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Q43033 (TCMO_PETCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Trans-cinnamate 4-monooxygenase

EC=1.14.13.11
Alternative name(s):
Cinnamic acid 4-hydroxylase
Short name=C4H
Short name=CA4H
Cytochrome P450 73
Cytochrome P450C4H
Gene names
Name:CYP73A10
Synonyms:CYP73
OrganismPetroselinum crispum (Parsley) (Petroselinum hortense)
Taxonomic identifier4043 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsasteridscampanulidsApialesApiaceaeApioideaeapioid supercladeApieaePetroselinum

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Controls carbon flux to pigments essential for pollination or UV protection, to numerous pytoalexins synthesized by plants when challenged by pathogens, and to lignins.

Catalytic activity

Trans-cinnamate + NADPH + O2 = 4-hydroxycinnamate + NADP+ + H2O.

Cofactor

Heme group By similarity.

Pathway

Phenylpropanoid metabolism; trans-4-coumarate biosynthesis; trans-4-coumarate from trans-cinnamate: step 1/1.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Trans-cinnamate 4-monooxygenase
PRO_0000052249

Sites

Metal binding4481Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q43033 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 32F00EE959D69CCF

FASTA50658,048
        10         20         30         40         50         60 
MMDFVLLEKA LLGLFIATIV AITISKLRGK KLKLPPGPIP VPVFGNWLQV GDDLNQRNLV 

        70         80         90        100        110        120 
DYAKKFGDLF MLRMGQRNLV VVSSPELAKD VLHTQGVEFG SRTRNVVFDI FTGKGQDMVF 

       130        140        150        160        170        180 
TVYSEHWRKM RRIMTVPFFT NKVVQQYRFG WEDEAARVVE DVKANPEAAT NGIVLRNRLQ 

       190        200        210        220        230        240 
LLMYNNMYRI MFDRRFESVD DPLFLKLKAL NGERSRLAQS FEYHFGDFIP ILRPFLRGYL 

       250        260        270        280        290        300 
KLCQEIKDKR LKLFKDYFVD ERKKLESIKS VDNNSLKCAI DHIIEAQQKG EINEDNVLYI 

       310        320        330        340        350        360 
VENINVAAIE TTLWSIEWGI AELVNNPEIQ KKLRHELDTV LGAGVQICEP DVQKLPYLQA 

       370        380        390        400        410        420 
VIKETLRYRM AIPLLVPHMN LHDAKLAGYD IPAESKILVN AWWLANNPAH WNKPDEFRPE 

       430        440        450        460        470        480 
RFLEEESKVE ANGNDFKYIP FGVGRRSCPG IILALPILGI VIGRLVQNFE LLPPPGQSKI 

       490        500 
DTAEKGGQFS LQILKHSTIV CKPRSL 

« Hide

References

[1]"Modes of expression and common structural features of the complete phenylalanine ammonia-lyase gene family in parsley."
Logemann E., Parniske M., Hahlbrock K.
Proc. Natl. Acad. Sci. U.S.A. 92:5905-5909(1995) [PubMed: 7597051] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L38898 mRNA. Translation: AAC41660.1.
PIRT14907.

3D structure databases

ProteinModelPortalQ43033.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. Cytochrome_P450. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTCMO_PETCR
AccessionPrimary (citable) accession number: Q43033
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 28, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families