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Q43116

- PDI_RICCO

UniProt

Q43116 - PDI_RICCO

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Protein

Protein disulfide-isomerase

Gene
N/A
Organism
Ricinus communis (Castor bean)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer By similarity.

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Nucleophile By similarity
Sitei62 – 621Contributes to redox potential value By similarity
Sitei63 – 631Contributes to redox potential value By similarity
Active sitei64 – 641Nucleophile By similarity
Sitei129 – 1291Lowers pKa of C-terminal Cys of first active site By similarity
Active sitei406 – 4061Nucleophile By similarity
Sitei407 – 4071Contributes to redox potential value By similarity
Sitei408 – 4081Contributes to redox potential value By similarity
Active sitei409 – 4091Nucleophile By similarity
Sitei470 – 4701Lowers pKa of C-terminal Cys of second active site By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase (EC:5.3.4.1)
Short name:
PDI
OrganismiRicinus communis (Castor bean)
Taxonomic identifieri3988 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeAcalyphoideaeAcalypheaeRicinus

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 498475Protein disulfide-isomerasePRO_0000034211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi61 ↔ 64Redox-active By similarity
Disulfide bondi406 ↔ 409Redox-active By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ43116.
ProMEXiQ43116.

Structurei

3D structure databases

ProteinModelPortaliQ43116.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 143120Thioredoxin 1Add
BLAST
Domaini339 – 484146Thioredoxin 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi495 – 4984Prevents secretion from ER By similarity

Sequence similaritiesi

Contains 2 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43116-1 [UniParc]FASTAAdd to Basket

« Hide

MASFRGSIWY CIFVLSLIAV AISAAESEEE QSSVLTLDST NFTDTISKHD    50
FIVVEFYAPW CGHCKKLRPE YEKAASILKS HDIPVVLAKV DANEEANKEL 100
ATQYDIKGFP TLKILRNGGK SIQEYKGPRE ADGIAEYLKK QSGPASVEIK 150
STEAANTFIG DKKIFIVGVF PKFSGEEYEN YMSVADKLRS DYEFGHTLDA 200
KHLPQGESSV TGPVVRLFKP FDELFVDFKD FNVDALEKFV EESSMPVVTV 250
FNSDPSNHPF VIKFFNSPDA KAMLFMNFNG EAADSIKSKY QEVAHQFKGE 300
GIILLLGDVE ASQGAFQYFG LKEDQVPLII IQTNDGQKYL KANLEPDHIA 350
PWVKAYKEGK VQAYRKSEPI PEVNNEPVKV VVADTLQDIV FNSGKNVLLE 400
FYAPWCGHCK QLAPILDEVA VSYKSDADIV IAKLDATAND IPSDTFDVRG 450
YPTVYFRSAS GKVEQYDGDR TKDDIISFIE KNRDKAAQQE SANGKDEL 498
Length:498
Mass (Da):55,561
Last modified:November 1, 1996 - v1
Checksum:iD556492D78F955D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41385 mRNA. Translation: AAB05641.1.
PIRiS62626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41385 mRNA. Translation: AAB05641.1 .
PIRi S62626.

3D structure databases

ProteinModelPortali Q43116.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q43116.
ProMEXi Q43116.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterisation of plant endoplasmic reticulum. Identification of protein disulfide-isomerase as the major reticuloplasmin."
    Coughlan S.J., Hastings C., Winfrey R.J.
    Eur. J. Biochem. 235:215-224(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Hale.

Entry informationi

Entry nameiPDI_RICCO
AccessioniPrimary (citable) accession number: Q43116
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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