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Reviewed, UniProtKB/Swiss-Prot Q43058 (HEM2_PHYPA)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Delta-aminolevulinic acid dehydratase, chloroplastic
      Short name=ALADH
    EC=4.2.1.24
Alternative name(s):
    Porphobilinogen synthase
Gene names
Name: HEMB
Synonyms: ALAD
OrganismPhyscomitrella patens (Moss)
Taxonomic identifier3218 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Bryophyta › Moss Superclass V › Bryopsida › Funariidae › Funariales › Funariaceae › Physcomitrella

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Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactor

Magnesium By similarity.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Subunit structure

Homooctamer By similarity.

Subcellular location

Plastid › chloroplast.

Sequence similarities

Belongs to the ALADH family.

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Ontologies

Keywords
   Biological processChlorophyll biosynthesis
Porphyrin biosynthesis
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandMagnesium
   Molecular functionLyase
Gene Ontology (GO)
   Biological processchlorophyll biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

porphobilinogen synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Chloroplast Potential
Chain? – 430Delta-aminolevulinic acid dehydratase, chloroplasticPRO_0000013318

Regions

Region220 – 23819Magnesium-binding By similarity

Sites

Active site3521 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q43058-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FD1A477A28DEA399

FASTA43046,140
        10         20         30         40         50         60 
MVGVMMAAAA TPGCRVSQAL TACSSHEGLR RVAPVFGPGV VSVSAPCKLP RKLNVQAVAE 

        70         80         90        100        110        120 
PIAKSSPRTI EECEANVVAG NAPAAPPVPA KPSAPEGTPA ISPLVMPARP RRNRRSPALR 

       130        140        150        160        170        180 
AAFQETTISP ANFILPLFVH EGEQNAPIGA MPGCQRLGWR HGLIDEVYKA RDVGVNSVVL 

       190        200        210        220        230        240 
FPKVPDALKS STGDEAYNPD GLVPRCIRLL KAIPDLVIYT DVALDPYSSD GHDGIVREDG 

       250        260        270        280        290        300 
LIMNDETVHQ LCKQAVAQAQ AGADVVSPSD MMDGRVGAIR KALDLAGHQD VSIIAYTAKY 

       310        320        330        340        350        360 
ASAFYGPSRE ALDSNPRFGD KKTYQMNPAN YREALIETRM DEAEGADILM VKPAMPYLDV 

       370        380        390        400        410        420 
IRLLRDNTAL PISAYQVSGE YSMIRAGCRG MLDEKKAVLE SLLSIRRAGA DVILTYFAIQ 

       430 
AAQWLCAERV

« Hide

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References

[1]Gwarek M.A.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

X89886 mRNA. Translation: CAA61978.1.
PIRS58169.

3D structure databases

HSSPHSSP built from PDB template 1GZG based on UniProtKB Q59643.
ModBaseSearch...

Enzyme and pathway databases

BRENDA4.2.1.24. 3698.

Family and domain databases

InterProIPR001731. 4pyrrol_synth_porphobiln_synth.
IPR013785. Aldolase_TIM.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR11458. AlaD_dehydratase. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PRINTSPR00144. DALDHYDRTASE.
ProDomPD002304. AlaD_dehydratase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHEM2_PHYPA
AccessionPrimary (citable) accession number: Q43058
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents