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Reviewed, UniProtKB/Swiss-Prot Q42698 (GGPPS_CATRO)

Last modified January 19, 2010. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Geranylgeranyl pyrophosphate synthetase, chloroplastic
      Short name=GGPP synthetase
      Short name=GGPS
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29
Gene names
Name: GGPS1
Synonyms: GGC1
OrganismCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Taxonomic identifier4058 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Gentianales › Apocynaceae › Rauvolfioideae › Vinceae › Catharanthus

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Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.

Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Subcellular location

Plastid › chloroplast.

Sequence similarities

Belongs to the FPP/GGPP synthetase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4040Chloroplast Potential
Chain41 – 357317Geranylgeranyl pyrophosphate synthetase, chloroplastic
PRO_0000016473

Sites

Metal binding1451Magnesium 1 By similarity
Metal binding1451Magnesium 2 By similarity
Metal binding1511Magnesium 1 By similarity
Metal binding1511Magnesium 2 By similarity
Metal binding2831Magnesium 3 By similarity
Binding site1061Isopentenyl diphosphate By similarity
Binding site1091Isopentenyl diphosphate By similarity
Binding site1381Isopentenyl diphosphate By similarity
Binding site1561Dimethylallyl diphosphate By similarity
Binding site1571Isopentenyl diphosphate By similarity
Binding site2421Dimethylallyl diphosphate By similarity
Binding site2431Dimethylallyl diphosphate By similarity
Binding site2801Dimethylallyl diphosphate By similarity
Binding site2971Dimethylallyl diphosphate By similarity
Binding site3071Dimethylallyl diphosphate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q42698-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 81C52FDEA1E06FA8

FASTA35738,787
        10         20         30         40         50         60 
MRSNLCHPLK NQLPISFFLS GTIRKPIFSC SRLSISAIIT KEQTQEESES KSKKEVAFSS 

        70         80         90        100        110        120 
SSSFDFKAYM IGKANSVNKA LEDAVLVREP LKIHESMRYS LLAGGKRVRP MLCIAACELF 

       130        140        150        160        170        180 
GGTESVAMPS ACAVEMIHTM SLMHDDLPCM DNDDLRRGKP TNHKVFGEDV AVLAGDALLA 

       190        200        210        220        230        240 
FAFEHIATAT KGVSSERIVR VVGELAKCIG SEGLVAGQVV DVCSEGIADV GLEHLEFIHI 

       250        260        270        280        290        300 
HKTAALLEGS VVLGAIVGGA NDEQISKLRK FARCIGLLFQ VVDDILDVTK SSQELGKTAG 

       310        320        330        340        350 
KDLVADKVTY PKLLGIDKSR EFAEKLNREA QEQLAEFDPE KAAPLIALAN YIAYRDN

« Hide

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References

[1]"Nucleotide sequence of a Catharanthus roseus geranylgeranyl pyrophosphate synthase gene."
Bantignies B., Liboz T., Ambid C.
Plant Gene Register PGR95-119
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. G. Don c20.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X92893 Genomic DNA. Translation: CAA63486.1.
PIRT09966.

3D structure databases

SMRQ42698. Positions 68-352.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.5.1.1. 20471.
2.5.1.10. 20471.
2.5.1.29. 20471.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
PROSITEPS00723. POLYPRENYL_SYNTHET_1. 1 hit.
PS00444. POLYPRENYL_SYNTHET_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGGPPS_CATRO
AccessionPrimary (citable) accession number: Q42698
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: January 19, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents