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Q42686

- MDHM_CHLRE

UniProt

Q42686 - MDHM_CHLRE

Protein

Malate dehydrogenase, mitochondrial

Gene
N/A
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei95 – 951NADBy similarity
    Binding sitei141 – 1411SubstratePROSITE-ProRule annotation
    Binding sitei147 – 1471SubstratePROSITE-ProRule annotation
    Binding sitei154 – 1541NADBy similarity
    Binding sitei179 – 1791SubstratePROSITE-ProRule annotation
    Binding sitei213 – 2131SubstratePROSITE-ProRule annotation
    Active sitei237 – 2371Proton acceptorBy similarity
    Binding sitei288 – 2881NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 757NADBy similarity
    Nucleotide bindingi177 – 1793NADBy similarity

    GO - Molecular functioni

    1. copper ion binding Source: EnsemblPlants/Gramene
    2. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. defense response to bacterium Source: EnsemblPlants/Gramene
    3. malate metabolic process Source: InterPro
    4. response to cadmium ion Source: EnsemblPlants/Gramene
    5. response to cold Source: EnsemblPlants/Gramene
    6. response to salt stress Source: EnsemblPlants/Gramene
    7. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
    OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
    Taxonomic identifieri3055 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: EnsemblPlants/Gramene
    2. cell wall Source: EnsemblPlants/Gramene
    3. chloroplast Source: EnsemblPlants/Gramene
    4. membrane Source: EnsemblPlants/Gramene
    5. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 373Malate dehydrogenase, mitochondrialPRO_0000018624
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PRIDEiQ42686.
    ProMEXiQ42686.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ42686.
    SMRiQ42686. Positions 62-371.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0039.
    KOiK00026.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q42686-1 [UniParc]FASTAAdd to Basket

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    MSLQSSIRAD SNCTLPNNPV CVLLPVDFIV AAMASSTSSA MAKWAAQAAR    50
    GFAAAAPSSG KGRKVAVLGA AGGIGQPLSM LMKMNSQVSS LSLYDIAGTP 100
    GVAADVSHIN TKAQVKGFDK DGLAEALRGC DLVIIPAGVP RKPGMTRDDL 150
    FKINAGIVRD LVTAVGQHCP GAVLNIISNP VNSTVPIAAE QLKKMGVYDK 200
    RKVMGVTTLD VVRAKTFYAE KNGLDVASVD VPVVGGHAGV TILPLFSQAT 250
    PKATMSAEVL DALTKRTQDG GTEVVQAKAG KGSATLSMAY AAALFADSCL 300
    RGLNGAPVVE CTYVESTVTD APYFASKVKL STEGVDKIHD LGPLSDYEKA 350
    GLKAMMPELL ASIEKGVQFV KGA 373
    Length:373
    Mass (Da):38,510
    Last modified:November 1, 1997 - v1
    Checksum:i0FCFEBFC58FD19BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40212 Genomic DNA. Translation: AAA84971.1.
    PIRiT08077.
    RefSeqiXP_001703167.1. XM_001703115.1.
    UniGeneiCre.14161.

    Genome annotation databases

    GeneIDi5728707.
    KEGGicre:CHLREDRAFT_60444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40212 Genomic DNA. Translation: AAA84971.1 .
    PIRi T08077.
    RefSeqi XP_001703167.1. XM_001703115.1.
    UniGenei Cre.14161.

    3D structure databases

    ProteinModelPortali Q42686.
    SMRi Q42686. Positions 62-371.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q42686.
    ProMEXi Q42686.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5728707.
    KEGGi cre:CHLREDRAFT_60444.

    Phylogenomic databases

    eggNOGi COG0039.
    KOi K00026.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Krishnasamy S., Chang T.E., Makaroff C.A., Wang W.Y.
      Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMDHM_CHLRE
    AccessioniPrimary (citable) accession number: Q42686
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3