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Protein

Glutamine synthetase cytosolic isozyme

Gene

GLN1

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase cytosolic isozyme (EC:6.3.1.2)
Alternative name(s):
GS1
Glutamate--ammonia ligase
Gene namesi
Name:GLN1
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Glutamine synthetase cytosolic isozymePRO_0000153169Add
BLAST

Proteomic databases

PRIDEiQ42688.
ProMEXiQ42688.

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi3055.EDP07598.

Structurei

3D structure databases

ProteinModelPortaliQ42688.
SMRiQ42688. Positions 31-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
KOiK01915.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSVGVFA TDEKIGSLLD QSITRHFLST VTDQQGKICA EYVWIGGSMH
60 70 80 90 100
DVRSKSRTLS TIPTKPEDLP HWNYDGSSTG QAPGHDSEVY LIPRSIFKDP
110 120 130 140 150
FRGGDNILVM CDCYEPPKVN PDGTLAAPKP IPTNTRFACA EVMEKAKKEE
160 170 180 190 200
PWFGIEQEYT LLNAITKWPL GWPKGGYPAP QGPYYCSAGA GVAIGRDVAE
210 220 230 240 250
VHYRLCLAAG VNISGVNAEV LPSQWEYQVG PCEGITMGDH MWMSRYIMYR
260 270 280 290 300
VCEMFNVEVS FDPKPIPGDW NGSGGHTNYS TKATRTAPDG WKVIQEHCAK
310 320 330 340 350
LEARHAVHIA AYGEGNERRL TGKHETSSMS DFSWGVANRG CSIRVGRMVP
360 370 380
VEKSGYYEDR RPASNLDAYV VTRLIVETTI LL
Length:382
Mass (Da):42,146
Last modified:November 1, 1997 - v1
Checksum:iCC806E221EE461F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46207 mRNA. Translation: AAB01817.1.
PIRiT08088.
RefSeqiXP_001699902.1. XM_001699850.1.
UniGeneiCre.13251.

Genome annotation databases

GeneIDi5725229.
KEGGicre:CHLREDRAFT_133971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46207 mRNA. Translation: AAB01817.1.
PIRiT08088.
RefSeqiXP_001699902.1. XM_001699850.1.
UniGeneiCre.13251.

3D structure databases

ProteinModelPortaliQ42688.
SMRiQ42688. Positions 31-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3055.EDP07598.

Proteomic databases

PRIDEiQ42688.
ProMEXiQ42688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5725229.
KEGGicre:CHLREDRAFT_133971.

Phylogenomic databases

eggNOGiCOG0174.
KOiK01915.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of glutamine synthetase genes in Chlamydomonas reinhardtii."
    Chen Q., Silflow C.D.
    Plant Physiol. 112:987-996(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A55.

Entry informationi

Entry nameiGLNA1_CHLRE
AccessioniPrimary (citable) accession number: Q42688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Irreversibly inhibited by the herbicide L-phosphinothricin (PPT).

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.