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Protein

Malate dehydrogenase, glyoxysomal

Gene

Os12g0632700

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77NADBy similarity1
Binding sitei124SubstratePROSITE-ProRule annotation1
Binding sitei130SubstratePROSITE-ProRule annotation1
Binding sitei137NADBy similarity1
Binding sitei162SubstratePROSITE-ProRule annotation1
Binding sitei196SubstratePROSITE-ProRule annotation1
Active sitei220Proton acceptorBy similarity1
Binding sitei271NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 57NADBy similarity7
Nucleotide bindingi160 – 162NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

ReactomeiR-OSA-70263 Gluconeogenesis
R-OSA-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, glyoxysomal (EC:1.1.1.37)
Gene namesi
Ordered Locus Names:Os12g0632700, LOC_Os12g43630
ORF Names:OsJ_36976Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 36Glyoxysome1 PublicationAdd BLAST36
ChainiPRO_000001864037 – 356Malate dehydrogenase, glyoxysomalAdd BLAST320

Proteomic databases

PaxDbiQ42972
PRIDEiQ42972

Expressioni

Gene expression databases

ExpressionAtlasiQ42972 differential
GenevisibleiQ42972 OS

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi39947.LOC_Os12g43630.1

Structurei

3D structure databases

ProteinModelPortaliQ42972
SMRiQ42972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1494 Eukaryota
COG0039 LUCA
HOGENOMiHOG000213792
InParanoidiQ42972
KOiK00026
OMAiNDYERES
OrthoDBiEOG09360DTC

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDAAAAARR MERLASHLRP PASQMEESPL LRGSNCRAKG AAPGFKVAIL
60 70 80 90 100
GASGGIGQPL ALLMKMNPLV SVLHLYDVVN TPGVTADISH MNTGAVVRGF
110 120 130 140 150
LGQPQLENAL TGMDLVIIPA GVPRKPGMTR DDLFNINAGI VRTLCEGIAK
160 170 180 190 200
CCPNAIVNVI SNPVNSTVPI AAEVFKKAGT YDPKRLLGVT TLDVVRANTF
210 220 230 240 250
VAEVLGLDPR DVNVPVIGGH AGVTILPLLS QVNPPCSFTS EEISYLTTRI
260 270 280 290 300
QNGGTEVVEA KAGAGSATLS MAYAASKFAD ACLRGLRGDA GIVECSFVAS
310 320 330 340 350
QVTELPFFAS KVRLGRCGIE EILSLGPLNE FERAGLEKAK KELAESIQKG

VAFINK
Length:356
Mass (Da):37,385
Last modified:July 25, 2006 - v3
Checksum:iD57BD93E93F381FB
GO

Sequence cautioni

The sequence ABA99939 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85763 mRNA Translation: BAA12870.1
DP000011 Genomic DNA Translation: ABA99938.2
DP000011 Genomic DNA Translation: ABA99939.2 Sequence problems.
AP008218 Genomic DNA No translation available.
AP014968 Genomic DNA Translation: BAT18226.1
CM000149 Genomic DNA Translation: EEE53658.1
AK061793 mRNA Translation: BAG88115.1
AK065955 mRNA Translation: BAG89751.1
PIRiT03272
RefSeqiXP_015620524.1, XM_015765038.1
UniGeneiOs.4155

Genome annotation databases

EnsemblPlantsiOs12t0632700-01; Os12t0632700-01; Os12g0632700
GeneIDi4352871
GrameneiOs12t0632700-01; Os12t0632700-01; Os12g0632700
KEGGiosa:4352871

Similar proteinsi

Entry informationi

Entry nameiMDHG_ORYSJ
AccessioniPrimary (citable) accession number: Q42972
Secondary accession number(s): B7E6W8, Q2QLQ8, Q2QLQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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