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Q42686

- MDHM_CHLRE

UniProt

Q42686 - MDHM_CHLRE

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Protein

Malate dehydrogenase, mitochondrial

Gene
N/A
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951NADBy similarity
Binding sitei141 – 1411SubstratePROSITE-ProRule annotation
Binding sitei147 – 1471SubstratePROSITE-ProRule annotation
Binding sitei154 – 1541NADBy similarity
Binding sitei179 – 1791SubstratePROSITE-ProRule annotation
Binding sitei213 – 2131SubstratePROSITE-ProRule annotation
Active sitei237 – 2371Proton acceptorBy similarity
Binding sitei288 – 2881NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 757NADBy similarity
Nucleotide bindingi177 – 1793NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 373Malate dehydrogenase, mitochondrialPRO_0000018624
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiQ42686.
ProMEXiQ42686.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ42686.
SMRiQ42686. Positions 62-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0039.
KOiK00026.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42686-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLQSSIRAD SNCTLPNNPV CVLLPVDFIV AAMASSTSSA MAKWAAQAAR
60 70 80 90 100
GFAAAAPSSG KGRKVAVLGA AGGIGQPLSM LMKMNSQVSS LSLYDIAGTP
110 120 130 140 150
GVAADVSHIN TKAQVKGFDK DGLAEALRGC DLVIIPAGVP RKPGMTRDDL
160 170 180 190 200
FKINAGIVRD LVTAVGQHCP GAVLNIISNP VNSTVPIAAE QLKKMGVYDK
210 220 230 240 250
RKVMGVTTLD VVRAKTFYAE KNGLDVASVD VPVVGGHAGV TILPLFSQAT
260 270 280 290 300
PKATMSAEVL DALTKRTQDG GTEVVQAKAG KGSATLSMAY AAALFADSCL
310 320 330 340 350
RGLNGAPVVE CTYVESTVTD APYFASKVKL STEGVDKIHD LGPLSDYEKA
360 370
GLKAMMPELL ASIEKGVQFV KGA
Length:373
Mass (Da):38,510
Last modified:November 1, 1997 - v1
Checksum:i0FCFEBFC58FD19BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40212 Genomic DNA. Translation: AAA84971.1.
PIRiT08077.
RefSeqiXP_001703167.1. XM_001703115.1.
UniGeneiCre.14161.

Genome annotation databases

GeneIDi5728707.
KEGGicre:CHLREDRAFT_60444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40212 Genomic DNA. Translation: AAA84971.1 .
PIRi T08077.
RefSeqi XP_001703167.1. XM_001703115.1.
UniGenei Cre.14161.

3D structure databases

ProteinModelPortali Q42686.
SMRi Q42686. Positions 62-371.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q42686.
ProMEXi Q42686.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5728707.
KEGGi cre:CHLREDRAFT_60444.

Phylogenomic databases

eggNOGi COG0039.
KOi K00026.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Krishnasamy S., Chang T.E., Makaroff C.A., Wang W.Y.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMDHM_CHLRE
AccessioniPrimary (citable) accession number: Q42686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3