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Protein

ATPase 10, plasma membrane-type

Gene

AHA10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei337 – 33714-aspartylphosphate intermediateBy similarity
Metal bindingi595 – 5951MagnesiumBy similarity
Metal bindingi599 – 5991MagnesiumBy similarity

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Source: TAIR
  • ATP binding Source: UniProtKB-KW
  • cation-transporting ATPase activity Source: TAIR
  • hydrogen-exporting ATPase activity, phosphorylative mechanism Source: TAIR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • ATP biosynthetic process Source: InterPro
  • proanthocyanidin biosynthetic process Source: TAIR
  • seed coat development Source: TAIR
  • vacuolar acidification Source: TAIR
  • vacuole organization Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G17260-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase 10, plasma membrane-type (EC:3.6.3.6)
Alternative name(s):
Proton pump 10
Gene namesi
Name:AHA10
Ordered Locus Names:At1g17260
ORF Names:F20D23.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G17260.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 8920Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini90 – 10112ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini123 – 251129CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini273 – 2819ExtracellularSequence analysis
Transmembranei282 – 29918Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini300 – 650351CytoplasmicSequence analysisAdd
BLAST
Transmembranei651 – 67222Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini673 – 6775ExtracellularSequence analysis
Transmembranei678 – 70023Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini701 – 71616CytoplasmicSequence analysisAdd
BLAST
Transmembranei717 – 73721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini738 – 75821ExtracellularSequence analysisAdd
BLAST
Transmembranei759 – 77921Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini780 – 79112CytoplasmicSequence analysisAdd
BLAST
Transmembranei792 – 81221Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini813 – 8208ExtracellularSequence analysis
Transmembranei821 – 84121Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini842 – 947106CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • chloroplast Source: TAIR
  • integral component of plasma membrane Source: GO_Central
  • plant-type vacuole membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 947947ATPase 10, plasma membrane-typePRO_0000046283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei897 – 8971PhosphoserineBy similarity
Modified residuei929 – 9291PhosphoserineBy similarity
Modified residuei946 – 9461PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ43128.
PRIDEiQ43128.

PTM databases

iPTMnetiQ43128.

Expressioni

Tissue specificityi

Found primarily in developing seeds.

Gene expression databases

GenevisibleiQ43128. AT.

Interactioni

Protein-protein interaction databases

BioGridi23537. 8 interactions.
MINTiMINT-8067533.
STRINGi3702.AT1G17260.1.

Structurei

3D structure databases

ProteinModelPortaliQ43128.
SMRiQ43128. Positions 20-850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000160005.
InParanoidiQ43128.
KOiK01535.
OMAiAYQEIPE.
OrthoDBiEOG0936026Q.
PhylomeDBiQ43128.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q43128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDLDKPLL DPDTFNRKGI DLGILPLEEV FEYLRTSPQG LLSGDAEERL
60 70 80 90 100
KIFGPNRLEE KQENRFVKFL GFMWNPLSWV MEAAALMAIA LANSQSLGPD
110 120 130 140 150
WEDFTGIVCL LLINATISFF EENNAGNAAA ALMARLALKT RVLRDGQWQE
160 170 180 190 200
QDASILVPGD IISIKLGDII PADARLLEGD PLKIDQSVLT GESLPVTKKK
210 220 230 240 250
GEQVFSGSTC KQGEIEAVVI ATGSTTFFGK TARLVDSTDV TGHFQQVLTS
260 270 280 290 300
IGNFCICSIA VGMVLEIIIM FPVQHRSYRI GINNLLVLLI GGIPIAMPTV
310 320 330 340 350
LSVTLAIGSH RLSQQGAITK RMTAIEEMAG MDVLCCDKTG TLTLNSLTVD
360 370 380 390 400
KNLIEVFVDY MDKDTILLLA GRASRLENQD AIDAAIVSML ADPREARANI
410 420 430 440 450
REIHFLPFNP VDKRTAITYI DSDGKWYRAT KGAPEQVLNL CQQKNEIAQR
460 470 480 490 500
VYAIIDRFAE KGLRSLAVAY QEIPEKSNNS PGGPWRFCGL LPLFDPPRHD
510 520 530 540 550
SGETILRALS LGVCVKMITG DQLAIAKETG RRLGMGTNMY PSSSLLGHNN
560 570 580 590 600
DEHEAIPVDE LIEMADGFAG VFPEHKYEIV KILQEMKHVV GMTGDGVNDA
610 620 630 640 650
PALKKADIGI AVADATDAAR SSADIVLTDP GLSVIISAVL TSRAIFQRMR
660 670 680 690 700
NYTVYAVSIT IRIVLGFTLL ALIWEYDFPP FMVLIIAILN DGTIMTISKD
710 720 730 740 750
RVRPSPTPES WKLNQIFATG IVIGTYLALV TVLFYWIIVS TTFFEKHFHV
760 770 780 790 800
KSIANNSEQV SSAMYLQVSI ISQALIFVTR SRGWSFFERP GTLLIFAFIL
810 820 830 840 850
AQLAATLIAV YANISFAKIT GIGWRWAGVI WLYSLIFYIP LDVIKFVFHY
860 870 880 890 900
ALSGEAWNLV LDRKTAFTYK KDYGKDDGSP NVTISQRSRS AEELRGSRSR
910 920 930 940
ASWIAEQTRR RAEIARLLEV HSVSRHLESV IKLKQIDQRM IRAAHTV
Length:947
Mass (Da):104,815
Last modified:January 24, 2001 - v2
Checksum:i1E951DFCC0DA5C24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74033 Genomic DNA. Translation: AAB32310.2.
AC007651 Genomic DNA. Translation: AAD50009.3.
CP002684 Genomic DNA. Translation: AEE29565.1.
PIRiS66367.
RefSeqiNP_173169.2. NM_101587.2.
UniGeneiAt.51646.

Genome annotation databases

EnsemblPlantsiAT1G17260.1; AT1G17260.1; AT1G17260.
GeneIDi838297.
GrameneiAT1G17260.1; AT1G17260.1; AT1G17260.
KEGGiath:AT1G17260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74033 Genomic DNA. Translation: AAB32310.2.
AC007651 Genomic DNA. Translation: AAD50009.3.
CP002684 Genomic DNA. Translation: AEE29565.1.
PIRiS66367.
RefSeqiNP_173169.2. NM_101587.2.
UniGeneiAt.51646.

3D structure databases

ProteinModelPortaliQ43128.
SMRiQ43128. Positions 20-850.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23537. 8 interactions.
MINTiMINT-8067533.
STRINGi3702.AT1G17260.1.

PTM databases

iPTMnetiQ43128.

Proteomic databases

PaxDbiQ43128.
PRIDEiQ43128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17260.1; AT1G17260.1; AT1G17260.
GeneIDi838297.
GrameneiAT1G17260.1; AT1G17260.1; AT1G17260.
KEGGiath:AT1G17260.

Organism-specific databases

TAIRiAT1G17260.

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000160005.
InParanoidiQ43128.
KOiK01535.
OMAiAYQEIPE.
OrthoDBiEOG0936026Q.
PhylomeDBiQ43128.

Enzyme and pathway databases

BioCyciARA:AT1G17260-MONOMER.

Miscellaneous databases

PROiQ43128.

Gene expression databases

GenevisibleiQ43128. AT.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMA10_ARATH
AccessioniPrimary (citable) accession number: Q43128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 24, 2001
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.