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Q42598

- THRC_SCHPO

UniProt

Q42598 - THRC_SCHPO

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Protein

Threonine synthase

Gene
thrc, SPAC9E9.06c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: PomBase

GO - Biological processi

  1. threonine biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrc
ORF Names:SPAC9E9.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC9E9.06c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Threonine synthasePRO_0000185644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171N6-(pyridoxal phosphate)lysine By similarity
Modified residuei319 – 3191Phosphoserine1 Publication
Modified residuei321 – 3211Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ42598.
PaxDbiQ42598.

Interactioni

Protein-protein interaction databases

BioGridi279107. 1 interaction.
MINTiMINT-4700437.
STRINGi4896.SPAC9E9.06c-1.

Structurei

3D structure databases

ProteinModelPortaliQ42598.
SMRiQ42598. Positions 2-511.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000230745.
KOiK01733.
OMAiILLWLES.
OrthoDBiEOG7N0CDH.
PhylomeDBiQ42598.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42598-1 [UniParc]FASTAAdd to Basket

« Hide

MSSQVSYLST RGGSSNFSFE EAVLKGLAND GGLFIPSEIP QLPSGWIEAW    50
KDKSFPEIAF EVMSLYIPRS EISADELKKL VDRSYSTFRH PETTPLKSLK 100
NGLNVLELFH GPTFAFKDVA LQFLGNLFEF FLTRKNGNKP EDERDHLTVV 150
GATSGDTGSA AIYGLRGKKD VSVFILFPNG RVSPIQEAQM TTVTDPNVHC 200
ITVNGVFDDC QDLVKQIFGD VEFNKKHHIG AVNSINWARI LSQITYYLYS 250
YLSVYKQGKA DDVRFIVPTG NFGDILAGYY AKRMGLPTKQ LVIATNENDI 300
LNRFFKTGRY EKADSTQVSP SGPISAKETY SPAMDILVSS NFERYLWYLA 350
LATEAPNHTP AEASEILSRW MNEFKRDGTV TVRPEVLEAA RRDFVSERVS 400
NDETIDAIKK IYESDHYIID PHTAVGVETG LRCLEKTKDQ DITYICLSTA 450
HPAKFDKAVN LALSSYSDYN FNTQVLPIEF DGLLDEERTC IFSGKPNIDI 500
LKQIIEVTLS REKA 514
Length:514
Mass (Da):57,632
Last modified:November 1, 1996 - v1
Checksum:i1C61AEFBB5F961C4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti253 – 2542SV → PA in BAA13852. 1 Publication
Sequence conflicti446 – 4461C → W in BAA13852. 1 Publication
Sequence conflicti456 – 4561D → G in BAA13852. 1 Publication
Sequence conflicti459 – 4591V → G in BAA13852. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46263 mRNA. Translation: CAA86405.1.
CU329670 Genomic DNA. Translation: CAB16415.1.
D89190 mRNA. Translation: BAA13852.1.
PIRiT39213.
T42748.
RefSeqiNP_594579.1. NM_001020008.2.

Genome annotation databases

EnsemblFungiiSPAC9E9.06c.1; SPAC9E9.06c.1:pep; SPAC9E9.06c.
GeneIDi2542653.
KEGGispo:SPAC9E9.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46263 mRNA. Translation: CAA86405.1 .
CU329670 Genomic DNA. Translation: CAB16415.1 .
D89190 mRNA. Translation: BAA13852.1 .
PIRi T39213.
T42748.
RefSeqi NP_594579.1. NM_001020008.2.

3D structure databases

ProteinModelPortali Q42598.
SMRi Q42598. Positions 2-511.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279107. 1 interaction.
MINTi MINT-4700437.
STRINGi 4896.SPAC9E9.06c-1.

Proteomic databases

MaxQBi Q42598.
PaxDbi Q42598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC9E9.06c.1 ; SPAC9E9.06c.1:pep ; SPAC9E9.06c .
GeneIDi 2542653.
KEGGi spo:SPAC9E9.06c.

Organism-specific databases

PomBasei SPAC9E9.06c.

Phylogenomic databases

eggNOGi COG0498.
HOGENOMi HOG000230745.
KOi K01733.
OMAi ILLWLES.
OrthoDBi EOG7N0CDH.
PhylomeDBi Q42598.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .

Miscellaneous databases

NextBioi 20803702.
PROi Q42598.

Family and domain databases

Gene3Di 3.90.1380.10. 1 hit.
InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA encoding threonine synthase from Schizosaccharomyces pombe by functional expression in Saccharomyces cerevisiae."
    Aas S.F., Rognes S.E.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-514.
    Strain: PR745.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319 AND SER-321, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiTHRC_SCHPO
AccessioniPrimary (citable) accession number: Q42598
Secondary accession number(s): P78841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) thought to originate from A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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