530 540 550
WQLAKAYVAV NDSGVHQLIS HWLNTHAVIE PFVIATNRQL SVLHPIHKLL
560 570 580 590 600
YPHFRDTMNI NAMARQILIN AGGVLESTVF PSKFAMEMSA VVYKDWVFPD
610 620 630 640 650
QALPADLVKR GVAVEDSSSP HGVRLLIEDY PYAVDGLEIW SAIKSWVTDY
660 670 680 690 700
CSFYYGSDEE ILKDNELQAW WKELREVGHG DKKNEPWWPE METPQELIDS
710 720 730 740 750
CTTIIWIASA LHAAVNFGQY PYAGYLPNRP TVSRRFMPEP GTPEYEELKK
760 770 780 790 800
NPDKAFLKTI TAQLQTLLGV SLIEILSRHT TDEIYLGQRE SPEWTKDKEP
810 820 830 840 850
LAAFDKFGKK LTDIEKQIIQ RNGDNILINR SGPVNAPYTL LFPTSEGGLT
860
GKGIPNSVSI
Length:860
Mass (Da):96,969
Last modified:November 1, 1996 - v1
Checksum:i11FD0D769921053E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60201 mRNA Translation: AAB67860.1
RefSeqiNP_001305607.1, NM_001318678.1
UniGeneiStu.965

Genome annotation databases

GeneIDi102602528
KEGGisot:102602528

Similar proteinsi

Entry informationi

Entry nameiLOX14_SOLTU
AccessioniPrimary (citable) accession number: Q43190
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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