Q42884 (AROC1_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase 1, chloroplastic
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase 1

Gene names

Name:

CS1

Organism

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

Taxonomic identifier

4081 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum › Lycopersicon

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the last common step of the biosynthesis of aromatic amino acids, produced via the shikimic acid pathway.
Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.
Cofactor	Reduced flavin.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.
Subunit structure	Homotetramer By similarity.
Subcellular location	Plastid › chloroplast.
Tissue specificity	Predominantly expressed in flowers and roots and, to a lesser extent, in stems, leaves, and cotyledons.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Molecular function	Lyase
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 54	54	Chloroplast Potential
	Chain	55 – 440	386	Chorismate synthase 1, chloroplastic		PRO_0000002296

Sequences

	Sequence		Length	Mass (Da)
	Q42884 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: A4AFE9F410E2EAFA	FASTA	440	47,722
	10 20 30 40 50 60 MASFVPTKQF VGASSSSDIG SSRLVSLQLP SKFSSSNFHL PSRPSQLKRL EIQAAGSTFG 70 80 90 100 110 120 NYFRVTTFGE SHGGGVGCII DGCPPRLPLS ESDMQVELDR RRPGQSRITT PRKETDTCKI 130 140 150 160 170 180 SSGTADGLTT GSPIKVEVPN TDQRGNDYSE MSLAYRPSHA DATYDFKYGV RSVQGGGRSS 190 200 210 220 230 240 ARETIGRVAA GAVAKKILKL YSGAEVLAYV SQVHQVVLPE DLIDHQNVTL EQIESNIVRC 250 260 270 280 290 300 PDPEYAEKMI AAIDAVRVRG DSVGGVVTCI VRNLPRGLGT PVFDKLEAEL AKACMSLPAT 310 320 330 340 350 360 KGFEFGSGFA GTFMTGSEHN DEFYMDEHGR IRTRTNRSGG IQGGISNGEV INMRIGFKPT 370 380 390 400 410 420 STISRKQQTV TRDKHETELI ARGRHDPCVV PRAVPMVEAM VALVLVDQLM AQYSQCMMFP 430 440 INPELQEPLQ SSPESAEVTL

References

[1]	"Differential expression of tomato (Lycopersicon esculentum L.) genes encoding shikimate pathway isoenzymes. II. Chorismate synthase." Goerlach J., Schmid J., Amrheim N. Plant Mol. Biol. 23:707-716(1993) [PubMed: 8251624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. UC82B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z21796 mRNA. Translation: CAA79859.1.
PIR	S40410.
RefSeq	NP_001234422.1. NM_001247493.1.
UniGene	Les.209.
3D structure databases
ProteinModelPortal	Q42884.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	544154.
Family and domain databases
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC1_SOLLC

Accession

Primary (citable) accession number: Q42884

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program