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Protein

Chalcone synthase 2

Gene

CHS2

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 2 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 2
Gene namesi
Name:CHS2
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002160541 – 389Chalcone synthase 2Add BLAST389

Proteomic databases

PRIDEiQ43188.

Interactioni

Protein-protein interaction databases

STRINGi4113.PGSC0003DMT400049165.

Structurei

3D structure databases

ProteinModelPortaliQ43188.
SMRiQ43188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiENOG410IKG2. Eukaryota.
COG3424. LUCA.
InParanoidiQ43188.
KOiK00660.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
PfamiView protein in Pfam
PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiView protein in PROSITE
PS00441. CHALCONE_SYNTH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q43188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVEEVRKA QRAKGPATIM AIGTATPSNC VDQSTYPDYY FRITNSEHMT
60 70 80 90 100
ELKEKFKRMC DKSMINKRYM HLTEEILKEN PNICEYMAPS LDARQDIVVV
110 120 130 140 150
EVPKLGKEAA QKAIKEWGQP KSKITHVVFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPSVKRLMMY QQGCFAGGTV IRLAKDLAEN NKGARVLVVC SEITAVTFSG
210 220 230 240 250
PSDTHLDSMV GQALFGDGAA AMIIGSDPLP EVERPLFELV SAAQTLLPDS
260 270 280 290 300
EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLIEAFQPL GISDWNSIFW
310 320 330 340 350
IAHPGGPAIL DQVELKLGLK PEKLQATRQV LSDYGNMSSA CVLFILDEMR
360 370 380
KASSKEGLST TGEGLDWGVL FGFGPGLTVE TVVLHSVST
Length:389
Mass (Da):42,476
Last modified:November 1, 1996 - v1
Checksum:i41618F9944958603
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47738 mRNA. Translation: AAB05239.1.
PIRiJC5136.
RefSeqiNP_001275296.1. NM_001288367.1.
UniGeneiStu.18497.

Genome annotation databases

GeneIDi102577598.
KEGGisot:102577598.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCHS2_SOLTU
AccessioniPrimary (citable) accession number: Q43188
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 15, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families