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Protein

Pyruvate kinase, cytosolic isozyme

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • K+By similarity

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase (100818193), Pyruvate kinase (100799747), Pyruvate kinase (100781158), Pyruvate kinase (GLYMA_02G071100), Pyruvate kinase (GLYMA_10G178900), Pyruvate kinase (100802271), Pyruvate kinase (100807864), Pyruvate kinase (100781158), Pyruvate kinase (100807864), Pyruvate kinase (GLYMA_02G071000), Pyruvate kinase (100797214), Pyruvate kinase (GLYMA_09G1263002), Pyruvate kinase (100799747), Pyruvate kinase (GLYMA_10G141600), Pyruvate kinase (100801466), Pyruvate kinase (100815822), Pyruvate kinase (100807864), Pyruvate kinase (100815822), Pyruvate kinase (100790371), Pyruvate kinase (100799747), Pyruvate kinase (100807615), Pyruvate kinase (100797214), Pyruvate kinase (100790331), Pyruvate kinase, cytosolic isozyme, Pyruvate kinase (GLYMA_12G072800), Pyruvate kinase (GLYMA_11G041900), Pyruvate kinase (100809327), Pyruvate kinase (GLYMA_08G226500), Pyruvate kinase (100780644), Pyruvate kinase (GLYMA_05G000700), Pyruvate kinase, Pyruvate kinase, Pyruvate kinase (100776984), Pyruvate kinase (GLYMA_13G061000), Pyruvate kinase (100776984), Pyruvate kinase (GLYMA_20G211200), Pyruvate kinase (GLYMA_20G024800), Pyruvate kinase (100807864), Pyruvate kinase (100037452), Pyruvate kinase (pk3)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51SubstrateBy similarity1
Metal bindingi53PotassiumBy similarity1
Metal bindingi55PotassiumBy similarity1
Metal bindingi85PotassiumBy similarity1
Metal bindingi86Potassium; via carbonyl oxygenBy similarity1
Sitei241Transition state stabilizerBy similarity1
Metal bindingi243MagnesiumSequence analysis1
Binding sitei266Substrate; via amide nitrogenBy similarity1
Metal bindingi267MagnesiumBy similarity1
Binding sitei267Substrate; via amide nitrogenBy similarity1
Binding sitei299SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase, cytosolic isozyme (EC:2.7.1.40)
Short name:
PK
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Chromosome 5

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001121251 – 511Pyruvate kinase, cytosolic isozymeAdd BLAST511

Proteomic databases

PRIDEiQ42806
ProMEXiQ42806

Expressioni

Gene expression databases

GenevisibleiQ42806 GM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi3847.GLYMA05G09310.1

Structurei

3D structure databases

ProteinModelPortaliQ42806
SMRiQ42806
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
InParanoidiQ42806
KOiK00873
OMAiFETHANT
OrthoDBiEOG093607JW

Family and domain databases

CDDicd00288 Pyruvate_Kinase, 1 hit
Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q42806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANIDIEGIL KQQQPYDGRV PKTKIVCTLG PASRSVEMTE KLLRAGMNVA
60 70 80 90 100
RFNFSHGTHD YHQETLNNLK TAMHNTGILC AVMLDTKGPE IRTGFLKDGK
110 120 130 140 150
PIQLKEGQEV TITTDYDIKG DPEMISMSYK KLPVHLKPGN TILCSDGTIT
160 170 180 190 200
LTVLSCDPDA GTVRCRCENT ATLGERKNVN LPGVVVDLPT LTEKDKEDIL
210 220 230 240 250
GWGVPNKIDM IALSFVRKGS DLVNVRKVLG PHAKNIQLMS KVENQEGVLN
260 270 280 290 300
FDEILRETDA FMVARGDLGM EIPVEKIFLA QKMMIYKCNL VGKPVVTATQ
310 320 330 340 350
MLESMIKSPR PTRAEATDVA NAVLDGTDCV MLSGESAAGA YPELAVKIMA
360 370 380 390 400
RICIEAESSL DYGAIFKEMI RSTPLPMSPL ESLASSAVRT ANKAKAKLIV
410 420 430 440 450
VLTRGGSTAK LVAKYRPAVP ILSVVVPVLS TDSFDWTCSD ETPARHSLIY
460 470 480 490 500
RGLIPILGEG SAKATDAEST EVILEAALKS ATERALCKPG DAVVALHRIG
510
AASVIKICIV K
Length:511
Mass (Da):55,302
Last modified:November 1, 1996 - v1
Checksum:iBF0C06DAC6FD95F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08632 mRNA Translation: AAA17000.1
PIRiT07787
RefSeqiNP_001237968.1, NM_001251039.1
UniGeneiGma.4073

Genome annotation databases

EnsemblPlantsiKRH56499; KRH56499; GLYMA_05G000700
KRH56500; KRH56500; GLYMA_05G000700
GeneIDi547791
GrameneiKRH56499; KRH56499; GLYMA_05G000700
KRH56500; KRH56500; GLYMA_05G000700
KEGGigmx:547791

Similar proteinsi

Entry informationi

Entry nameiKPYC_SOYBN
AccessioniPrimary (citable) accession number: Q42806
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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