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Q42598

- THRC_SCHPO

UniProt

Q42598 - THRC_SCHPO

Protein

Threonine synthase

Gene

thrc

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: PomBase

    GO - Biological processi

    1. threonine biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrc
    ORF Names:SPAC9E9.06c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC9E9.06c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Threonine synthasePRO_0000185644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171N6-(pyridoxal phosphate)lysineBy similarity
    Modified residuei319 – 3191Phosphoserine1 Publication
    Modified residuei321 – 3211Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ42598.
    PaxDbiQ42598.

    Interactioni

    Protein-protein interaction databases

    BioGridi279107. 1 interaction.
    MINTiMINT-4700437.
    STRINGi4896.SPAC9E9.06c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ42598.
    SMRiQ42598. Positions 2-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0498.
    HOGENOMiHOG000230745.
    KOiK01733.
    OMAiILLWLES.
    OrthoDBiEOG7N0CDH.
    PhylomeDBiQ42598.

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q42598-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSQVSYLST RGGSSNFSFE EAVLKGLAND GGLFIPSEIP QLPSGWIEAW    50
    KDKSFPEIAF EVMSLYIPRS EISADELKKL VDRSYSTFRH PETTPLKSLK 100
    NGLNVLELFH GPTFAFKDVA LQFLGNLFEF FLTRKNGNKP EDERDHLTVV 150
    GATSGDTGSA AIYGLRGKKD VSVFILFPNG RVSPIQEAQM TTVTDPNVHC 200
    ITVNGVFDDC QDLVKQIFGD VEFNKKHHIG AVNSINWARI LSQITYYLYS 250
    YLSVYKQGKA DDVRFIVPTG NFGDILAGYY AKRMGLPTKQ LVIATNENDI 300
    LNRFFKTGRY EKADSTQVSP SGPISAKETY SPAMDILVSS NFERYLWYLA 350
    LATEAPNHTP AEASEILSRW MNEFKRDGTV TVRPEVLEAA RRDFVSERVS 400
    NDETIDAIKK IYESDHYIID PHTAVGVETG LRCLEKTKDQ DITYICLSTA 450
    HPAKFDKAVN LALSSYSDYN FNTQVLPIEF DGLLDEERTC IFSGKPNIDI 500
    LKQIIEVTLS REKA 514
    Length:514
    Mass (Da):57,632
    Last modified:November 1, 1996 - v1
    Checksum:i1C61AEFBB5F961C4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti253 – 2542SV → PA in BAA13852. (PubMed:9501991)Curated
    Sequence conflicti446 – 4461C → W in BAA13852. (PubMed:9501991)Curated
    Sequence conflicti456 – 4561D → G in BAA13852. (PubMed:9501991)Curated
    Sequence conflicti459 – 4591V → G in BAA13852. (PubMed:9501991)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46263 mRNA. Translation: CAA86405.1.
    CU329670 Genomic DNA. Translation: CAB16415.1.
    D89190 mRNA. Translation: BAA13852.1.
    PIRiT39213.
    T42748.
    RefSeqiNP_594579.1. NM_001020008.2.

    Genome annotation databases

    EnsemblFungiiSPAC9E9.06c.1; SPAC9E9.06c.1:pep; SPAC9E9.06c.
    GeneIDi2542653.
    KEGGispo:SPAC9E9.06c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46263 mRNA. Translation: CAA86405.1 .
    CU329670 Genomic DNA. Translation: CAB16415.1 .
    D89190 mRNA. Translation: BAA13852.1 .
    PIRi T39213.
    T42748.
    RefSeqi NP_594579.1. NM_001020008.2.

    3D structure databases

    ProteinModelPortali Q42598.
    SMRi Q42598. Positions 2-511.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279107. 1 interaction.
    MINTi MINT-4700437.
    STRINGi 4896.SPAC9E9.06c-1.

    Proteomic databases

    MaxQBi Q42598.
    PaxDbi Q42598.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC9E9.06c.1 ; SPAC9E9.06c.1:pep ; SPAC9E9.06c .
    GeneIDi 2542653.
    KEGGi spo:SPAC9E9.06c.

    Organism-specific databases

    PomBasei SPAC9E9.06c.

    Phylogenomic databases

    eggNOGi COG0498.
    HOGENOMi HOG000230745.
    KOi K01733.
    OMAi ILLWLES.
    OrthoDBi EOG7N0CDH.
    PhylomeDBi Q42598.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .

    Miscellaneous databases

    NextBioi 20803702.
    PROi Q42598.

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA encoding threonine synthase from Schizosaccharomyces pombe by functional expression in Saccharomyces cerevisiae."
      Aas S.F., Rognes S.E.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-514.
      Strain: PR745.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319 AND SER-321, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiTHRC_SCHPO
    AccessioniPrimary (citable) accession number: Q42598
    Secondary accession number(s): P78841
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally (PubMed:11859360) thought to originate from A.thaliana.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3