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Protein

Chalcone synthase 2

Gene

CHS2

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 2 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 2
Gene namesi
Name:CHS2
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Chalcone synthase 2PRO_0000216054Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ43188.
SMRiQ43188. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

InParanoidiQ43188.
KOiK00660.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q43188-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTVEEVRKA QRAKGPATIM AIGTATPSNC VDQSTYPDYY FRITNSEHMT
60 70 80 90 100
ELKEKFKRMC DKSMINKRYM HLTEEILKEN PNICEYMAPS LDARQDIVVV
110 120 130 140 150
EVPKLGKEAA QKAIKEWGQP KSKITHVVFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPSVKRLMMY QQGCFAGGTV IRLAKDLAEN NKGARVLVVC SEITAVTFSG
210 220 230 240 250
PSDTHLDSMV GQALFGDGAA AMIIGSDPLP EVERPLFELV SAAQTLLPDS
260 270 280 290 300
EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLIEAFQPL GISDWNSIFW
310 320 330 340 350
IAHPGGPAIL DQVELKLGLK PEKLQATRQV LSDYGNMSSA CVLFILDEMR
360 370 380
KASSKEGLST TGEGLDWGVL FGFGPGLTVE TVVLHSVST
Length:389
Mass (Da):42,476
Last modified:November 1, 1996 - v1
Checksum:i41618F9944958603
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47738 mRNA. Translation: AAB05239.1.
PIRiJC5136.
RefSeqiNP_001275296.1. NM_001288367.1.
UniGeneiStu.18497.

Genome annotation databases

GeneIDi102577598.
KEGGisot:102577598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47738 mRNA. Translation: AAB05239.1.
PIRiJC5136.
RefSeqiNP_001275296.1. NM_001288367.1.
UniGeneiStu.18497.

3D structure databases

ProteinModelPortaliQ43188.
SMRiQ43188. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102577598.
KEGGisot:102577598.

Phylogenomic databases

InParanoidiQ43188.
KOiK00660.

Enzyme and pathway databases

UniPathwayiUPA00154.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of one member of the chalcone synthase gene family from Solanum tuberosum L."
    Jeon J.-H., Kim H.S., Choi K.H., Joung Y.H., Joung H., Byun S.-M.
    Biosci. Biotechnol. Biochem. 60:1907-1910(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Red Pontiac.

Entry informationi

Entry nameiCHS2_SOLTU
AccessioniPrimary (citable) accession number: Q43188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.