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Protein

Chalcone synthase 1B

Gene

CHS1B

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1B (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1B
Gene namesi
Name:CHS1B
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Chalcone synthase 1BPRO_0000216053Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ43163.
SMRiQ43163. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

InParanoidiQ43163.
OMAiDYMICER.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q43163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVEEYRKA QRAEGPATIL AIGTSTPSNC VDQSTYPDYY FRITNSEHKT
60 70 80 90 100
ELKEKFKRMC DKSMIKKRYM HLTEEILKEN PNMCAYMAPS LDARQDIVVV
110 120 130 140 150
EVPKLGKEAA QKAIKEWGQP KSKITHLVFC TTSGVDMPGC DYQLAKLLGL
160 170 180 190 200
RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG
210 220 230 240 250
PSESHLDSLV GQALFGDGAA AIIMGSDPII GVERPLFELV SAAQTLVPDS
260 270 280 290 300
EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLLEAFQPL GISDWNSLFW
310 320 330 340 350
IAHPGGPAIL DQVELKLGLK QEKLRATREV LSNYGNMSSA CVLFILDEMR
360 370 380
KASTKEGLGT TGEGLEWGVL FGFGPGLTVE TVVLHSVAT
Length:389
Mass (Da):42,548
Last modified:October 31, 1996 - v1
Checksum:iE7334A1A34D8D1CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47740 mRNA. Translation: AAB67735.1.

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400076178; PGSC0003DMT400076178; PGSC0003DMG400029620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47740 mRNA. Translation: AAB67735.1.

3D structure databases

ProteinModelPortaliQ43163.
SMRiQ43163. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400076178; PGSC0003DMT400076178; PGSC0003DMG400029620.

Phylogenomic databases

InParanoidiQ43163.
OMAiDYMICER.

Enzyme and pathway databases

UniPathwayiUPA00154.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two members of the chalcone synthase gene family from Solanum tuberosum L."
    Jeon J.-H., Kim H.-S., Choi K.-H., Joung Y.-H., Joung H., Byun S.-M.
    Plant Gene Register PGR96-027
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Red Pontiac.
  2. "Genome sequence and analysis of the tuber crop potato."
    The Potato Genome Sequencing Consortium
    Nature 475:189-195(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. DM1-3 516 R44.

Entry informationi

Entry nameiCHSB_SOLTU
AccessioniPrimary (citable) accession number: Q43163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1999
Last sequence update: October 31, 1996
Last modified: January 6, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.