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Q42972 (MDHG_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase, glyoxysomal

EC=1.1.1.37
Gene names
Ordered Locus Names:Os12g0632700, LOC_Os12g43630
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subunit structure

Homodimer.

Subcellular location

Glyoxysome.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Sequence caution

The sequence ABA99939.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3636Glyoxysome Ref.3
Chain37 – 356320Malate dehydrogenase, glyoxysomal
PRO_0000018640

Regions

Nucleotide binding51 – 577NAD By similarity
Nucleotide binding160 – 1623NAD By similarity

Sites

Active site2201Proton acceptor By similarity
Binding site771NAD By similarity
Binding site1241Substrate By similarity
Binding site1301Substrate By similarity
Binding site1371NAD By similarity
Binding site1621Substrate By similarity
Binding site1961Substrate By similarity
Binding site2711NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q42972 [UniParc].

Last modified July 25, 2006. Version 3.
Checksum: D57BD93E93F381FB

FASTA35637,385
        10         20         30         40         50         60 
MEDAAAAARR MERLASHLRP PASQMEESPL LRGSNCRAKG AAPGFKVAIL GASGGIGQPL 

        70         80         90        100        110        120 
ALLMKMNPLV SVLHLYDVVN TPGVTADISH MNTGAVVRGF LGQPQLENAL TGMDLVIIPA 

       130        140        150        160        170        180 
GVPRKPGMTR DDLFNINAGI VRTLCEGIAK CCPNAIVNVI SNPVNSTVPI AAEVFKKAGT 

       190        200        210        220        230        240 
YDPKRLLGVT TLDVVRANTF VAEVLGLDPR DVNVPVIGGH AGVTILPLLS QVNPPCSFTS 

       250        260        270        280        290        300 
EEISYLTTRI QNGGTEVVEA KAGAGSATLS MAYAASKFAD ACLRGLRGDA GIVECSFVAS 

       310        320        330        340        350 
QVTELPFFAS KVRLGRCGIE EILSLGPLNE FERAGLEKAK KELAESIQKG VAFINK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a cDNA encoding Glyoxysomal malate dehydrogenase from rice (Oryza sativa L.)."
Kaminaka H., Morita S., Masumura T., Tanaka K.
Plant Gene Register PGR98-161
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Nipponbare.
[2]"The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
The rice chromosomes 11 and 12 sequencing consortia
BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"Proteomic analysis of rice leaf, stem and root tissues during growth course."
Nozu Y., Tsugita A., Kamijo K.
Proteomics 6:3665-3670(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 37-43, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D85763 mRNA. Translation: BAA12870.1.
DP000011 Genomic DNA. Translation: ABA99938.2.
DP000011 Genomic DNA. Translation: ABA99939.2. Sequence problems.
PIRT03272.
UniGeneOs.4155.

3D structure databases

ProteinModelPortalQ42972.
SMRQ42972. Positions 44-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING39947.LOC_Os12g43630.1.

Proteomic databases

PRIDEQ42972.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS12T0632700-01; OS12T0632700-01; OS12G0632700.

Organism-specific databases

GrameneQ42972.

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213792.
OMALGTHGVE.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDHG_ORYSJ
AccessionPrimary (citable) accession number: Q42972
Secondary accession number(s): Q2QLQ8, Q2QLQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations