ID   CFI_CALCH               Reviewed;         237 AA.
AC   Q42663;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 42.
DE   RecName: Full=Chalcone--flavonone isomerase;
DE            Short=Chalcone isomerase;
DE            EC=5.5.1.6;
DE   Flags: Fragment;
GN   Name=CHI; Synonyms=CH;
OS   Callistephus chinensis (China aster).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Astereae;
OC   Callistephus.
OX   NCBI_TaxID=13379;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=L 01; TISSUE=Petal;
RA   Henkel J., Wassenegger M., Sommer H., Forkmann G.;
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the intramolecular cyclization of bicyclic
CC       chalcones into tricyclic (S)-flavanones. Responsible for the
CC       isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed
CC       chalcone) into naringenin (By similarity).
CC   -!- CATALYTIC ACTIVITY: A chalcone = a flavanone.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid
CC       biosynthesis.
CC   -!- MISCELLANEOUS: Part of the biosynthetic pathway for all classes of
CC       flavonoids, a large class of secondary plant metabolites, many of
CC       which are brightly colored.
CC   -!- SIMILARITY: Belongs to the chalcone isomerase family.
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DR   EMBL; Z67980; CAA91921.1; -; mRNA.
DR   HSSP; P28012; 1EYQ.
DR   BRENDA; 5.5.1.6; 275959.
DR   GO; GO:0045430; F:chalcone isomerase activity; IEA:EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016088; Chalcone_isomerase_3-sand.
DR   InterPro; IPR003466; Chalcone_isomerase_subgr.
DR   Gene3D; G3DSA:3.50.70.10; Chalcone; 1.
DR   Pfam; PF02431; Chalcone; 1.
PE   2: Evidence at transcript level;
KW   Flavonoid biosynthesis; Isomerase.
FT   CHAIN        <1    237       Chalcone--flavonone isomerase.
FT                                /FTId=PRO_0000166429.
FT   BINDING      50     50       Substrate (By similarity).
FT   BINDING     192    192       Substrate (By similarity).
FT   SITE        108    108       Important for catalytic activity (By
FT                                similarity).
FT   NON_TER       1      1
SQ   SEQUENCE   237 AA;  25489 MW;  ED7956AE7541A973 CRC64;
     EFPTPLTTGL QVESIVFPSS VKPPGSTNSL FLGGAGVRGM EIQGNFVKFT GIGVYLEDKA
     IPLLAAKRKG KTVAELLDSV EFFRDIVTGP FEKFTQVTMI LPLTGKQYSE KVSEMCVGVW
     KALGTYTDAD GTTIEKFLEV FKDENFLPGS SILFTTSPLG SLTISFSKDG TIPEAANVVL
     ENEKLAQAVI ESVIGKNGVS PATKQSLASR LSDLMKQFDE ESNGSVEVED LSKNSCK
//