Reviewed, UniProtKB/Swiss-Prot Q43075 (SPE1_PEA)

Names and origin

Protein names	Recommended name:     Arginine decarboxylase       Short name=ARGDC       Short name=ADC     EC=4.1.1.19
Organism	Pisum sativum (Garden pea)
Taxonomic identifier	3888 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Fabeae › Pisum

Protein attributes

Sequence length	728 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyridoxal phosphate. Magnesium.
Pathway	Amino-acid degradation; L-arginine degradation via ADC pathway; agmatine from L-arginine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Putrescine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 728	728	Arginine decarboxylase		PRO_0000149953
Regions
	Region	345 – 355	11	Substrate-binding By similarity
Amino acid modifications
	Modified residue	161	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q43075-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4193A30AEAD8EC4C	FASTA	728	78,710
	10 20 30 40 50 60 MPALTCFVDG AAALLHPPGY ALAGDFTLPL PFTFSAAATI TDDADATAVE DSNSIWSPSL 70 80 90 100 110 120 SSKLFRIDGW GFPYFGVNAA GDISVRPHGS ATMSHQEIDL LKVVKKASDP KCCGGLGLQL 130 140 150 160 170 180 PLVVRFPDVL KDRLESIHAA FDGAIQLQGY ESHYQGVYPV KCNQDRYIVE DIVEFGSSFR 190 200 210 220 230 240 FGLEAGSKPE LLLAMSCLCK GNREAFLVCN GFKDSEYISL ALIARKLALN TVIVLEQEEE 250 260 270 280 290 300 LDMVVEISNK LCIRPVIGVR AKLKTKHSGH FGATSGDKGK FGLTTIQILH VVKKLEQLDM 310 320 330 340 350 360 LDCLQLLHFH IGSQIPTTEL LADGVREASQ IYCELLRLGA QMKVLDIGGG LGIDYDGSKS 370 380 390 400 410 420 GDSDESVAYG LEEYAAAVVH AVKYVCDRKN VKHPVICSES GRAIVSHHSI LIFEASGAST 430 440 450 460 470 480 NTAPSLSSIE LQYLGEGLSE EALADYQNIS AATLRGEYEA CLLYTEQFKK RCVEEFKQGT 490 500 510 520 530 540 LGIEQLAAVD GLCDLITETI GVKDPVKKYH VNLSVFTSVP DFWGINQLFP IVPIHRLDEK 550 560 570 580 590 600 PTARGILSDL TCDSDGKIDK FIGGESSLPL HEMEGHGGGY YLGMFLGGSY EEALGGLHNL 610 620 630 640 650 660 FGGPSVVRVL QSDGPHGFAV TRAVAGSSCA DVLRVMQHEP QLMFETLKHR ALEFCGQHDD 670 680 690 700 710 720 DSVVNAGVLA NSLAQSFDNM PYLVSSTTCC LNALTNNNGF YYCSGDDFSA DTVSVATSVA GEDENWSY

References

[1]	"Expression of arginine decarboxylase is induced during early fruit development and in young tissues of Pisum sativum (L.)." Perez-Amador M.A., Carbonell J., Granell A. Plant Mol. Biol. 28:997-1009(1995) [PubMed: 7548836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z37540 mRNA. Translation: CAA85773.1.
PIR	S59553.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.1.19. 287.
Family and domain databases
InterPro	IPR002985. Arg_decrbxlase. IPR000183. De-COase2. [Graphical view]
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. speA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPE1_PEA

Accession

Primary (citable) accession number: Q43075

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)