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Q43188 (CHS2_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 2

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 2
Gene names
Name:CHS2
OrganismSolanum tuberosum (Potato) [Reference proteome]
Taxonomic identifier4113 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Chalcone synthase 2
PRO_0000216054

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q43188 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 41618F9944958603

FASTA38942,476
        10         20         30         40         50         60 
MVTVEEVRKA QRAKGPATIM AIGTATPSNC VDQSTYPDYY FRITNSEHMT ELKEKFKRMC 

        70         80         90        100        110        120 
DKSMINKRYM HLTEEILKEN PNICEYMAPS LDARQDIVVV EVPKLGKEAA QKAIKEWGQP 

       130        140        150        160        170        180 
KSKITHVVFC TTSGVDMPGA DYQLTKLLGL RPSVKRLMMY QQGCFAGGTV IRLAKDLAEN 

       190        200        210        220        230        240 
NKGARVLVVC SEITAVTFSG PSDTHLDSMV GQALFGDGAA AMIIGSDPLP EVERPLFELV 

       250        260        270        280        290        300 
SAAQTLLPDS EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLIEAFQPL GISDWNSIFW 

       310        320        330        340        350        360 
IAHPGGPAIL DQVELKLGLK PEKLQATRQV LSDYGNMSSA CVLFILDEMR KASSKEGLST 

       370        380 
TGEGLDWGVL FGFGPGLTVE TVVLHSVST 

« Hide

References

[1]"Cloning and characterization of one member of the chalcone synthase gene family from Solanum tuberosum L."
Jeon J.-H., Kim H.S., Choi K.H., Joung Y.H., Joung H., Byun S.-M.
Biosci. Biotechnol. Biochem. 60:1907-1910(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Red Pontiac.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U47738 mRNA. Translation: AAB05239.1.
PIRJC5136.
RefSeqNP_001275296.1. NM_001288367.1.
UniGeneStu.18497.

3D structure databases

ProteinModelPortalQ43188.
SMRQ43188. Positions 3-388.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102577598.

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS2_SOLTU
AccessionPrimary (citable) accession number: Q43188
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways