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Protein

Malate dehydrogenase, mitochondrial

Gene
N/A
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951NADBy similarity
Binding sitei141 – 1411SubstratePROSITE-ProRule annotation
Binding sitei147 – 1471SubstratePROSITE-ProRule annotation
Binding sitei154 – 1541NADBy similarity
Binding sitei179 – 1791SubstratePROSITE-ProRule annotation
Binding sitei213 – 2131SubstratePROSITE-ProRule annotation
Active sitei237 – 2371Proton acceptorBy similarity
Binding sitei288 – 2881NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 757NADBy similarity
Nucleotide bindingi177 – 1793NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 373Malate dehydrogenase, mitochondrialPRO_0000018624
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiQ42686.
ProMEXiQ42686.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3055.EDO96543.

Structurei

3D structure databases

ProteinModelPortaliQ42686.
SMRiQ42686. Positions 62-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0039.
KOiK00026.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQSSIRAD SNCTLPNNPV CVLLPVDFIV AAMASSTSSA MAKWAAQAAR
60 70 80 90 100
GFAAAAPSSG KGRKVAVLGA AGGIGQPLSM LMKMNSQVSS LSLYDIAGTP
110 120 130 140 150
GVAADVSHIN TKAQVKGFDK DGLAEALRGC DLVIIPAGVP RKPGMTRDDL
160 170 180 190 200
FKINAGIVRD LVTAVGQHCP GAVLNIISNP VNSTVPIAAE QLKKMGVYDK
210 220 230 240 250
RKVMGVTTLD VVRAKTFYAE KNGLDVASVD VPVVGGHAGV TILPLFSQAT
260 270 280 290 300
PKATMSAEVL DALTKRTQDG GTEVVQAKAG KGSATLSMAY AAALFADSCL
310 320 330 340 350
RGLNGAPVVE CTYVESTVTD APYFASKVKL STEGVDKIHD LGPLSDYEKA
360 370
GLKAMMPELL ASIEKGVQFV KGA
Length:373
Mass (Da):38,510
Last modified:November 1, 1997 - v1
Checksum:i0FCFEBFC58FD19BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40212 Genomic DNA. Translation: AAA84971.1.
PIRiT08077.
RefSeqiXP_001703167.1. XM_001703115.1.
UniGeneiCre.14161.

Genome annotation databases

GeneIDi5728707.
KEGGicre:CHLREDRAFT_60444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40212 Genomic DNA. Translation: AAA84971.1.
PIRiT08077.
RefSeqiXP_001703167.1. XM_001703115.1.
UniGeneiCre.14161.

3D structure databases

ProteinModelPortaliQ42686.
SMRiQ42686. Positions 62-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3055.EDO96543.

Proteomic databases

PRIDEiQ42686.
ProMEXiQ42686.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5728707.
KEGGicre:CHLREDRAFT_60444.

Phylogenomic databases

eggNOGiCOG0039.
KOiK00026.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Krishnasamy S., Chang T.E., Makaroff C.A., Wang W.Y.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMDHM_CHLRE
AccessioniPrimary (citable) accession number: Q42686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.