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Protein

Malate dehydrogenase, glyoxysomal

Gene

Os12g0632700

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77NADBy similarity1
Binding sitei124SubstratePROSITE-ProRule annotation1
Binding sitei130SubstratePROSITE-ProRule annotation1
Binding sitei137NADBy similarity1
Binding sitei162SubstratePROSITE-ProRule annotation1
Binding sitei196SubstratePROSITE-ProRule annotation1
Active sitei220Proton acceptorBy similarity1
Binding sitei271NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 57NADBy similarity7
Nucleotide bindingi160 – 162NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

ReactomeiR-OSA-70263. Gluconeogenesis.
R-OSA-71403. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, glyoxysomal (EC:1.1.1.37)
Gene namesi
Ordered Locus Names:Os12g0632700, LOC_Os12g43630
ORF Names:OsJ_36976Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 36Glyoxysome1 PublicationAdd BLAST36
ChainiPRO_000001864037 – 356Malate dehydrogenase, glyoxysomalAdd BLAST320

Proteomic databases

PaxDbiQ42972.
PRIDEiQ42972.

Expressioni

Gene expression databases

GenevisibleiQ42972. OS.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi39947.LOC_Os12g43630.1.

Structurei

3D structure databases

ProteinModelPortaliQ42972.
SMRiQ42972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1494. Eukaryota.
COG0039. LUCA.
HOGENOMiHOG000213792.
InParanoidiQ42972.
KOiK00026.
OMAiCAYVASH.
OrthoDBiEOG09360DTC.

Family and domain databases

InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDAAAAARR MERLASHLRP PASQMEESPL LRGSNCRAKG AAPGFKVAIL
60 70 80 90 100
GASGGIGQPL ALLMKMNPLV SVLHLYDVVN TPGVTADISH MNTGAVVRGF
110 120 130 140 150
LGQPQLENAL TGMDLVIIPA GVPRKPGMTR DDLFNINAGI VRTLCEGIAK
160 170 180 190 200
CCPNAIVNVI SNPVNSTVPI AAEVFKKAGT YDPKRLLGVT TLDVVRANTF
210 220 230 240 250
VAEVLGLDPR DVNVPVIGGH AGVTILPLLS QVNPPCSFTS EEISYLTTRI
260 270 280 290 300
QNGGTEVVEA KAGAGSATLS MAYAASKFAD ACLRGLRGDA GIVECSFVAS
310 320 330 340 350
QVTELPFFAS KVRLGRCGIE EILSLGPLNE FERAGLEKAK KELAESIQKG

VAFINK
Length:356
Mass (Da):37,385
Last modified:July 25, 2006 - v3
Checksum:iD57BD93E93F381FB
GO

Sequence cautioni

The sequence ABA99939 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85763 mRNA. Translation: BAA12870.1.
DP000011 Genomic DNA. Translation: ABA99938.2.
DP000011 Genomic DNA. Translation: ABA99939.2. Sequence problems.
AP008218 Genomic DNA. No translation available.
AP014968 Genomic DNA. Translation: BAT18226.1.
CM000149 Genomic DNA. Translation: EEE53658.1.
AK061793 mRNA. Translation: BAG88115.1.
AK065955 mRNA. Translation: BAG89751.1.
PIRiT03272.
RefSeqiXP_015620524.1. XM_015765038.1.
UniGeneiOs.4155.

Genome annotation databases

EnsemblPlantsiOS12T0632700-01; OS12T0632700-01; OS12G0632700.
GeneIDi4352871.
GrameneiOS12T0632700-01; OS12T0632700-01; OS12G0632700.
KEGGiosa:4352871.

Similar proteinsi

Entry informationi

Entry nameiMDHG_ORYSJ
AccessioniPrimary (citable) accession number: Q42972
Secondary accession number(s): B7E6W8, Q2QLQ8, Q2QLQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 25, 2006
Last modified: August 30, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families