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Q42919

- G6PD_MEDSA

UniProt

Q42919 - G6PD_MEDSA

Protein

Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform

Gene
N/A
Organism
Medicago sativa (Alfalfa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei71 – 711NADPBy similarity
    Binding sitei182 – 1821NADP; via carbonyl oxygenBy similarity
    Binding sitei182 – 1821SubstrateBy similarity
    Binding sitei250 – 2501SubstrateBy similarity
    Binding sitei269 – 2691SubstrateBy similarity
    Active sitei274 – 2741Proton acceptorBy similarity
    Binding sitei360 – 3601SubstrateBy similarity
    Binding sitei365 – 3651SubstrateBy similarity
    Binding sitei396 – 3961SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 438NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform (EC:1.1.1.49)
    Short name:
    G6PD
    OrganismiMedicago sativa (Alfalfa)
    Taxonomic identifieri3879 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoformPRO_0000068100Add
    BLAST

    Proteomic databases

    PRIDEiQ42919.

    Structurei

    3D structure databases

    ProteinModelPortaliQ42919.
    SMRiQ42919. Positions 28-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni212 – 2165Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q42919-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTNEWHVER RDSIGTESPV AREVLETGTL SIVVLGASGD LAKKKTFPAL    50
    FHLYKQELLP PDEVHIFGYA RSKISDDELR NKLRSYLVPE KGASPKQLDD 100
    VSKFLQLVKY VSGPYDSEDG FRLLDKEISE HEYLKNSKEG SSRRLFYLAL 150
    PPSVYPSVCK MIKTCCMNKS DLGGWTRVVV EKPFGRDLES AEELSTQIGE 200
    LFEEPQIYRI DHYLGKELVQ NMLVLRFANR FFLPLWNHNH IDNVQIVFRE 250
    DFGTDGRGGY FDQYGIIRDI IPNHLLQVLC LIAMEKPVSL KPEHIRDEKV 300
    KVLESVLPIR DDEVVLGQYE GYTDDPTVPD DSNTPTFATT ILRIHNERWE 350
    GVPFIVKAGK ALNSRKAEIR VQFKDVPGDI FRSKKQGRNE FVIRLQPSEA 400
    IYMKLTVKQP GLEMSAVQSE LDLSYGQRYQ GITIPEAYER LILDTIRGDQ 450
    QHFVRRDELK ASWQIFTPLL HKIDRGELKP VPYNPGSRGP AEADELLEKA 500
    GYVQTPGYIW IPPTL 515
    Length:515
    Mass (Da):58,923
    Last modified:November 1, 1996 - v1
    Checksum:i836C1B96F2709FC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18238 mRNA. Translation: AAB41552.1.
    PIRiS57785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18238 mRNA. Translation: AAB41552.1 .
    PIRi S57785.

    3D structure databases

    ProteinModelPortali Q42919.
    SMRi Q42919. Positions 28-511.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q42919.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Stress responses in alfalfa (Medicago sativa L.) XIX. Transcriptional activation of oxidative pentose phosphate pathway genes at the onset of the isoflavonoid phytoalexin response."
      Fahrendorf T., Ni W., Shorrosh B.S., Dixon R.A.
      Plant Mol. Biol. 28:885-900(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Apollo.

    Entry informationi

    Entry nameiG6PD_MEDSA
    AccessioniPrimary (citable) accession number: Q42919
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3