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Q43097 (ACEA_PINTA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate lyase
Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL 8
OrganismPinus taeda (Loblolly pine)
Taxonomic identifier3352 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Coniferopsida › Coniferales › Pinaceae › Pinus › Pinus

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in storage lipid mobilization during the growth of higher plant seedling.

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Glyoxysome.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentGlyoxysome
Peroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentglyoxysome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580Isocitrate lyase
PRO_0000068809

Regions

Motif578 – 5803Microbody targeting signal Potential

Sites

Active site2151 Probable

Sequences

Sequence LengthMass (Da)Tools
Q43097 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E85785DAE970D697

FASTA58064,676
        10         20         30         40         50         60 
MAIYSAQAPN SILEEEARFE AEVSETQAWW NSTDLFRLTR RPYTARDVVR LRGSMRQSYA 

        70         80         90        100        110        120 
SNEMAKKLWR TLKTHQANKT ASRTFGALDP VQVSMMAKYL DSIYVSGWQC SSTHTTTNEP 

       130        140        150        160        170        180 
GPDLADYPYD TVPNKVEHLF FAQQFHDRKQ KEARMSMTRE ERSKTPYIDY LKPIIADGDT 

       190        200        210        220        230        240 
GFGGATATVK LCKLFVERGA AGVHIEDQAS VTKKCGHMAG KVLVSVGEHV NRMVAARLQF 

       250        260        270        280        290        300 
DIMGVETLLV ARTDAVAATL IQTNVDARDH QFILGATNPN LKGKPLADVL ARAMASGKSG 

       310        320        330        340        350        360 
ADLQAVEDEW MAMADLKLFS DCVVDGIKAL NVSEQEKGRR LGEWMQQTGG NTGNVLSYYQ 

       370        380        390        400        410        420 
AKELAEKLGI SNLFWDWDLP RTREGFYRFQ GSVKAAIVRG WAFGPHADII WMETSSPDMV 

       430        440        450        460        470        480 
ECRDFALGVK SKHPEIMLAY NLSPSFNWDA SRMTDEQMKN FIPEIARLGY CWQFITLAGF 

       490        500        510        520        530        540 
HADALVIDTF AKDFAQRGML AYVEKIQRQE MMNGVDTLAH QKWSGANYYD QLLKTVQGGI 

       550        560        570        580 
SATAAMAKGV TEDQFEETQS STLALESNIG AGTVLAKSRM

« Hide

References

[1]"Regulation of two loblolly pine (Pinus taeda L.) isocitrate lyase genes in megagametophytes of mature and stratified seeds and during postgerminative growth."
Mullen R.T., Gifford D.J.
Plant Mol. Biol. 33:593-604(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U39807 mRNA. Translation: AAC49687.1.
PIRT09779.

3D structure databases

ProteinModelPortalQ43097.
SMRQ43097. Positions 11-539.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_PINTA
AccessionPrimary (citable) accession number: Q43097
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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