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Protein

Thionin-2.2

Gene

THI2.2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.

GO - Biological processi

  • defense response Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Thionin-2.2
Cleaved into the following 2 chains:
Gene namesi
Name:THI2.2
Ordered Locus Names:At5g36910
ORF Names:MLF18.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G36910.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 7046Thionin-2.2PRO_0000034141Add
BLAST
Chaini71 – 13464Acidic proteinSequence analysisPRO_0000034142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 64By similarity
Disulfide bondi28 ↔ 56By similarity
Disulfide bondi40 ↔ 50By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ42597.

Expressioni

Tissue specificityi

Low basal expression in seedlings. Also detected in rosette leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ42597. baseline and differential.
GenevisibleiQ42597. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G36910.1.

Structurei

3D structure databases

ProteinModelPortaliQ42597.
SMRiQ42597. Positions 25-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JGG2. Eukaryota.
ENOG410YY3S. LUCA.
HOGENOMiHOG000241884.
InParanoidiQ42597.
OMAiRCKLTSG.
PhylomeDBiQ42597.

Family and domain databases

Gene3Di3.30.1350.10. 1 hit.
InterProiIPR001010. Thionin.
[Graphical view]
PfamiPF00321. Thionin. 1 hit.
[Graphical view]
SUPFAMiSSF57429. SSF57429. 1 hit.
PROSITEiPS00271. THIONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKTVISSL LIMSLVLAQI QVEAKICCPT KDDRSVYFVC MLSVSSQFYC
60 70 80 90 100
LLKSKCKNTS QTICPPGYTN DILENSGDAV NEYCKLGCAS SVCGALTTLQ
110 120 130
NFDTSKVLSE AVEQCTKACS SVCTGGSTAA VKSA
Length:134
Mass (Da):14,178
Last modified:March 1, 2004 - v2
Checksum:i5F8A160F22E97CF4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131M → I in AAM62681 (Ref. 4) Curated
Sequence conflicti104 – 1041T → A in AAC41679 (PubMed:8552715).Curated
Sequence conflicti104 – 1041T → A in AAM62681 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41245 mRNA. Translation: AAC41679.1.
AB016877 Genomic DNA. Translation: BAB11632.1.
CP002688 Genomic DNA. Translation: AED94125.1.
AY085455 mRNA. Translation: AAM62681.1.
RefSeqiNP_198507.1. NM_123049.2.
UniGeneiAt.9367.

Genome annotation databases

EnsemblPlantsiAT5G36910.1; AT5G36910.1; AT5G36910.
GeneIDi833659.
GrameneiAT5G36910.1; AT5G36910.1; AT5G36910.
KEGGiath:AT5G36910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41245 mRNA. Translation: AAC41679.1.
AB016877 Genomic DNA. Translation: BAB11632.1.
CP002688 Genomic DNA. Translation: AED94125.1.
AY085455 mRNA. Translation: AAM62681.1.
RefSeqiNP_198507.1. NM_123049.2.
UniGeneiAt.9367.

3D structure databases

ProteinModelPortaliQ42597.
SMRiQ42597. Positions 25-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G36910.1.

Proteomic databases

PaxDbiQ42597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G36910.1; AT5G36910.1; AT5G36910.
GeneIDi833659.
GrameneiAT5G36910.1; AT5G36910.1; AT5G36910.
KEGGiath:AT5G36910.

Organism-specific databases

TAIRiAT5G36910.

Phylogenomic databases

eggNOGiENOG410JGG2. Eukaryota.
ENOG410YY3S. LUCA.
HOGENOMiHOG000241884.
InParanoidiQ42597.
OMAiRCKLTSG.
PhylomeDBiQ42597.

Miscellaneous databases

PROiQ42597.

Gene expression databases

ExpressionAtlasiQ42597. baseline and differential.
GenevisibleiQ42597. AT.

Family and domain databases

Gene3Di3.30.1350.10. 1 hit.
InterProiIPR001010. Thionin.
[Graphical view]
PfamiPF00321. Thionin. 1 hit.
[Graphical view]
SUPFAMiSSF57429. SSF57429. 1 hit.
PROSITEiPS00271. THIONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An Arabidopsis thaliana thionin gene is inducible via a signal transduction pathway different from that for pathogenesis-related proteins."
    Epple P., Apel K., Bohlmann H.
    Plant Physiol. 109:813-820(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Landsberg erecta.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
    Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTHN22_ARATH
AccessioniPrimary (citable) accession number: Q42597
Secondary accession number(s): Q8LEF0, Q9FIW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: May 11, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.