ID   Q42645_BETVU            Unreviewed;       331 AA.
AC   Q42645;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=fructokinase {ECO:0000256|ARBA:ARBA00038887};
DE            EC=2.7.1.4 {ECO:0000256|ARBA:ARBA00038887};
OS   Beta vulgaris (Sugar beet).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Chenopodiaceae; Betoideae; Beta.
OX   NCBI_TaxID=161934 {ECO:0000313|EMBL:AAA80675.1};
RN   [1] {ECO:0000313|EMBL:AAA80675.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Taproot {ECO:0000313|EMBL:AAA80675.1};
RA   Chaubron F., Taylor M.A., Ross H.A., Ledoigt G., Davies H.V.;
RT   "Isolation and characterisation of a cDNA clone of fructokinase from sugar
RT   beet (Beta vulgaris L.).";
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in maintaining the flux of carbon
CC       towards starch formation. {ECO:0000256|ARBA:ARBA00037195}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00036647};
CC   -!- PATHWAY: Glycan biosynthesis; starch biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004727}.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000256|ARBA:ARBA00010688, ECO:0000256|RuleBase:RU003704}.
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DR   EMBL; U37838; AAA80675.1; -; mRNA.
DR   PIR; T14544; T14544.
DR   AlphaFoldDB; Q42645; -.
DR   SMR; Q42645; -.
DR   BRENDA; 2.7.1.4; 836.
DR   GO; GO:0008865; F:fructokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006000; P:fructose metabolic process; IEA:UniProt.
DR   CDD; cd01167; bac_FRK; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR002139; Ribo/fructo_kinase.
DR   InterPro; IPR029056; Ribokinase-like.
DR   PANTHER; PTHR43085:SF24; FRUCTOKINASE-4-RELATED; 1.
DR   PANTHER; PTHR43085; HEXOKINASE FAMILY MEMBER; 1.
DR   Pfam; PF00294; PfkB; 1.
DR   PRINTS; PR00990; RIBOKINASE.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   Kinase {ECO:0000256|RuleBase:RU003704, ECO:0000313|EMBL:AAA80675.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003704}.
FT   DOMAIN          12..318
FT                   /note="Carbohydrate kinase PfkB"
FT                   /evidence="ECO:0000259|Pfam:PF00294"
SQ   SEQUENCE   331 AA;  35446 MW;  7B55EA106CC27241 CRC64;
     MAELNNGGHS KELVVSFGEM LIDFVPTSSG VSLAEAPGFL KAPGGAPANV AIAVSRLGGN
     AAFVGKLGDD EFGHMLAGIL KKNGVSADGL SFDKGARTAL AFVTLKSDGE REFMFYRNPS
     ADMLLTPDEL NLDLIRSAKV FHYGSIRLIV EPCRSAHLKA MEEAKKAGAL LSYDPNLRLP
     LWPSAEEARE QIMSIWDKAE VIKVSDNELE FLTGNSTIDD ATAMSLWHPN LKLLLVTLGD
     QGCRYYTKNF KGSLDGFKVN AVDTTGAGDS FVGALLNKIV DDHSIIEDES RLKEVLKFAN
     ACGAITTTKK GAIPALPTVA DALELIKKNA S
//