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Q42899

- GLNA1_LOTJA

UniProt

Q42899 - GLNA1_LOTJA

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Protein

Glutamine synthetase cytosolic isozyme

Gene

GLN1

Organism
Lotus japonicus (Lotus corniculatus var. japonicus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase cytosolic isozyme (EC:6.3.1.2)
Alternative name(s):
GS1
Glutamate--ammonia ligase
Gene namesi
Name:GLN1
OrganismiLotus japonicus (Lotus corniculatus var. japonicus)
Taxonomic identifieri34305 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeLoteaeLotus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Glutamine synthetase cytosolic isozymePRO_0000153175Add
BLAST

Proteomic databases

ProMEXiQ42899.

Interactioni

Subunit structurei

Homooctamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ42899.
SMRiQ42899. Positions 4-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42899 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLLSDLINL NLSETTDKII AEYIWIGGSG LDMRSKARTL PGPVSDPSQL
60 70 80 90 100
PKWNYDGSST GQAPGEDSEV ILYPQAIFRD PFRRGSNILV ICDAYTPAGE
110 120 130 140 150
PIPTNKRHAA AKVFSHPDVV AEVPWYGIEQ EYTLLQKEVN WPVGWPIGGF
160 170 180 190 200
PGPQGPYYCG IGADKAFGRD IVDAHYKACL YAGVNISGIN GEVMPGQWEF
210 220 230 240 250
QVGPSVGISA GDEVWVARYI LERITEIAGV VLSFDPKPIK GDWNGAGAHT
260 270 280 290 300
NYSTKTMRED GGYEVIKKAI DKLGLRHKEH IAAYGEGNER RLTGRHETAD
310 320 330 340 350
INTFLWGVAN RGASIRVGRD TEKEGKGYFE DRRPASNMDP YVVTSMIADT

TILWKP
Length:356
Mass (Da):39,147
Last modified:December 1, 2000 - v2
Checksum:iF31F8696F645F731
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351S → T in CAA73366. (PubMed:9323367)Curated
Sequence conflicti337 – 3371N → Y in CAA63963. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94299 mRNA. Translation: CAA63963.1.
Y12859 Genomic DNA. Translation: CAA73366.1.
UniGeneiLja.3240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94299 mRNA. Translation: CAA63963.1 .
Y12859 Genomic DNA. Translation: CAA73366.1 .
UniGenei Lja.3240.

3D structure databases

ProteinModelPortali Q42899.
SMRi Q42899. Positions 4-355.
ModBasei Search...
MobiDBi Search...

Proteomic databases

ProMEXi Q42899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a subunit of the cytosolic glutamine synthetase from Lotus japonicus."
    Ruiz M.T., Prosser I.M., Clarkson D.T.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Root.
  2. "Organization and expression of genes in the genomic region surrounding the glutamine synthetase gene Gln1 from Lotus japonicus."
    Thykjaer T., Danielsen D., She Q., Stougaard J.
    Mol. Gen. Genet. 255:628-636(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGLNA1_LOTJA
AccessioniPrimary (citable) accession number: Q42899
Secondary accession number(s): O04880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3