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Q42598 (THRC_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine synthase

Short name=TS
EC=4.2.3.1
Gene names
Name:thrc
ORF Names:SPAC9E9.06c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Sequence similarities

Belongs to the threonine synthase family.

Caution

Was originally (Ref.1) thought to originate from A.thaliana.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Threonine synthase
PRO_0000185644

Amino acid modifications

Modified residue1171N6-(pyridoxal phosphate)lysine By similarity
Modified residue3191Phosphoserine Ref.4
Modified residue3211Phosphoserine Ref.4

Experimental info

Sequence conflict253 – 2542SV → PA in BAA13852. Ref.3
Sequence conflict4461C → W in BAA13852. Ref.3
Sequence conflict4561D → G in BAA13852. Ref.3
Sequence conflict4591V → G in BAA13852. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q42598 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1C61AEFBB5F961C4

FASTA51457,632
        10         20         30         40         50         60 
MSSQVSYLST RGGSSNFSFE EAVLKGLAND GGLFIPSEIP QLPSGWIEAW KDKSFPEIAF 

        70         80         90        100        110        120 
EVMSLYIPRS EISADELKKL VDRSYSTFRH PETTPLKSLK NGLNVLELFH GPTFAFKDVA 

       130        140        150        160        170        180 
LQFLGNLFEF FLTRKNGNKP EDERDHLTVV GATSGDTGSA AIYGLRGKKD VSVFILFPNG 

       190        200        210        220        230        240 
RVSPIQEAQM TTVTDPNVHC ITVNGVFDDC QDLVKQIFGD VEFNKKHHIG AVNSINWARI 

       250        260        270        280        290        300 
LSQITYYLYS YLSVYKQGKA DDVRFIVPTG NFGDILAGYY AKRMGLPTKQ LVIATNENDI 

       310        320        330        340        350        360 
LNRFFKTGRY EKADSTQVSP SGPISAKETY SPAMDILVSS NFERYLWYLA LATEAPNHTP 

       370        380        390        400        410        420 
AEASEILSRW MNEFKRDGTV TVRPEVLEAA RRDFVSERVS NDETIDAIKK IYESDHYIID 

       430        440        450        460        470        480 
PHTAVGVETG LRCLEKTKDQ DITYICLSTA HPAKFDKAVN LALSSYSDYN FNTQVLPIEF 

       490        500        510 
DGLLDEERTC IFSGKPNIDI LKQIIEVTLS REKA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of cDNA encoding threonine synthase from Schizosaccharomyces pombe by functional expression in Saccharomyces cerevisiae."
Aas S.F., Rognes S.E.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-514.
Strain: PR745.
[4]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319 AND SER-321, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46263 mRNA. Translation: CAA86405.1.
CU329670 Genomic DNA. Translation: CAB16415.1.
D89190 mRNA. Translation: BAA13852.1.
PIRT39213.
T42748.
RefSeqNP_594579.1. NM_001020008.2.

3D structure databases

ProteinModelPortalQ42598.
SMRQ42598. Positions 2-511.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279107. 1 interaction.
MINTMINT-4700437.
STRING4896.SPAC9E9.06c-1.

Proteomic databases

PaxDbQ42598.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC9E9.06c.1; SPAC9E9.06c.1:pep; SPAC9E9.06c.
GeneID2542653.
KEGGspo:SPAC9E9.06c.

Organism-specific databases

PomBaseSPAC9E9.06c.

Phylogenomic databases

eggNOGCOG0498.
HOGENOMHOG000230745.
KOK01733.
OMAEEIASWA.
OrthoDBEOG7N0CDH.
PhylomeDBQ42598.

Enzyme and pathway databases

UniPathwayUPA00050; UER00065.

Family and domain databases

InterProIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803702.
PROQ42598.

Entry information

Entry nameTHRC_SCHPO
AccessionPrimary (citable) accession number: Q42598
Secondary accession number(s): P78841
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways