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Q42942 (UMPS_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine 5'-monophosphate synthase

Short name=UMP synthase

Including the following 2 domains:

  1. Orotate phosphoribosyltransferase
    Short name=OPRTase
    EC=2.4.2.10
  2. Orotidine 5'-phosphate decarboxylase
    EC=4.1.1.23
    Alternative name(s):
    OMPdecase
Gene names
Name:PYR5-6
OrganismNicotiana tabacum (Common tobacco)
Taxonomic identifier4097 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length461 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01208

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP-Rule MF_01208

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

In the C-terminal section; belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 461›461Uridine 5'-monophosphate synthase HAMAP-Rule MF_01208
PRO_0000139654

Sites

Active site2911 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q42942 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: AA96479701957CD1

FASTA46149,761
        10         20         30         40         50         60 
DISAVKFGEF KLKSGISSPI YIDLRLIVSY PSILRQISQT LVGSLPSSTK YDVVCGVPYT 

        70         80         90        100        110        120 
ALPIATCIST AHDVPMLMRR KEVKDYGTAK AIEGAFKPGQ ACLIVEDLVT SGASVLETAA 

       130        140        150        160        170        180 
PLRAAGLTVT DAVVMIDREQ GGRENLAENG ITLHSMVKLT EMVKILKEKG RVSEETEKMV 

       190        200        210        220        230        240 
KKFLEENRKV AVPVKETKVS LRLPYQERAK IAKNPTGKKL FEIMVQKETN LCLSADVATA 

       250        260        270        280        290        300 
AELLDIADKV GPEICMLKTH VDILPDFTPD FGSKLRSIAD KHNFLIFEDR KFADIGNTVT 

       310        320        330        340        350        360 
MQYEGGIFRI LDWADITNAH IISGPGIVDG LKLKGLSRGR GLLLLAEMSS AGNLATGAYT 

       370        380        390        400        410        420 
AAAVKIAEDH SDFVIGFISV NPASWPNAPG NPSLIHATPG VQLVKGGDAL GQLYNTPSAV 

       430        440        450        460 
IADRGSDIII VGRGIIKAAN PIEAAREYRL QGWDAYLVNC K 

« Hide

References

[1]"Nucleotide sequence of a cDNA encoding UMP synthase from Nicotiana tabacum."
Maier T., Zhou L., Thornburg R.W.
Plant Gene Register PGR95-025
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. SR1.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22260 mRNA. Translation: AAC49115.1.
PIRT02058.

3D structure databases

ProteinModelPortalQ42942.
SMRQ42942. Positions 203-457.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ42942.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00119.
UPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPMF_01208. PyrE.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUMPS_TOBAC
AccessionPrimary (citable) accession number: Q42942
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways