ID   TCMO_SOYBN              Reviewed;         506 AA.
AC   Q42797;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-MAR-2009, entry version 49.
DE   RecName: Full=Trans-cinnamate 4-monooxygenase;
DE            EC=1.14.13.11;
DE   AltName: Full=Cinnamic acid 4-hydroxylase;
DE            Short=CA4H;
DE            Short=C4H;
DE   AltName: Full=P450C4H;
DE   AltName: Full=Cytochrome P450 73;
GN   Name=CYP73A11;
OS   Glycine max (Soybean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids I; Fabales; Fabaceae; Papilionoideae; Phaseoleae;
OC   Glycine.
OX   NCBI_TaxID=3847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Harosoy 63;
RX   MEDLINE=98311068; PubMed=9648734; DOI=10.1007/s004380050736;
RA   Schopfer C.R., Ebel J.;
RT   "Identification of elicitor-induced cytochrome P450s of soybean
RT   (Glycine max L.) using differential display of mRNA.";
RL   Mol. Gen. Genet. 258:315-322(1998).
CC   -!- FUNCTION: Controls carbon flux to pigments essential for
CC       pollination or UV protection, to numerous pytoalexins synthesized
CC       by plants when challenged by pathogens, and to lignins.
CC   -!- CATALYTIC ACTIVITY: Trans-cinnamate + NADPH + O(2) = 4-
CC       hydroxycinnamate + NADP(+) + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- PATHWAY: Phenylpropanoid metabolism; 4-coumaric acid biosynthesis;
CC       4-coumaric acid from trans-cinnamic acid: step 1/1.
CC   -!- INDUCTION: By fungal elicitor.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
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DR   EMBL; X92437; CAA63172.1; -; mRNA.
DR   BRENDA; 1.14.13.11; 299.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0016710; F:trans-cinnamate 4-monooxygenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017973; Cyt_P450_C.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Monooxygenase; NADP; Oxidoreductase.
FT   CHAIN         1    506       Trans-cinnamate 4-monooxygenase.
FT                                /FTId=PRO_0000052254.
FT   METAL       448    448       Iron (heme axial ligand) (By similarity).
SQ   SEQUENCE   506 AA;  58011 MW;  0BA3F890EEE4FE19 CRC64;
     MDLLLLEKTL IGLFLAAVVA IAVSTLRGRK FKLPPGPLPV PIFGNWLQVG DDLNHRNLTD
     LAKKFGDIFL LRMGQRNLVV VSSPELAKEV LHTQGVEFGS RTRNVVFDIF TGKGQDMVFT
     VYGEHWRKMR RIMTVPFFTN KVVQQYRHGW ESEAAAVVED VKKNPDAAVS GTVIRRRLQL
     MMYNNMYRIM FDRRFESEED PIFQRLRALN GERSRLAQSF EYNYGDFIPI LRPFLKGYLK
     ICKEVKETRL KLFKDYFVDE RKKLGSTKST NNNNELKCAI DHILDAQRKG EINEDNVLYI
     VENINVAAIE TTLWSIEWGI AELVNHPEIQ QKLRDEIDRV LGAGHQVTEP DIQKLPYLQA
     VVKETLRLRM AIPLLVPHMN LHDAKLGGYD IPAESKILVN AWWLANNPAH WKKPEEFRPE
     RFFEEESLVE ANGNDFRYLP FGVGRRSCPG IILALPILGI TLGRLVQNFE LLPPPGQSQI
     DTSEKGGQFS LHILKHSTIV AKPRSF
//