Q42663 (CFI_CALCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chalcone--flavonone isomerase
Short name=Chalcone isomerase
EC=5.5.1.6

Gene names

Name:	CHI
Synonyms:	CH

Organism

Callistephus chinensis (China aster) (Callistemma chinense)

Taxonomic identifier

13379 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Astereae › Australasian lineages › Callistephus

Protein attributes

Sequence length	237 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin By similarity.
Catalytic activity	A chalcone = a flavanone.
Pathway	Secondary metabolite biosynthesis; flavonoid biosynthesis.
Miscellaneous	Part of the biosynthetic pathway for all classes of flavonoids, a large class of secondary plant metabolites, many of which are brightly colored.
Sequence similarities	Belongs to the chalcone isomerase family.

Ontologies

Keywords
Biological process	Flavonoid biosynthesis
Molecular function	Isomerase
Gene Ontology (GO)
Biological_process	flavonoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	chalcone isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 237	›237	Chalcone--flavonone isomerase		PRO_0000166429
Sites
	Binding site	50	1	Substrate By similarity
	Binding site	192	1	Substrate By similarity
	Site	108	1	Important for catalytic activity By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q42663 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: ED7956AE7541A973	FASTA	237	25,489
	10 20 30 40 50 60 EFPTPLTTGL QVESIVFPSS VKPPGSTNSL FLGGAGVRGM EIQGNFVKFT GIGVYLEDKA 70 80 90 100 110 120 IPLLAAKRKG KTVAELLDSV EFFRDIVTGP FEKFTQVTMI LPLTGKQYSE KVSEMCVGVW 130 140 150 160 170 180 KALGTYTDAD GTTIEKFLEV FKDENFLPGS SILFTTSPLG SLTISFSKDG TIPEAANVVL 190 200 210 220 230 ENEKLAQAVI ESVIGKNGVS PATKQSLASR LSDLMKQFDE ESNGSVEVED LSKNSCK

References

[1]	Henkel J., Wassenegger M., Sommer H., Forkmann G. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: L 01. Tissue: Petal.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z67980 mRNA. Translation: CAA91921.1.
3D structure databases
ProteinModelPortal	Q42663.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00154.
Family and domain databases
Gene3D	3.50.70.10. 1 hit.
InterPro	IPR016087. Chalcone_isomerase. IPR016088. Chalcone_isomerase_3-sand. [Graphical view]
Pfam	PF02431. Chalcone. 1 hit. [Graphical view]
SUPFAM	SSF54626. Chalcone. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CFI_CALCH

Accession

Primary (citable) accession number: Q42663

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	March 6, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program