SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q42919

- G6PD_MEDSA

UniProt

Q42919 - G6PD_MEDSA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform
Gene
N/A
Organism
Medicago sativa (Alfalfa)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711NADP By similarity
Binding sitei182 – 1821NADP; via carbonyl oxygen By similarity
Binding sitei182 – 1821Substrate By similarity
Binding sitei250 – 2501Substrate By similarity
Binding sitei269 – 2691Substrate By similarity
Active sitei274 – 2741Proton acceptor By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei365 – 3651Substrate By similarity
Binding sitei396 – 3961Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform (EC:1.1.1.49)
Short name:
G6PD
OrganismiMedicago sativa (Alfalfa)
Taxonomic identifieri3879 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoformUniRule annotation
PRO_0000068100Add
BLAST

Proteomic databases

PRIDEiQ42919.

Structurei

3D structure databases

ProteinModelPortaliQ42919.
SMRiQ42919. Positions 28-511.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 2165Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42919-1 [UniParc]FASTAAdd to Basket

« Hide

MGTNEWHVER RDSIGTESPV AREVLETGTL SIVVLGASGD LAKKKTFPAL    50
FHLYKQELLP PDEVHIFGYA RSKISDDELR NKLRSYLVPE KGASPKQLDD 100
VSKFLQLVKY VSGPYDSEDG FRLLDKEISE HEYLKNSKEG SSRRLFYLAL 150
PPSVYPSVCK MIKTCCMNKS DLGGWTRVVV EKPFGRDLES AEELSTQIGE 200
LFEEPQIYRI DHYLGKELVQ NMLVLRFANR FFLPLWNHNH IDNVQIVFRE 250
DFGTDGRGGY FDQYGIIRDI IPNHLLQVLC LIAMEKPVSL KPEHIRDEKV 300
KVLESVLPIR DDEVVLGQYE GYTDDPTVPD DSNTPTFATT ILRIHNERWE 350
GVPFIVKAGK ALNSRKAEIR VQFKDVPGDI FRSKKQGRNE FVIRLQPSEA 400
IYMKLTVKQP GLEMSAVQSE LDLSYGQRYQ GITIPEAYER LILDTIRGDQ 450
QHFVRRDELK ASWQIFTPLL HKIDRGELKP VPYNPGSRGP AEADELLEKA 500
GYVQTPGYIW IPPTL 515
Length:515
Mass (Da):58,923
Last modified:November 1, 1996 - v1
Checksum:i836C1B96F2709FC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18238 mRNA. Translation: AAB41552.1.
PIRiS57785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18238 mRNA. Translation: AAB41552.1 .
PIRi S57785.

3D structure databases

ProteinModelPortali Q42919.
SMRi Q42919. Positions 28-511.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q42919.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stress responses in alfalfa (Medicago sativa L.) XIX. Transcriptional activation of oxidative pentose phosphate pathway genes at the onset of the isoflavonoid phytoalexin response."
    Fahrendorf T., Ni W., Shorrosh B.S., Dixon R.A.
    Plant Mol. Biol. 28:885-900(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Apollo.

Entry informationi

Entry nameiG6PD_MEDSA
AccessioniPrimary (citable) accession number: Q42919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi