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Q42686

- MDHM_CHLRE

UniProt

Q42686 - MDHM_CHLRE

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Protein
Malate dehydrogenase, mitochondrial
Gene
N/A
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951NAD By similarity
Binding sitei141 – 1411Substrate By similarity
Binding sitei147 – 1471Substrate By similarity
Binding sitei154 – 1541NAD By similarity
Binding sitei179 – 1791Substrate By similarity
Binding sitei213 – 2131Substrate By similarity
Active sitei237 – 2371Proton acceptor By similarity
Binding sitei288 – 2881NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 757NAD By similarity
Nucleotide bindingi177 – 1793NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC
  2. copper ion binding Source: EnsemblPlants/Gramene
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. defense response to bacterium Source: EnsemblPlants/Gramene
  3. malate metabolic process Source: InterPro
  4. response to cadmium ion Source: EnsemblPlants/Gramene
  5. response to cold Source: EnsemblPlants/Gramene
  6. response to salt stress Source: EnsemblPlants/Gramene
  7. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: EnsemblPlants/Gramene
  2. cell wall Source: EnsemblPlants/Gramene
  3. chloroplast Source: EnsemblPlants/Gramene
  4. membrane Source: EnsemblPlants/Gramene
  5. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 373Malate dehydrogenase, mitochondrialPRO_0000018624
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PRIDEiQ42686.
ProMEXiQ42686.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ42686.
SMRiQ42686. Positions 62-371.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0039.
KOiK00026.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42686-1 [UniParc]FASTAAdd to Basket

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MSLQSSIRAD SNCTLPNNPV CVLLPVDFIV AAMASSTSSA MAKWAAQAAR    50
GFAAAAPSSG KGRKVAVLGA AGGIGQPLSM LMKMNSQVSS LSLYDIAGTP 100
GVAADVSHIN TKAQVKGFDK DGLAEALRGC DLVIIPAGVP RKPGMTRDDL 150
FKINAGIVRD LVTAVGQHCP GAVLNIISNP VNSTVPIAAE QLKKMGVYDK 200
RKVMGVTTLD VVRAKTFYAE KNGLDVASVD VPVVGGHAGV TILPLFSQAT 250
PKATMSAEVL DALTKRTQDG GTEVVQAKAG KGSATLSMAY AAALFADSCL 300
RGLNGAPVVE CTYVESTVTD APYFASKVKL STEGVDKIHD LGPLSDYEKA 350
GLKAMMPELL ASIEKGVQFV KGA 373
Length:373
Mass (Da):38,510
Last modified:November 1, 1997 - v1
Checksum:i0FCFEBFC58FD19BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40212 Genomic DNA. Translation: AAA84971.1.
PIRiT08077.
RefSeqiXP_001703167.1. XM_001703115.1.
UniGeneiCre.14161.

Genome annotation databases

GeneIDi5728707.
KEGGicre:CHLREDRAFT_60444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40212 Genomic DNA. Translation: AAA84971.1 .
PIRi T08077.
RefSeqi XP_001703167.1. XM_001703115.1.
UniGenei Cre.14161.

3D structure databases

ProteinModelPortali Q42686.
SMRi Q42686. Positions 62-371.
ModBasei Search...

Proteomic databases

PRIDEi Q42686.
ProMEXi Q42686.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5728707.
KEGGi cre:CHLREDRAFT_60444.

Phylogenomic databases

eggNOGi COG0039.
KOi K00026.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Krishnasamy S., Chang T.E., Makaroff C.A., Wang W.Y.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMDHM_CHLRE
AccessioniPrimary (citable) accession number: Q42686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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